2. Gene
  3. COMMD1 - copper metabolism domain containing 1 Gene

COMMD1 - copper metabolism domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MURR1; C2orf5

Gene ID: 150684 | Gene type: protein coding

About COMMD1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,888,391-62,136,058 (from NCBI)

This gene has 8 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in heart (RPKM 5.7), testis (RPKM 5.6) and 25 other tissues.

Summary

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

COMMD1 Products(4)

mRNA Protein Name
NM_001321781.3 NP_001308710.1 COMM domain-containing protein 1 isoform 2
NM_001321782.3 NP_001308711.1 COMM domain-containing protein 1 isoform 2
NM_001371765.2 NP_001358694.1 COMM domain-containing protein 1 isoform 2
NM_152516.4 NP_689729.1 COMM domain-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables copper ion binding IDA
IDA: Inferred from direct assay
17309234 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
15799966 GOA
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
18940794 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
18940794 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
18940794 GOA
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
18940794 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
18940794 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12968035 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
15799966 GOA
enables sodium channel inhibitor activity IDA
IDA: Inferred from direct assay
14645214 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Golgi to plasma membrane transport IMP
IMP: Inferred from mutant phenotype
25355947 GOA
involved in copper ion homeostasis IDA
IDA: Inferred from direct assay
14685266 GOA
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16573520 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15799966 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
17183367 GOA
involved in negative regulation of protein localization to cell surface IDA
IDA: Inferred from direct assay
21741370 GOA
involved in negative regulation of sodium ion transmembrane transport IDA
IDA: Inferred from direct assay
14645214 GOA
involved in negative regulation of sodium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
20237237 GOA
involved in nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
23144634 GOA
involved in plasma membrane to endosome transport IDA
IDA: Inferred from direct assay
21741370 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
17183367 GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17183367 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17183367 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
14685266 GOA
located in early endosome IDA
IDA: Inferred from direct assay
25355947 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15799966 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
21741370 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD1 Protein Structure

COMM_domain

COMM_domain: COMM domain (14 - 185)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

COMM domain-containing protein 1

copper metabolism (Murr1) domain containing 1

COMMD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Anti Bait CoIP
25355947
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Pull Down
25355947
Intra
COMMD1 Q8N668 CCDC93 Homo sapiens Q567U6
Confocal
25355947
Intra
COMMD1 Q8N668 ATP7B Homo sapiens P35670
Pull Down
12968035
Intra
COMMD1 Q8N668 ATP7B Homo sapiens P35670
Confocal
17919502
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
TAP
23563313
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
Pull Down
15799966
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
TAP
15799966
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
GMS
37172566
Intra
COMMD1 Q8N668 COMMD4 Homo sapiens Q9H0A8
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Y2H Array
25416956
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Pull Down
15799966
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Y2H Array
32296183
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Validated Y2H
25416956
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
TAP
23563313
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Anti Bait CoIP
23563313
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
GMS
37172566
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Y2H Prey Pooling
25416956
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
TAP
15799966
Intra
COMMD1 Q8N668 COMMD6 Homo sapiens Q7Z4G1
Y2H Prey Pooling
32296183
Intra
COMMD1 Q8N668 CCDC22 Homo sapiens O60826
Anti Bait CoIP
23563313
Intra
COMMD1 Q8N668 COMMD2 Homo sapiens Q86X83
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 COMMD2 Homo sapiens Q86X83
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD2 Homo sapiens Q86X83
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 COMMD2 Homo sapiens Q86X83
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD2 Homo sapiens Q86X83
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD5 Homo sapiens Q9GZQ3
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD5 Homo sapiens Q9GZQ3
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 COMMD5 Homo sapiens Q9GZQ3
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 COMMD5 Homo sapiens Q9GZQ3
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD5 Homo sapiens Q9GZQ3
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD5 Homo sapiens Q9GZQ3
Pull Down
15799966
Intra
COMMD1 Q8N668 COMMD7 Homo sapiens Q86VX2
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD7 Homo sapiens Q86VX2
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD7 Homo sapiens Q86VX2
Pull Down
15799966
Intra
COMMD1 Q8N668 COMMD7 Homo sapiens Q86VX2
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 COMMD10 Homo sapiens Q9Y6G5
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD10 Homo sapiens Q9Y6G5
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD10 Homo sapiens Q9Y6G5
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 COMMD10 Homo sapiens Q9Y6G5
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD10 Homo sapiens Q9Y6G5
Pull Down
15799966
Intra
COMMD1 Q8N668 COMMD10 Homo sapiens Q9Y6G5
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 TCEAL8 Homo sapiens Q8IYN2
Y2H Prey Pooling
32296183
Intra
COMMD1 Q8N668 TCEAL8 Homo sapiens Q8IYN2
Y2H Array
32296183
Intra
COMMD1 Q8N668 SCNN1D Homo sapiens P51172
Pull Down
14645214
Intra
COMMD1 Q8N668 ELOC Homo sapiens Q15369
Pull Down
23563313
Intra
COMMD1 Q8N668 ELOC Homo sapiens Q15369
Pull Down
17183367
Intra
COMMD1 Q8N668 REL Homo sapiens Q04864
Anti Bait CoIP
15799966
Intra
COMMD1 Q8N668 REL Homo sapiens Q04864
Pull Down
15799966
Intra
COMMD1 Q8N668 NFKBIA Homo sapiens P25963
Anti Tag CoIP
14685242
Intra
COMMD1 Q8N668 RELB Homo sapiens Q01201
Pull Down
15799966
Intra
COMMD1 Q8N668 CUL2 Homo sapiens Q13617
Pull Down
23563313
Intra
COMMD1 Q8N668 CUL2 Homo sapiens Q13617
Pull Down
17183367
Intra
COMMD1 Q8N668 COMMD3 Homo sapiens Q9UBI1
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD3 Homo sapiens Q9UBI1
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD3 Homo sapiens Q9UBI1
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 COMMD3 Homo sapiens Q9UBI1
TAP
23563313
Intra
COMMD1 Q8N668 COMMD3 Homo sapiens Q9UBI1
TAP
15799966
Intra
COMMD1 Q8N668 COMMD3 Homo sapiens Q9UBI1
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
Anti Tag CoIP
37172566
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
Pull Down
15799966
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
Anti Tag CoIP
28514442
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
3D-EM
37172566
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
Anti Tag CoIP
33961781
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
GMS
37172566
Intra
COMMD1 Q8N668 COMMD8 Homo sapiens Q9NX08
Anti Tag CoIP
35271311
Intra
COMMD1 Q8N668 RELA Homo sapiens Q04206
Anti Bait CoIP
15799966
Intra
COMMD1 Q8N668 RELA Homo sapiens Q04206
Pull Down
15799966
Intra
COMMD1 Q8N668 UPRT Homo sapiens Q96BW1
Validated Y2H
32296183
Intra
COMMD1 Q8N668 SOCS1 Homo sapiens O15524
Pull Down
17183367
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wilson Disease

Hepatolenticular Degeneration

WD

Wilson'S Disease

WND

Westphal-Strumpell Syndrome

Copper Storage Disease

Cerebral Pseudosclerosis

Westphal Pseudosclerosis

Hepatolenticular Degeneration Syndrome

Copper Retention

Hepatocerebral Degeneration

Kinnier-Wilson Disease

Neurohepatic Degeneration

Progressive Hepatolenticular Degeneration

Lenticular Degenerative Disease

Wilson'S Syndrome

Lenticular Syndrome
Nephrotic Syndrome, Type 20

NPHS20

Nephrotic Syndrome Type 20

Nephrotic Syndrome 20
Peroxisome Biogenesis Disorder 11a

PBD11A

Peroxisome Biogenesis Disorder Complementation Group 13

PBD-CG13

Cg13

Pbd-Cgh

Peroxisome Biogenesis Disorder Complementation Group H

Peroxisome Biogenesis Disorder, Type 11a

Peroxisome Biogenesis Disorder, Complementation Group 13
Retinitis Pigmentosa 28

RP28

Retinitis Pigmentosa, Type 28
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Menkes Disease

Copper Transport Disease

Menkes Syndrome

MNK

Kinky Hair Disease

Steely Hair Disease

Menkes Kinky-Hair Syndrome

Mk

Steely Hair Syndrome

Menkea Syndrome

Md

Menkes Kinky Hair Syndrome

Hypocupremia, Congenital

Kinky Hair Syndrome

X-Linked Copper Deficiency

Menkes Kinky Hair Disease
Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03009 COMMD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COMMD1 RGD RGD:1311771
Bos taurus COMMD1 VGNC VGNC:27581
Canis familiaris COMMD1 VGNC VGNC:39491
Felis catus COMMD1 VGNC VGNC:61074
Mus musculus COMMD1 MGD MGI:109474
Macaca mulatta COMMD1 VGNC VGNC:82130