2. Gene
  3. MAPRE1 - microtubule associated protein RP/EB family member 1 Gene

MAPRE1 - microtubule associated protein RP/EB family member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EB1

Gene ID: 22919 | Gene type: protein coding

About MAPRE1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,819,777-32,850,405 (from NCBI)

This gene has 1 transcript (splice variant), 264 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 71.1), thyroid (RPKM 48.1) and 25 other tissues.

Summary

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal Cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

MAPRE1 Products(1)

mRNA Protein Name
NM_012325.3 NP_036457.1 microtubule-associated protein RP/EB family member 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
15631994 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10226031 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
26323690 GOA
Biological Process GO Annotation Evidence Reference Source
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
23001180 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IPI
IPI: Inferred from physical interaction
36592928 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
26242911 GOA
involved in establishment of mitotic spindle orientation IDA
IDA: Inferred from direct assay
34608293 GOA
involved in negative regulation of microtubule polymerization IDA
IDA: Inferred from direct assay
11943150 GOA
involved in positive regulation of microtubule polymerization IDA
IDA: Inferred from direct assay
27225956 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
29162697 GOA
involved in protein localization to astral microtubule IDA
IDA: Inferred from direct assay
34608293 GOA
involved in protein localization to microtubule IDA
IDA: Inferred from direct assay
19632184 GOA
involved in protein localization to mitotic spindle IMP
IMP: Inferred from mutant phenotype
27225956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in cortical microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15631994 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
25490267 GOA
is active in microtubule IDA
IDA: Inferred from direct assay
23001180 GOA
located in microtubule IDA
IDA: Inferred from direct assay
10773885 GOA
located in mitotic spindle astral microtubule end IDA
IDA: Inferred from direct assay
23509069 GOA
located in mitotic spindle microtubule IDA
IDA: Inferred from direct assay
27225956 GOA
is active in mitotic spindle pole IDA
IDA: Inferred from direct assay
34608293 GOA
colocalizes with spindle IDA
IDA: Inferred from direct assay
11943150 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPRE1 Protein Structure

CH

CH: Calponin homology (CH) domain (18 - 115)

EB1

EB1: EB1-like C-terminal motif (210 - 248)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

microtubule-associated protein RP/EB family member 1

APC-binding protein EB1

MAPRE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
TAP
27173435
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Anti Tag CoIP
33961781
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Lumier
29997244
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
SLC
27107012
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
BFG-2H
27107012
Intra
MAPRE1 Q15691 MAPRE2 Homo sapiens Q15555
Anti Tag CoIP
28514442
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Y2H Array
25416956
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
27107012
Intra
MAPRE1 Q15691 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
BRET
29997244
Intra
MAPRE1 Q15691 MAPRE3 Homo sapiens Q9UPY8
Lumier
32814053
Intra
MAPRE1 Q15691 SPDYE2 Homo sapiens Q495Y8
Validated Y2H
25416956
Intra
MAPRE1 Q15691 SPDYE2 Homo sapiens Q495Y8
Y2H Array
25416956
Intra
MAPRE1 Q15691 SPDYE2 Homo sapiens Q495Y8
Y2H Prey Pooling
25416956
Intra
MAPRE1 Q15691 APC2 Homo sapiens O95996
Pull Down
10644998
Intra
MAPRE1 Q15691 APC2 Homo sapiens O95996
Y2H
10644998
Intra
MAPRE1 Q15691 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra
MAPRE1 Q15691 PDE4DIP Homo sapiens Q5VU43
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 PDE4DIP Homo sapiens Q5VU43
Y2H Array
25416956
Intra
MAPRE1 Q15691 PDE4DIP Homo sapiens Q5VU43
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 PDE4DIP Homo sapiens Q5VU43
Y2H Array
31515488
Intra
MAPRE1 Q15691 PDE4DIP Homo sapiens Q5VU43
Y2H Prey Pooling
25416956
Intra
MAPRE1 Q15691 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
MAPRE1 Q15691 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 ZNF653 Homo sapiens Q96CK0
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 ZNF653 Homo sapiens Q96CK0
Validated Y2H
32296183
Intra
MAPRE1 Q15691 ZNF653 Homo sapiens Q96CK0
Y2H Array
32296183
Intra
MAPRE1 Q15691 KIF2C Homo sapiens Q99661
IF
19543227
Intra
MAPRE1 Q15691 KIF2C Homo sapiens Q99661
Pull Down
19543227
Intra
MAPRE1 Q15691 KIF2C Homo sapiens Q99661
TAP
27173435
Intra
MAPRE1 Q15691 KIF2C Homo sapiens Q99661
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 KIF2C Homo sapiens Q99661
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
MAPRE1 Q15691 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
MAPRE1 Q15691 CCSER1 Homo sapiens Q9C0I3-2
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 CCSER1 Homo sapiens Q9C0I3-2
Validated Y2H
32296183
Intra
MAPRE1 Q15691 CCSER1 Homo sapiens Q9C0I3-2
Y2H Array
32296183
Intra
MAPRE1 Q15691 C20orf202 Homo sapiens A1L168
Y2H Array
32296183
Intra
MAPRE1 Q15691 C20orf202 Homo sapiens A1L168
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 TROAP Homo sapiens Q12815
MAPPIT
25416956
Intra
MAPRE1 Q15691 TROAP Homo sapiens Q12815
Y2H Array
32296183
Intra
MAPRE1 Q15691 TROAP Homo sapiens Q12815
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 CLIP1 Homo sapiens P30622
TAP
27173435
Intra
MAPRE1 Q15691 CLIP1 Homo sapiens P30622
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 DST Homo sapiens Q03001
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 DST Homo sapiens Q03001
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 DST Homo sapiens Q03001
Pull Down
19632184
Intra
MAPRE1 Q15691 DST Homo sapiens Q03001
Anti Tag CoIP
33961781
Intra
MAPRE1 Q15691 DST Homo sapiens Q03001
Anti Tag CoIP
28514442
Intra
MAPRE1 Q15691 DSP Homo sapiens P15924
Anti Bait CoIP
25225338
Intra
MAPRE1 Q15691 DSP Homo sapiens P15924
Reverse RRS
25225338
Intra
MAPRE1 Q15691 DSP Homo sapiens P15924
Pull Down
25225338
Intra
MAPRE1 Q15691 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
MAPRE1 Q15691 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra
MAPRE1 Q15691 KNSTRN Homo sapiens Q9Y448
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 KNSTRN Homo sapiens Q9Y448
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 KNSTRN Homo sapiens Q9Y448
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 KNSTRN Homo sapiens Q9Y448
Validated Y2H
32296183
Intra
MAPRE1 Q15691 KNSTRN Homo sapiens Q9Y448
Y2H Array
32296183
Intra
MAPRE1 Q15691 STIM1 Homo sapiens Q13586
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 AURKB Homo sapiens Q96GD4
Y2H
18477699
Intra
MAPRE1 Q15691 AURKB Homo sapiens Q96GD4
Pull Down
18477699
Intra
MAPRE1 Q15691 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
18477699
Intra
MAPRE1 Q15691 CLIP1 Homo sapiens P30622-2
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 TERF1 Homo sapiens P54274
Pull Down
11943150
Intra
MAPRE1 Q15691 POLE2 Homo sapiens P56282
Y2H Prey Pooling
25416956
Intra
MAPRE1 Q15691 POLE2 Homo sapiens P56282
Validated Y2H
25416956
Intra
MAPRE1 Q15691 PQBP1 Homo sapiens O60828
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 PQBP1 Homo sapiens O60828
Y2H Prey Pooling
25416956
Intra
MAPRE1 Q15691 PQBP1 Homo sapiens O60828
Y2H Array
32296183
Intra
MAPRE1 Q15691 DCTN1 Homo sapiens Q14203
GMS
24997520
Intra
MAPRE1 Q15691 DCTN1 Homo sapiens Q14203
TAP
27173435
Intra
MAPRE1 Q15691 DCTN1 Homo sapiens Q14203
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 DCTN1 Homo sapiens Q14203
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 APC Homo sapiens P25054
Pull Down
19632184
Intra
MAPRE1 Q15691 APC Homo sapiens P25054
ITC
19632184
Intra
MAPRE1 Q15691 APC Homo sapiens P25054
Pull Down
11943150
Intra
MAPRE1 Q15691 APC Homo sapiens P25054
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 APC Homo sapiens P25054
NMR
19632184
Intra
MAPRE1 Q15691 APC Homo sapiens P25054
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
MAPRE1 Q15691 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
MAPRE1 Q15691 LMO2 Homo sapiens P25791
MAPPIT
25416956
Intra
MAPRE1 Q15691 MAPRE2 Homo sapiens Q15555
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 MAPRE2 Homo sapiens Q15555
Y2H Array
32296183
Intra
MAPRE1 Q15691 MAPRE2 Homo sapiens Q15555
Anti Tag CoIP
33961781
Intra
MAPRE1 Q15691 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
Intra
MAPRE1 Q15691 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra
MAPRE1 Q15691 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 MTUS2 Homo sapiens Q5JR59
Pull Down
19543227
Intra
MAPRE1 Q15691 MTUS2 Homo sapiens Q5JR59
IF
19543227
Intra
MAPRE1 Q15691 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
MAPRE1 Q15691 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 GAS2L2 Homo sapiens Q8NHY3
Validated Y2H
32296183
Intra
MAPRE1 Q15691 GAS2L2 Homo sapiens Q8NHY3
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 GAS2L2 Homo sapiens Q8NHY3
Y2H Array
32296183
Intra
MAPRE1 Q15691 CLASP2 Homo sapiens O75122
Anti Tag CoIP
33961781
Intra
MAPRE1 Q15691 CLASP2 Homo sapiens O75122
TAP
27173435
Intra
MAPRE1 Q15691 CLASP2 Homo sapiens O75122
Anti Tag CoIP
26496610
Intra
MAPRE1 Q15691 CLASP2 Homo sapiens O75122
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 MARCHF7 Homo sapiens Q9H992
Y2H Prey Pooling
32296183
Intra
MAPRE1 Q15691 MARCHF7 Homo sapiens Q9H992
Anti Tag CoIP
35271311
Intra
MAPRE1 Q15691 MARCHF7 Homo sapiens Q9H992
Validated Y2H
32296183
Intra
MAPRE1 Q15691 MARCHF7 Homo sapiens Q9H992
Y2H Array
32296183
Intra
MAPRE1 Q15691 CLIP1 Homo sapiens P30622-1
GMS
24997520
Intra
MAPRE1 Q15691 CLIP1 Homo sapiens P30622-1
ITC
17828277
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Familial Adenomatous Polyposis

Adenomatous Polyposis Coli

Fap

Familial Polyposis Coli

Familial Multiple Polyposis Syndrome

Adenomatous Polyposis Of The Colon

Familial Intestinal Polyposis

Fpc

Familial Adenomatous Polyposis Of The Colon

Familial Multiple Polyposis

Familial Polyposis Of The Colon

Hereditary Polyposis Coli

Polyposis, Adenomatous Intestinal

Adenomatous Familial Polyposis

Adenomatous Familial Polyposis Syndrome

Myh-Associated Polyposis

Colorectal Adenomatous Polyposis

Adenomatous Polyposis, Familial

Mutyh-Associate Polyposis
Distal Hereditary Motor Neuronopathy Type 7

Dhmn7

Dhmnvpy

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis
Neuropathy, Hereditary Sensory And Autonomic, Type Vi

Hereditary Sensory And Autonomic Neuropathy Type 6

HSAN6

Hsan Vi

Hereditary Sensory And Autonomic Neuropathy Type Vi

Familial Dysautonomia With Contractures

Neuropathy, Hereditary Sensory And Autonomic, 6

Hereditary Sensory Neuropathy Type Vi

Hsn Vi

Neuropathy, Sensory And Autonomic, Hereditary, Type Vi
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Theileriasis

Theileriosis

Infection By Theileria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08137 MAPRE1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAPRE1 MGD MGI:891995
Bos taurus MAPRE1 VGNC VGNC:31232
Felis catus MAPRE1 VGNC VGNC:68179
Macaca mulatta MAPRE1 VGNC VGNC:107798
Rattus norvegicus MAPRE1 RGD RGD:621781