2. Gene
  3. SREK1 - splicing regulatory glutamic acid and lysine rich protein 1 Gene

SREK1 - splicing regulatory glutamic acid and lysine rich protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SFRS12; SRrp86; SRrp508

Gene ID: 140890 | Gene type: protein coding

About SREK1

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:66,144,300-66,183,615 (from NCBI)

This gene has 16 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 19.8), thyroid (RPKM 10.9) and 25 other tissues.

Summary

This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with Other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

SREK1 Products(8)

mRNA Protein Name
NM_001077199.3 NP_001070667.1 splicing regulatory glutamine/lysine-rich protein 1 isoform a
NM_001270492.2 NP_001257421.1 splicing regulatory glutamine/lysine-rich protein 1 isoform c
NM_001323527.2 NP_001310456.1 splicing regulatory glutamine/lysine-rich protein 1 isoform b
NM_001323529.2 NP_001310458.1 splicing regulatory glutamine/lysine-rich protein 1 isoform e
NM_001323533.2 NP_001310462.1 splicing regulatory glutamine/lysine-rich protein 1 isoform f
NM_001323534.2 NP_001310463.1 splicing regulatory glutamine/lysine-rich protein 1 isoform g
NM_001323535.2 NP_001310464.1 splicing regulatory glutamine/lysine-rich protein 1 isoform h
NM_139168.4 NP_631907.1 splicing regulatory glutamine/lysine-rich protein 1 isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23602568 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SREK1 Protein Structure

(68 - 136)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

splicing regulatory glutamine/lysine-rich protein 1

serine-arginine-rich splicing regulatory protein 508

SREK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SREK1 Q8WXA9 SRSF11 Homo sapiens Q05519
Validated Y2H
25416956
Intra
SREK1 Q8WXA9 SRSF11 Homo sapiens Q05519-2
Y2H Array
32296183
Intra
SREK1 Q8WXA9 SRSF11 Homo sapiens Q05519-2
Y2H Prey Pooling
32296183
Intra
SREK1 Q8WXA9 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
Intra
SREK1 Q8WXA9 TXLNA Homo sapiens P40222
Y2H Array
32296183
Intra
SREK1 Q8WXA9 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
Intra
SREK1 Q8WXA9 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
SREK1 Q8WXA9 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
SREK1 Q8WXA9 SRPK1 Homo sapiens Q96SB4
Protein Kinase Assay
23602568
Intra
SREK1 Q8WXA9 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13759 SREK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SREK1 VGNC VGNC:58417
Canis familiaris SREK1 VGNC VGNC:46797
Macaca mulatta SREK1 VGNC VGNC:77944
Mus musculus SREK1 MGD MGI:2145245
Rattus norvegicus SREK1 RGD RGD:621696