2. Gene
  3. Fer - FER tyrosine kinase Gene

Fer - FER tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Flk; Fert2; Flk_retired

Gene ID: 301737 | Gene type: protein coding

About Fer

Summary

Enables several functions, including cadherin binding activity; Enzyme binding activity; and gamma-catenin binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; regulation of cell migration; and regulation of mast cell activation involved in immune response. Predicted to act upstream of or within protein autophosphorylation and signal transduction. Predicted to be located in cytosol and nucleus. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with several cellular components, including chromatin; cytoskeleton; and lamellipodium. Orthologous to human FER (FER tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fer Products(2)

mRNA Protein Name
NM_001106928.1 NP_001100398.1 tyrosine-protein kinase Fer isoform 1
NM_001395758.1 NP_001382687.1 tyrosine-protein kinase Fer isoform 2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in adherens junction assembly IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in adherens junction disassembly IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in germ cell development IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12700184 RGD
involved in seminiferous tubule development IEP
IEP: Inferred from expression pattern
12700184 RGD
Cellular Component GO Annotation Evidence Reference Source
located in adherens junction IDA
IDA: Inferred from direct assay
12700184 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12700184 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Fer

c-FER

fer (fms/fps related) protein kinase, testis specific 2

fer (fps/fes related) tyrosine kinase

p94-FER

proto-oncogene c-Fer

proto-oncogene tyrosine-protein kinase FER

tyrosine protein kinase FLK

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-122844 Ifebemtinib Inhibitor 99.86% Phase 2
HY-10338A Foretinib phosphate Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100579 Ferrostatin-1 Inhibitor 99.96% Unkown
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-112097 E260 Inhibitor 99.05% Unkown
HY-148063 DB0614 98.80% Unkown
HY-148061 DB1113 99.28% Unkown
HY-128576 DS21360717 99.80% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-116087 SRS11-92 Inhibitor 99.92% Unkown
HY-136194 TL13-22 Inhibitor 99.71% Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-156066 Ferrostatin-1 diyne Inhibitor / Unkown
HY-161731 DS08701581 Inhibitor / Unkown
HY-RS04862 FER Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04863 FER1L6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fer NCBI NCBI:2241
Canis familiaris Fer NCBI NCBI:403754
Felis catus Fer NCBI NCBI:101094235
Macaca fascicularis Fer NCBI NCBI:102143808
Canis lupus familiaris Fer NCBI
Mus musculus Fer NCBI NCBI:14158
Susscrofa domestica Fer NCBI
Macaca mulatta Fer NCBI NCBI:711220