2. Gene
  3. F9 - coagulation factor IX Gene

F9 - coagulation factor IX Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cf9; Cf-9

Gene ID: 14071 | Gene type: protein coding

About F9

Summary

This gene encodes a vitamin K-dependent serine protease that plays a critical role in the intrinsic pathway of blood coagulation. The encoded protein is an inactive zymogen that is activated by coagulation factor XIa to generate factor IXa, a heterodimer containing heavy and light chains. In association with Factor VIII, membrane Phospholipids and calcium ions, factor IXa cleaves the inactive zymogen factor X to generate active Factor Xa. Genetic deletion of this gene in mice results in a severe bleeding phenotype. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

F9 Products(2)

mRNA Protein Name
NM_001305797.1 NP_001292726.1 coagulation factor IX isoform 2
NM_007979.2 NP_032005.1 coagulation factor IX isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
15178576 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within blood coagulation IMP
IMP: Inferred from mutant phenotype
15178576 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor IX

christmas factor

Recombinant F9 Proteins

Cat. No. Product Name Accession Purity
HY-P74240 Coagulation Factor IX/F9 Protein, Mouse (HEK293, His) P16294 (A29-T471) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14649G Retinoic acid (GMP) Agonist / Phase 3
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99029 Magrolimab Inhibitor 96.40% Phase 3
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13589 Cemadotin Inhibitor / Unkown
HY-155741 CB2 PET Radioligand 1 / Unkown
HY-158320 T3SS-IN-5 / Unkown
HY-162131 Antitumor agent-132 / Unkown
HY-RS04648 F9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99145 Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) Inhibitor 99.60% Unkown
HY-P99232 Indusatumab / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F9 NCBI NCBI:2158
Canis familiaris F9 NCBI NCBI:404015
Macaca fascicularis F9 NCBI NCBI:102146175
Canis lupus familiaris F9 NCBI
Leporidae F9 NCBI
Rattus norvegicus F9 NCBI NCBI:24946
Macaca mulatta F9 NCBI NCBI:695578