2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. Retinoic acid

Retinoic acid  (Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA)

Cat. No.: HY-14649G
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Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors.

For research use only. We do not sell to patients.

Retinoic acid Chemical Structure

Retinoic acid Chemical Structure

CAS No. : 302-79-4

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10 mg USD 1200 In-stock
50 mg USD 3580 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 63 publication(s) in Google Scholar

Other Forms of Retinoic acid:

Retinoic acid Related Antibodies

Top Publications Citing Use of Products

60 Publications Citing Use of MCE Retinoic acid

WB

    Retinoic acid purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150.  [Abstract]

    Cell morphology of MCF-7 treated with RA (20 μM)+ω-3 PUFAs (80 μM) with or without 3-MA (5 mM) for 24h.

    Retinoic acid purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150.  [Abstract]

    Cells are treated with RA (20 μM) plus ω-3 PUFAs (80 μM) with or without CQ (5 μM) for 24 h. Cell extracts are prepared and subjected to western blotting analysis.

    Retinoic acid purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150.  [Abstract]

    MCF-7 cells are pretreated with the indicated chemical inhibitors for 30min, followed by 15 min treatment with RA (20 μM) + EPA (80 μM).Cell extracts are prepared and subjected to western blotting analysis.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors[1][2][3][4][5][6].

    In Vitro

    Retinoic acid (GMP) time- and dose- dependently induces differentiation of EC cells and ES cells into specific cell types[1].
    Retinoic acid (GMP) induces partial differentiation of F9 embryonal carcinoma cells into endoderm cells[2].
    Retinoic acid (GMP) (100 nM; 2-8 d) promotes photoreceptor differentiation in early postnatal retinal cultures[3].
    Retinoic acid (GMP) (0.1 μM; 10-12 d) induces human SH-SY5Y neuroblastoma cells differentiation with long cell processes[4].
    Retinoic acid (GMP) (0-10 μM; 48 h) dose-dependently induces morphologic differentiation of LA-N-1 human neuroblastoma cells[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Retinoic acid Related Antibodies
    In Vivo

    Retinoic acid (GMP) (0.3 μM; embryos are immersed in tank water containing retinoic acid) accelerates of rod differentiation is observed following 24 and 48 hours of application in zebrafish[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    300.44

    Formula

    C20H28O2
    CAS No.
    Appearance

    Solid

    Color

    Light brown to yellow

    SMILES

    CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C(O)=O)=C(C)CCC1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (166.42 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3285 mL 16.6423 mL 33.2845 mL
    5 mM 0.6657 mL 3.3285 mL 6.6569 mL
    View the Complete Stock Solution Preparation Table

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    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.3285 mL 16.6423 mL 33.2845 mL 83.2113 mL
    5 mM 0.6657 mL 3.3285 mL 6.6569 mL 16.6423 mL
    10 mM 0.3328 mL 1.6642 mL 3.3285 mL 8.3211 mL
    15 mM 0.2219 mL 1.1095 mL 2.2190 mL 5.5474 mL
    20 mM 0.1664 mL 0.8321 mL 1.6642 mL 4.1606 mL
    25 mM 0.1331 mL 0.6657 mL 1.3314 mL 3.3285 mL
    30 mM 0.1109 mL 0.5547 mL 1.1095 mL 2.7737 mL
    40 mM 0.0832 mL 0.4161 mL 0.8321 mL 2.0803 mL
    50 mM 0.0666 mL 0.3328 mL 0.6657 mL 1.6642 mL
    60 mM 0.0555 mL 0.2774 mL 0.5547 mL 1.3869 mL
    80 mM 0.0416 mL 0.2080 mL 0.4161 mL 1.0401 mL
    100 mM 0.0333 mL 0.1664 mL 0.3328 mL 0.8321 mL
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    Retinoic acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Retinoic acid (GMP)302-79-4Vitamin A acid (GMP) all-trans-Retinoic acid (GMP) ATRA (GMP)RAR/RXRRetinoic acid receptorsRetinoid X receptorsGMPdifferentiationECESF9 embryonal carcinoma cellSH-SY5Y neuroblastomaneuroblastomaInhibitorinhibitorinhibit

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