SPSB1 - splA/ryanodine receptor domain and SOCS box containing 1 Gene

Homo sapiens

Also known as SSB1; SSB-1

Gene ID: 80176 | Gene type: protein coding

About SPSB1

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,292,894-9,369,532 (from NCBI)

This gene has 4 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 16.9), gall bladder (RPKM 15.1) and 24 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SPSB1 Products(1)

mRNA	Protein	Name
NM_025106.4	NP_079382.2	SPRY domain-containing SOCS box protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20561531	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IPI IPI: Inferred from physical interaction	21199876	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	21199876	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21199876	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21199876	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPSB1 Protein Structure

SPRY

SOCS_box

0
100
200
273 a.a.

Protein Preferred Names

Protein Names

SPRY domain-containing SOCS box protein 1

SPRY domain-containing SOCS box protein SSB-1

SPSB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPSB1	Q96BD6	SNAI1	Homo sapiens	O95863	Anti Tag CoIP	25203322
Intra	SPSB1	Q96BD6	PAK1	Homo sapiens	Q13153	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	PAK1	Homo sapiens	Q13153	Y2H Array	32814053
Intra	SPSB1	Q96BD6	PAK1	Homo sapiens	Q13153	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	SPSB1	Q96BD6	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	SUV39H1	Homo sapiens	O43463	Y2H	23455924
Intra	SPSB1	Q96BD6	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	SPSB1	Q96BD6	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	SPSB1	Q96BD6	HIP1	Homo sapiens	O00291	Y2H Array	32814053
Intra	SPSB1	Q96BD6	HIP1	Homo sapiens	O00291	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	HIP1	Homo sapiens	O00291	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	PAWR	Homo sapiens	Q96IZ0	ITC	20561531
Intra	SPSB1	Q96BD6	CCK	Homo sapiens	P06307	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	CCK	Homo sapiens	P06307	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	CCK	Homo sapiens	P06307	Y2H Array	32814053
Intra	SPSB1	Q96BD6	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	SPSB1	Q96BD6	KDM1A	Homo sapiens	O60341	Anti Tag CoIP	23455924
Intra	SPSB1	Q96BD6	HMOX2	Homo sapiens	P30519	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	HMOX2	Homo sapiens	P30519	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	HMOX2	Homo sapiens	P30519	Y2H Array	32814053
Intra	SPSB1	Q96BD6	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	SPSB1	Q96BD6	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	SPSB1	Q96BD6	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	SPSB1	Q96BD6	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	SPSB1	Q96BD6	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	23455924
Intra	SPSB1	Q96BD6	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924
Cross	SPSB1	Q96BD6	vas	Drosophila melanogaster	P09052	ITC	20561531

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Muscular Dystrophy-Dystroglycanopathy A7

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A7	Mddga7
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease Ispd-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13726	SPSB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPSB1	MGD	MGI:1921896
Canis familiaris	SPSB1	VGNC	VGNC:46770
Felis catus	SPSB1	VGNC	VGNC:65654
Macaca mulatta	SPSB1	VGNC	VGNC:78024
Rattus norvegicus	SPSB1	RGD	RGD:1309319

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