MAPRE1 - microtubule associated protein RP/EB family member 1 Gene

Homo sapiens

Also known as EB1

Gene ID: 22919 | Gene type: protein coding

About MAPRE1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,819,777-32,850,405 (from NCBI)

This gene has 1 transcript (splice variant), 264 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 71.1), thyroid (RPKM 48.1) and 25 other tissues.

Summary

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal Cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

MAPRE1 Products(1)

mRNA	Protein	Name
NM_012325.3	NP_036457.1	microtubule-associated protein RP/EB family member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	15631994	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10226031	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	26323690	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	23001180	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IPI IPI: Inferred from physical interaction	36592928	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	26242911	GOA
involved in establishment of mitotic spindle orientation	IDA IDA: Inferred from direct assay	34608293	GOA
involved in negative regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	11943150	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	27225956	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	29162697	GOA
involved in protein localization to astral microtubule	IDA IDA: Inferred from direct assay	34608293	GOA
involved in protein localization to microtubule	IDA IDA: Inferred from direct assay	19632184	GOA
involved in protein localization to mitotic spindle	IMP IMP: Inferred from mutant phenotype	27225956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cortical microtubule cytoskeleton	IDA IDA: Inferred from direct assay	15631994	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	25490267	GOA
is active in microtubule	IDA IDA: Inferred from direct assay	23001180	GOA
located in microtubule	IDA IDA: Inferred from direct assay	10773885	GOA
located in mitotic spindle astral microtubule end	IDA IDA: Inferred from direct assay	23509069	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	27225956	GOA
is active in mitotic spindle pole	IDA IDA: Inferred from direct assay	34608293	GOA
colocalizes with spindle	IDA IDA: Inferred from direct assay	11943150	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPRE1 Protein Structure

EB1

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

microtubule-associated protein RP/EB family member 1

APC-binding protein EB1

MAPRE1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	TAP	27173435
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Anti Tag CoIP	33961781
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	32296183
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Lumier	29997244
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	SLC	27107012
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	BFG-2H	27107012
Intra	MAPRE1	Q15691	MAPRE2	Homo sapiens	Q15555	Anti Tag CoIP	28514442
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Y2H Array	25416956
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	27107012
Intra	MAPRE1	Q15691	MAPRE2	Homo sapiens	Q15555	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	BRET	29997244
Intra	MAPRE1	Q15691	MAPRE3	Homo sapiens	Q9UPY8	Lumier	32814053
Intra	MAPRE1	Q15691	SPDYE2	Homo sapiens	Q495Y8	Validated Y2H	25416956
Intra	MAPRE1	Q15691	SPDYE2	Homo sapiens	Q495Y8	Y2H Array	25416956
Intra	MAPRE1	Q15691	SPDYE2	Homo sapiens	Q495Y8	Y2H Prey Pooling	25416956
Intra	MAPRE1	Q15691	APC2	Homo sapiens	O95996	Pull Down	10644998
Intra	MAPRE1	Q15691	APC2	Homo sapiens	O95996	Y2H	10644998
Intra	MAPRE1	Q15691	PDE4DIP	Homo sapiens	Q5VU43	Validated Y2H	25416956
Intra	MAPRE1	Q15691	PDE4DIP	Homo sapiens	Q5VU43	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	MAPRE1	Q15691	PDE4DIP	Homo sapiens	Q5VU43	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	31515488
Intra	MAPRE1	Q15691	PDE4DIP	Homo sapiens	Q5VU43	Y2H Prey Pooling	25416956
Intra	MAPRE1	Q15691	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	MAPRE1	Q15691	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	ZNF653	Homo sapiens	Q96CK0	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	ZNF653	Homo sapiens	Q96CK0	Validated Y2H	32296183
Intra	MAPRE1	Q15691	ZNF653	Homo sapiens	Q96CK0	Y2H Array	32296183
Intra	MAPRE1	Q15691	KIF2C	Homo sapiens	Q99661	IF	19543227
Intra	MAPRE1	Q15691	KIF2C	Homo sapiens	Q99661	Pull Down	19543227
Intra	MAPRE1	Q15691	KIF2C	Homo sapiens	Q99661	TAP	27173435
Intra	MAPRE1	Q15691	KIF2C	Homo sapiens	Q99661	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	KIF2C	Homo sapiens	Q99661	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	MAPRE1	Q15691	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	MAPRE1	Q15691	CCSER1	Homo sapiens	Q9C0I3-2	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	CCSER1	Homo sapiens	Q9C0I3-2	Validated Y2H	32296183
Intra	MAPRE1	Q15691	CCSER1	Homo sapiens	Q9C0I3-2	Y2H Array	32296183
Intra	MAPRE1	Q15691	C20orf202	Homo sapiens	A1L168	Y2H Array	32296183
Intra	MAPRE1	Q15691	C20orf202	Homo sapiens	A1L168	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	TROAP	Homo sapiens	Q12815	MAPPIT	25416956
Intra	MAPRE1	Q15691	TROAP	Homo sapiens	Q12815	Y2H Array	32296183
Intra	MAPRE1	Q15691	TROAP	Homo sapiens	Q12815	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	CLIP1	Homo sapiens	P30622	TAP	27173435
Intra	MAPRE1	Q15691	CLIP1	Homo sapiens	P30622	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	DST	Homo sapiens	Q03001	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	DST	Homo sapiens	Q03001	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	DST	Homo sapiens	Q03001	Pull Down	19632184
Intra	MAPRE1	Q15691	DST	Homo sapiens	Q03001	Anti Tag CoIP	33961781
Intra	MAPRE1	Q15691	DST	Homo sapiens	Q03001	Anti Tag CoIP	28514442
Intra	MAPRE1	Q15691	DSP	Homo sapiens	P15924	Anti Bait CoIP	25225338
Intra	MAPRE1	Q15691	DSP	Homo sapiens	P15924	Reverse RRS	25225338
Intra	MAPRE1	Q15691	DSP	Homo sapiens	P15924	Pull Down	25225338
Intra	MAPRE1	Q15691	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	MAPRE1	Q15691	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	MAPRE1	Q15691	KNSTRN	Homo sapiens	Q9Y448	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	KNSTRN	Homo sapiens	Q9Y448	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	KNSTRN	Homo sapiens	Q9Y448	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	KNSTRN	Homo sapiens	Q9Y448	Validated Y2H	32296183
Intra	MAPRE1	Q15691	KNSTRN	Homo sapiens	Q9Y448	Y2H Array	32296183
Intra	MAPRE1	Q15691	STIM1	Homo sapiens	Q13586	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	AURKB	Homo sapiens	Q96GD4	Y2H	18477699
Intra	MAPRE1	Q15691	AURKB	Homo sapiens	Q96GD4	Pull Down	18477699
Intra	MAPRE1	Q15691	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	18477699
Intra	MAPRE1	Q15691	CLIP1	Homo sapiens	P30622-2	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	TERF1	Homo sapiens	P54274	Pull Down	11943150
Intra	MAPRE1	Q15691	POLE2	Homo sapiens	P56282	Y2H Prey Pooling	25416956
Intra	MAPRE1	Q15691	POLE2	Homo sapiens	P56282	Validated Y2H	25416956
Intra	MAPRE1	Q15691	PQBP1	Homo sapiens	O60828	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	PQBP1	Homo sapiens	O60828	Y2H Prey Pooling	25416956
Intra	MAPRE1	Q15691	PQBP1	Homo sapiens	O60828	Y2H Array	32296183
Intra	MAPRE1	Q15691	DCTN1	Homo sapiens	Q14203	GMS	24997520
Intra	MAPRE1	Q15691	DCTN1	Homo sapiens	Q14203	TAP	27173435
Intra	MAPRE1	Q15691	DCTN1	Homo sapiens	Q14203	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	DCTN1	Homo sapiens	Q14203	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	APC	Homo sapiens	P25054	Pull Down	19632184
Intra	MAPRE1	Q15691	APC	Homo sapiens	P25054	ITC	19632184
Intra	MAPRE1	Q15691	APC	Homo sapiens	P25054	Pull Down	11943150
Intra	MAPRE1	Q15691	APC	Homo sapiens	P25054	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	APC	Homo sapiens	P25054	NMR	19632184
Intra	MAPRE1	Q15691	APC	Homo sapiens	P25054	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	MAPRE1	Q15691	LMO2	Homo sapiens	P25791	Y2H Array	25416956
Intra	MAPRE1	Q15691	LMO2	Homo sapiens	P25791	MAPPIT	25416956
Intra	MAPRE1	Q15691	MAPRE2	Homo sapiens	Q15555	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	MAPRE2	Homo sapiens	Q15555	Y2H Array	32296183
Intra	MAPRE1	Q15691	MAPRE2	Homo sapiens	Q15555	Anti Tag CoIP	33961781
Intra	MAPRE1	Q15691	KLHL12	Homo sapiens	Q53G59	Validated Y2H	32296183
Intra	MAPRE1	Q15691	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	MAPRE1	Q15691	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	MTUS2	Homo sapiens	Q5JR59	Pull Down	19543227
Intra	MAPRE1	Q15691	MTUS2	Homo sapiens	Q5JR59	IF	19543227
Intra	MAPRE1	Q15691	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	MAPRE1	Q15691	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	GAS2L2	Homo sapiens	Q8NHY3	Validated Y2H	32296183
Intra	MAPRE1	Q15691	GAS2L2	Homo sapiens	Q8NHY3	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	GAS2L2	Homo sapiens	Q8NHY3	Y2H Array	32296183
Intra	MAPRE1	Q15691	CLASP2	Homo sapiens	O75122	Anti Tag CoIP	33961781
Intra	MAPRE1	Q15691	CLASP2	Homo sapiens	O75122	TAP	27173435
Intra	MAPRE1	Q15691	CLASP2	Homo sapiens	O75122	Anti Tag CoIP	26496610
Intra	MAPRE1	Q15691	CLASP2	Homo sapiens	O75122	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	MARCHF7	Homo sapiens	Q9H992	Y2H Prey Pooling	32296183
Intra	MAPRE1	Q15691	MARCHF7	Homo sapiens	Q9H992	Anti Tag CoIP	35271311
Intra	MAPRE1	Q15691	MARCHF7	Homo sapiens	Q9H992	Validated Y2H	32296183
Intra	MAPRE1	Q15691	MARCHF7	Homo sapiens	Q9H992	Y2H Array	32296183
Intra	MAPRE1	Q15691	CLIP1	Homo sapiens	P30622-1	GMS	24997520
Intra	MAPRE1	Q15691	CLIP1	Homo sapiens	P30622-1	ITC	17828277

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Adenomatous Polyposis

Adenomatous Polyposis Coli	Fap
Familial Polyposis Coli	Familial Multiple Polyposis Syndrome
Adenomatous Polyposis Of The Colon	Familial Intestinal Polyposis
Fpc	Familial Adenomatous Polyposis Of The Colon
Familial Multiple Polyposis	Familial Polyposis Of The Colon
Hereditary Polyposis Coli	Polyposis, Adenomatous Intestinal
Adenomatous Familial Polyposis	Adenomatous Familial Polyposis Syndrome
Myh-Associated Polyposis	Colorectal Adenomatous Polyposis
Adenomatous Polyposis, Familial	Mutyh-Associate Polyposis

Distal Hereditary Motor Neuronopathy Type 7

Dhmn7	Dhmnvpy
Distal Spinal Muscular Atrophy With Vocal Cord Paralysis

Neuropathy, Hereditary Sensory And Autonomic, Type Vi

Hereditary Sensory And Autonomic Neuropathy Type 6	HSAN6
Hsan Vi	Hereditary Sensory And Autonomic Neuropathy Type Vi
Familial Dysautonomia With Contractures	Neuropathy, Hereditary Sensory And Autonomic, 6
Hereditary Sensory Neuropathy Type Vi	Hsn Vi
Neuropathy, Sensory And Autonomic, Hereditary, Type Vi

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Theileriasis

Theileriosis

Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08137	MAPRE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAPRE1	MGD	MGI:891995
Bos taurus	MAPRE1	VGNC	VGNC:31232
Felis catus	MAPRE1	VGNC	VGNC:68179
Macaca mulatta	MAPRE1	VGNC	VGNC:107798
Rattus norvegicus	MAPRE1	RGD	RGD:621781

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