Dvl3 - dishevelled segment polarity protein 3 Gene

Mus musculus

Also known as b2b2866Clo

Gene ID: 13544 | Gene type: protein coding

About Dvl3

Summary

Enables protein-macromolecule adaptor activity. Involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway via JNK cascade. Acts upstream of or within cochlea morphogenesis; outflow tract septum morphogenesis; and planar cell polarity pathway involved in neural tube closure. Located in cytoplasm. Part of Wnt signalosome. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Dvl3 Products(2)

mRNA	Protein	Name
NM_001347176.1	NP_001334105.1	segment polarity protein dishevelled homolog DVL-3 isoform 2
NM_007889.3	NP_031915.2	segment polarity protein dishevelled homolog DVL-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11274398	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	23109420	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IGI IGI: Inferred from genetic interaction	19008950	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	18093802	MGI
acts upstream of or within cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	19008950	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	19008950	MGI
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11274398	MGI
involved in non-canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23109420	MGI
acts upstream of or within outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19008950	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17005174	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16501258	MGI
is active in synapse	IDA IDA: Inferred from direct assay	16501258	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

segment polarity protein dishevelled homolog DVL-3

dishevelled 3, dsh homolog

Dvl3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dvl3	Q61062	Vangl1	Mus musculus	Q80Z96	Y2H	15456783
Intra	Dvl3	Q61062	Dvl2	Mus musculus	Q60838	CoIP	21092292

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04078	DVL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dvl3	NCBI	NCBI:1857

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