Fer - fer (fms/fps related) protein kinase Gene

Mus musculus

Also known as Fer; Fert; Fert2; C330004K01Rik

Gene ID: 14158 | Gene type: protein coding

About Fer

Summary

Enables protein kinase activity and protein Phosphatase 1 binding activity. Involved in several processes, including cell surface receptor signaling pathway; cell-cell adhesion mediated by cadherin; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including cell adhesion; chemotaxis; and protein autophosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with several cellular components, including chromatin; cytoskeleton; and lamellipodium. Is expressed in central nervous system and retina. Orthologous to human FER (FER tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fer Products(6)

mRNA	Protein	Name
NM_001037997.4	NP_001033086.2	tyrosine-protein kinase Fer isoform a
NM_001286415.1	NP_001273344.1	tyrosine-protein kinase Fer isoform c
NM_001403359.1	NP_001390288.1	tyrosine-protein kinase Fer isoform d
NM_001403360.1	NP_001390289.1	tyrosine-protein kinase Fer isoform d
NM_001403361.1	NP_001390290.1	tyrosine-protein kinase Fer isoform e
NM_008000.2	NP_032026.2	tyrosine-protein kinase Fer isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12200133	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	12192036	MGI
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	16732323	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Fc-epsilon receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12192036	MGI
involved in Kit signaling pathway	IMP IMP: Inferred from mutant phenotype	12192036	MGI
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16176974	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	12192036	MGI
involved in cell-cell adhesion mediated by cadherin	IMP IMP: Inferred from mutant phenotype	16176974	MGI
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	17606629	MGI
acts upstream of or within chemotaxis	IMP IMP: Inferred from mutant phenotype	12192036	MGI
involved in diapedesis	IMP IMP: Inferred from mutant phenotype	16009680	MGI
involved in extracellular matrix-cell signaling	IMP IMP: Inferred from mutant phenotype	17606629	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	11006284	MGI
involved in negative regulation of mast cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	16731527	MGI
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	7623846	MGI
acts upstream of positive effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	11006284	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	12192036	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12192036	MGI
involved in regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	17606629	MGI
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16732323	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	16009680	MGI
involved in response to platelet-derived growth factor	IDA IDA: Inferred from direct assay	7623846	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	12192036	MGI
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	16176974	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase Fer

fer (fms/fps related) protein kinase, testis specific 2	p94-Fer
proto-oncogene c-Fer	proto-oncogene tyrosine-protein kinase Fer

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122844	Ifebemtinib	Inhibitor	99.86%	Phase 2
HY-10338A	Foretinib phosphate	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100579	Ferrostatin-1	Inhibitor	99.96%	Unkown
HY-123919	TL13-112	Inhibitor	98.15%	Unkown
HY-112097	E260	Inhibitor	99.05%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-128576	DS21360717		99.80%	Unkown
HY-122582	TL13-12	Inhibitor	98.06%	Unkown
HY-116087	SRS11-92	Inhibitor	99.92%	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-156066	Ferrostatin-1 diyne	Inhibitor	/	Unkown
HY-161731	DS08701581	Inhibitor	/	Unkown
HY-RS04862	FER Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04863	FER1L6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fer	NCBI	NCBI:2241
Canis familiaris	Fer	NCBI	NCBI:403754
Felis catus	Fer	NCBI	NCBI:101094235
Macaca fascicularis	Fer	NCBI	NCBI:102143808
Canis lupus familiaris	Fer	NCBI
Susscrofa domestica	Fer	NCBI
Rattus norvegicus	Fer	NCBI	NCBI:301737
Macaca mulatta	Fer	NCBI	NCBI:711220

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