SELENOM - selenoprotein M Gene

Homo sapiens

Also known as SELM; SEPM

Gene ID: 140606 | Gene type: protein coding

About SELENOM

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,104,777-31,107,568 (from NCBI)

This gene has 9 transcripts (splice variants), 186 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 54.6), endometrium (RPKM 49.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

SELENOM Products(1)

mRNA	Protein	Name
NM_080430.4	NP_536355.1	selenoprotein M precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOM Protein Structure

Sep15_SelM

0
100
145 a.a.

Protein Preferred Names

Protein Names

selenoprotein M

selenoprotein SelM

Recombinant SELENOM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71603	SELM Protein, Human	Q8WWX9 (A24-L145)	≥95%

Related Diseases

Diseases

Alias

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Cataract 8, Multiple Types

Ccv	Cataract, Congenital, Volkmann Type
CTRCT8	Cataract 8 Multiple Types
Cataract Congenital Volkmann Type	Cutaneous Collagenous Vasculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12638	SELENOM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELENOM	VGNC	VGNC:82552
Bos taurus	SELENOM	VGNC	VGNC:53920
Rattus norvegicus	SELENOM	RGD	RGD:1565037
Mus musculus	SELENOM	MGD	MGI:2149786
Others	SELENOM	NCBI

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