2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. TL13-22

TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells.

For research use only. We do not sell to patients.

TL13-22 Chemical Structure

TL13-22 Chemical Structure

CAS No. : 2229036-65-9

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5 mg USD 998 In-stock
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Based on 1 publication(s) in Google Scholar

TL13-22 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1].

IC50 & Target

IC50: 0.54 nM (ALK)[1]
In Vitro

TL13-22 prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 11.3 nM, 5.74 nM, 18.4 nM, and 65.9 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TL13-22 Related Antibodies
Molecular Weight

947.50

Formula

C45H55ClN10O9S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C(OC)=C2)CC1)CNC5=CC=CC(C(N6C7C(NCCC7)=O)=O)=C5C6=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (263.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0554 mL 5.2770 mL 10.5541 mL
5 mM 0.2111 mL 1.0554 mL 2.1108 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0554 mL 5.2770 mL 10.5541 mL 26.3852 mL
5 mM 0.2111 mL 1.0554 mL 2.1108 mL 5.2770 mL
10 mM 0.1055 mL 0.5277 mL 1.0554 mL 2.6385 mL
15 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7590 mL
20 mM 0.0528 mL 0.2639 mL 0.5277 mL 1.3193 mL
25 mM 0.0422 mL 0.2111 mL 0.4222 mL 1.0554 mL
30 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8795 mL
40 mM 0.0264 mL 0.1319 mL 0.2639 mL 0.6596 mL
50 mM 0.0211 mL 0.1055 mL 0.2111 mL 0.5277 mL
60 mM 0.0176 mL 0.0880 mL 0.1759 mL 0.4398 mL
80 mM 0.0132 mL 0.0660 mL 0.1319 mL 0.3298 mL
100 mM 0.0106 mL 0.0528 mL 0.1055 mL 0.2639 mL
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TL13-22 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TL13-222229036-65-9Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246TL13-12negativecontrolAurora AFERPTK2RPS6KA1Inhibitorinhibitorinhibit

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HY-136194
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