CPN1 - carboxypeptidase N subunit 1 Gene

Homo sapiens

Also known as CPN; SCPN

Gene ID: 1369 | Gene type: protein coding

About CPN1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:100,042,193-100,081,869 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues, 7 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 18.6).

Summary

Carboxypeptidase N is a plasma metallo-protease that cleaves basic Amino acids from the C terminal of Peptides and proteins. The Enzyme is important in the regulation of Peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This Enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from Carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

CPN1 Products(1)

mRNA	Protein	Name
NM_001308.3	NP_001299.1	carboxypeptidase N catalytic chain precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPN1 Protein Structure

Peptidase_M14

CarboxypepD_reg

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

carboxypeptidase N catalytic chain

anaphylatoxin inactivator

CPN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CPN1	P15169	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	CPN1	P15169	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	CPN1	P15169	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	CPN1	P15169	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carboxypeptidase N Deficiency

Anaphylotoxin Inactivator Deficiency	Deficiency Of Carboxypeptidase B
CPND

Chronic Urticaria

Urticaria Chronic	Chronic Spontaneous Urticaria
Chronic Ordinary Urticaria

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Inclusion Conjunctivitis

Chlamydial Conjunctivitis	Inclusion Blennorrhoea
Paratrachoma	Adult Inclusion Conjunctivitis
Inclusion Blenorrhea	Conjunctivitis, Inclusion
Neonatal Chlamydial Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Chronic Conjunctivitis Due To Chlamydia Trachomatis	Inclusion Conjunctivitis Due To Chlamydia Trachomatis
Acute Follicular Conjunctivitis, Chlamydial	Adult Chlamydial Keratoconjunctivitis

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Granuloma Inguinale

Donovanosis	Pudendal Ulcer
Granuloma Inguinale Tropicum	Granuloma Pudendi Tropicum

Ornithosis

Psittacosis	Chlamydial Pneumonia
Chlamydia Psittaci Infection	Chlamydia Psittaci

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03101	CPN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CPN1	MGD	MGI:2135874
Rattus norvegicus	CPN1	RGD	RGD:70931
Canis familiaris	CPN1	VGNC	VGNC:39558
Macaca mulatta	CPN1	VGNC	VGNC:71462
Felis catus	CPN1	VGNC	VGNC:61127
Bos taurus	CPN1	VGNC	VGNC:27656
Others	CPN1	NCBI

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