ADPRH - ADP-ribosylarginine hydrolase Gene

Homo sapiens

Also known as ARH1; hARH1

Gene ID: 141 | Gene type: protein coding

About ADPRH

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,579,492-119,589,945 (from NCBI)

This gene has 7 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues.

Summary

The Enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse Enzymes that require DTT for maximal activity, the human Enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

ADPRH Products(5)

mRNA	Protein	Name
NM_001125.4	NP_001116.1	ADP-ribosylarginine hydrolase isoform 1
NM_001291949.2	NP_001278878.1	ADP-ribosylarginine hydrolase isoform 1
NM_001291950.2	NP_001278879.1	ADP-ribosylarginine hydrolase isoform 2
NM_001371092.1	NP_001358021.1	ADP-ribosylarginine hydrolase isoform 1
NM_001391992.1	NP_001378921.1	ADP-ribosylarginine hydrolase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP-ribosylarginine hydrolase activity	IDA IDA: Inferred from direct assay	30472116	GOA
enables ADP-ribosylarginine hydrolase activity	IMP IMP: Inferred from mutant phenotype	8349667	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	19407395	GOA
enables potassium ion binding	IDA IDA: Inferred from direct assay	19407395	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein de-ADP-ribosylation	IDA IDA: Inferred from direct assay	30472116	GOA
involved in protein modification process	IMP IMP: Inferred from mutant phenotype	8349667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADPRH Protein Structure

ADP_ribosyl_GH

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylarginine hydrolase

ADP-ribose-L-arginine cleaving enzyme

Recombinant ADPRH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7462	ADPRH/ARH1 Protein, Human (His)	P54922 (M1-L357)	≥95%

Related Diseases

Diseases

Alias

Tyrosinemia

Hypertyrosinemia	Tyrosinemias
Hereditary Tyrosinemia	Hypertyrosinaemia
Tyrosinaemia	Hereditary Hypertyrosinemia

Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY	Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency
Hypermethioninemia Due To Gnmt Deficiency	Hypermethioninemia
Hepatic Methionine Adenosyltransferase Deficiency

Mucolipidosis Ii Alpha/Beta

I-Cell Disease	Mucolipidosis Type Ii
Mucolipidosis Ii	Icd
Inclusion Cell Disease	Inclusion-Cell Disease
I Cell Disease	Mucolipidosis 2
MLII	Ml Ii
Ml Ii Alpha/Beta	Gnpta
Leroy Disease	Ml 2
Ml Disorder Type 2	N-Acetylglucosamine 1phosphotransferase Deficiency
Mucolipidosis Type Ii Alpha/Beta	N-Acetylglucosamine 1-Phosphotransferase Deficiency
Deficiency Of N-Acetylglucosamine-1-Phosphotransferase	Mucolipidosis, Type Ii, Alpha/Beta
Ml2	Type Ii Mucolipidosis

Sphingolipidosis

Sphingolipidoses

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Leukodystrophy

Leukodystrophies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00404	ADPRH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADPRH	RGD	RGD:2052
Bos taurus	ADPRH	VGNC	VGNC:25690
Mus musculus	ADPRH	MGD	MGI:1098234
Macaca mulatta	ADPRH	VGNC	VGNC:110386
Canis familiaris	ADPRH	VGNC	VGNC:37670
Others	ADPRH	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.