2. Gene
  3. UPRT - uracil phosphoribosyltransferase homolog Gene

UPRT - uracil phosphoribosyltransferase homolog Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UPP; FUR1

Gene ID: 139596 | Gene type: protein coding

About UPRT

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:75,156,369-75,304,897 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 3.5), thyroid (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The Enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and Cancer. [provided by RefSeq, Nov 2009]

UPRT Products(3)

mRNA Protein Name
NM_001307944.1 NP_001294873.1 uracil phosphoribosyltransferase homolog isoform 2
NM_001363821.1 NP_001350750.1 uracil phosphoribosyltransferase homolog isoform 3
NM_145052.4 NP_659489.1 uracil phosphoribosyltransferase homolog isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPRT Protein Structure

UPRTase

UPRTase: Uracil phosphoribosyltransferase (116 - 294)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

uracil phosphoribosyltransferase homolog

RP11-311P8.3

UPRT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Validated Y2H
32296183
Intra
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Y2H Array
32296183
Intra
UPRT Q96BW1 COMMD1 Homo sapiens Q8N668
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 COMMD1 Homo sapiens Q8N668
Y2H Array
32296183
Intra
UPRT Q96BW1 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra
UPRT Q96BW1 KAT5 Homo sapiens Q92993
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 KAT5 Homo sapiens Q92993
Y2H Array
32296183
Intra
UPRT Q96BW1 ERH Homo sapiens P84090
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 ERH Homo sapiens P84090
Y2H Array
32296183
Intra
UPRT Q96BW1 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
UPRT Q96BW1 NPM3 Homo sapiens O75607
Y2H Prey Pooling
32296183
Intra
UPRT Q96BW1 NPM3 Homo sapiens O75607
Y2H Array
32296183
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Array
32296183
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Validated Y2H
25416956
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Array
31515488
Intra
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UPRT Proteins

Cat. No. Product Name Accession Purity
HY-P71417 UPRT Protein, Human (His) Q96BW1-1 (M1-D309) ≥95%

Related Diseases

Diseases Alias
Geotrichosis
Breast Fibrosarcoma

Fibrosarcoma Of The Breast
Congenital Toxoplasmosis

Toxoplasmosis, Congenital

Mother-To-Child Transmission Of Toxoplasmosis

Toxoplasma Embryofetopathy

Toxoplasma Embryopathy

Toxoplasmosis - Congen.

Toxoplasmosis Congenital
Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis
Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3

FHL3

Hplh3

Hlh3

Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Orotic Aciduria

Hereditary Orotic Aciduria

Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency

Uridine Monophosphate Synthase Deficiency

Umps Deficiency

Uridine Monophosphate Synthetase Deficiency

Orotic Aciduria I

Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency

Oprt And Odc Deficiency

Ump Synthase Deficiency

Orotic Aciduria Ii

Oroticaciduria 1

Orotic Aciduria Hereditary

Orotic Aciduria Type 1

Hereditary Orotic Aciduria Without Megaloblastic Anemia

Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency

Ump Synthtase Deficiency

Umps

Orotidylic Decarboxylase Deficiency

Orotic Aciduria 1

ORAC1

Aciduria, Orotic

Hereditary Orotic Aciduria, Type 1

Orotic Aciduria Nos

Orotaciduric Anaemia

Orotic Aciduria Anaemia

Orotic Aciduria Megaloblastic Anaemia
Cryptosporidiosis

Cryptosporidial Gastroenteritis

Intestinal Cryptosporidiosis

Infection By Cryptosporidium

Gastroenteritis Due To Cryptosporidium

Cryptosporidial Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15492 UPRT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UPRT VGNC VGNC:48158
Rattus norvegicus UPRT RGD RGD:1564806
Bos taurus UPRT VGNC VGNC:36690
Macaca mulatta UPRT VGNC VGNC:81601
Mus musculus UPRT MGD MGI:2685620
Felis catus UPRT VGNC VGNC:97679
Others UPRT NCBI