Vangl1 - VANGL planar cell polarity 1 Gene

Mus musculus

Also known as Lpp2; Stb2; Stbm; Kitenin

Gene ID: 229658 | Gene type: protein coding

About Vangl1

Summary

Acts upstream of or within pigmentation. Located in lateral plasma membrane. Is expressed in several structures, including central nervous system; cochlea; future brain; notochord; and skin. Used to study neural tube defect. Human ortholog(s) of this gene implicated in caudal regression syndrome and neural tube defect. Orthologous to human VANGL1 (VANGL planar cell polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Vangl1 Products(1)

mRNA	Protein	Name
NM_177545.5	NP_808213.2	vang-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15456783	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mucociliary clearance	IMP IMP: Inferred from mutant phenotype	33929515	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	25340873	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	22935613	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vang-like protein 1

KAI1 COOH-terminal interacting tetraspanin	loop-tail protein 2
strabismus	van Gogh-like protein 1
vang, van gogh-like 1	vang-like 1 (van gogh, Drosophila)

Vangl1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Vangl1	Q80Z96	Dvl1	Mus musculus	P51141	Y2H	15456783
Intra	Vangl1	Q80Z96	Dvl3	Mus musculus	Q61062	Pull Down	15456783
Intra	Vangl1	Q80Z96	Dvl2	Mus musculus	Q60838	Pull Down	15456783
Intra	Vangl1	Q80Z96	Dvl2	Mus musculus	Q60838	Anti Bait CoIP	15456783
Intra	Vangl1	Q80Z96	Dvl2	Mus musculus	Q60838	Y2H	15456783
Cross	Vangl1	Q80Z96	Dlg4	Rattus norvegicus	P31016	Pull Down	23567299

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15600	VANGL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vangl1	NCBI	NCBI:81839

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