Mapre1 - microtubule-associated protein, RP/EB family, member 1 Gene

Mus musculus

Also known as Eb1; BIM1p; D2Ertd459e; 5530600P05Rik

Gene ID: 13589 | Gene type: protein coding

About Mapre1

Summary

Enables microtubule plus-end binding activity. Involved in microtubule bundle formation and microtubule polymerization. Acts upstream of or within non-motile cilium assembly; positive regulation of microtubule plus-end binding activity; and protein localization to microtubule Cytoskeleton. Located in Golgi apparatus; cell projection membrane; and microtubule Cytoskeleton. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapre1 Products(1)

mRNA	Protein	Name
NM_007896.3	NP_031922.1	microtubule-associated protein RP/EB family member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	16148041	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16148041	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in microtubule bundle formation	IDA IDA: Inferred from direct assay	24706950	MGI
involved in microtubule polymerization	IDA IDA: Inferred from direct assay	24706950	MGI
acts upstream of or within non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	17600711	MGI
acts upstream of or within positive regulation of microtubule plus-end binding	IDA IDA: Inferred from direct assay	16148041	MGI
acts upstream of or within positive regulation of microtubule plus-end binding	IGI IGI: Inferred from genetic interaction	16148041	MGI
acts upstream of or within protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	17600711	MGI
acts upstream of or within protein localization to microtubule	IMP IMP: Inferred from mutant phenotype	16247022	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11290329	MGI
located in cell projection	IDA IDA: Inferred from direct assay	16525027	MGI
located in cell projection membrane	IDA IDA: Inferred from direct assay	16621792	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	17600711	MGI
located in microtubule	IDA IDA: Inferred from direct assay	18854161	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	11290329	MGI
located in microtubule plus-end	IDA IDA: Inferred from direct assay	17600711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-associated protein RP/EB family member 1

APC-binding protein EB1	adenomatosis polyposis coli binding protein Eb1
end-binding protein 1

Mapre1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mapre1	Q61166	DST	Homo sapiens	Q03001	Pull Down	22995871
Cross	Mapre1	Q61166	DST	Homo sapiens	Q03001	Anti Tag CoIP	26496610
Intra	Mapre1	Q61166	Map1b	Mus musculus	P14873	Anti Bait CoIP	23572079
Intra	Mapre1	Q61166	Map1b	Mus musculus	P14873	Confocal	23572079
Intra	Mapre1	Q61166	Map1b	Mus musculus	P14873	Pull Down	23572079

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08137	MAPRE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapre1	NCBI	NCBI:22919

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