Fgfr2 - fibroblast growth factor receptor 2 Gene

Mus musculus

Also known as Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; Fgfr2b; KGFRTr

Gene ID: 14183 | Gene type: protein coding

About Fgfr2

Chromosome 7: 129,764,181-132,725,079 reverse strand.GRCm39:CM001000.3

This gene has 27 transcripts (splice variants), 219 orthologues, 53 paralogues and is associated with 278 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 15.2), lung adult (RPKM 13.2) and 25 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity. Involved in Fibroblast Growth Factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; reproductive organ Cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 Products(3)

mRNA	Protein	Name
NM_010207.2	NP_034337.2	fibroblast growth factor receptor 2 isoform IIIc
NM_201601.2	NP_963895.2	fibroblast growth factor receptor 2 isoform IIIb
NM_001347638.1	NP_001334567.1	fibroblast growth factor receptor 2 isoform 3

Fgfr2 Protein Structure

IgI_2_FGFR

IgI_3_FGFR2

PTKc_FGFR2

0
200
400
600
840 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 2

keratinocyte growth factor receptor

Recombinant Fgfr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76339	FGFR-2 Protein, Mouse (HEK293, Fc)	E9Q5C3 (R22-E263)	≥95%
HY-P76340	FGFR-2 Protein, Mouse (HEK293, His)	E9Q5C3/AAA39377.1 (R22-E263)	≥95%
HY-P77661	FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His)	P21803-2 (P39-E263)	≥95%

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-50904	Nintedanib	Inhibitor	99.94%	Yes
HY-18708	Erdafitinib	Inhibitor	99.66%	Unkown
HY-13311	Infigratinib	Inhibitor	99.72%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-100818	Futibatinib	Inhibitor	99.65%	Unkown
HY-11106	Nintedanib esylate	Inhibitor	99.95%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-N0060	Ferulic acid	Inhibitor	99.87%	Yes
HY-13311A	Infigratinib phosphate	Inhibitor	99.74%	Yes

Clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13330	Fexagratinib	Inhibitor	99.85%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-15391	Lucitanib	Inhibitor	98.94%	Phase 3
HY-101568	Roblitinib	Inhibitor	99.74%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.82%	Phase 2
HY-19981	Derazantinib	Inhibitor	99.28%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-10987A	ENMD-2076	Inhibitor	99.12%	Phase 2
HY-10987	ENMD-2076 Tartrate	Inhibitor	99.42%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-13304	LY2874455	Inhibitor	98.03%	Phase 1
HY-119367	ODM-203	Inhibitor	99.91%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-19983	ASP5878	Inhibitor	99.69%	Phase 1
HY-100491	H3B-6527	Inhibitor	≥98.0%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99007	Aprutumab	Inhibitor	96.50%	Phase 1

Pre-clinical Phase

Bioactive Molecules (42)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0183	Formononetin	Inhibitor	99.92%	Unkown
HY-147250	Lirafugratinib	Inhibitor	99.67%	Unkown
HY-12823	BLU9931	Inhibitor	99.97%	Unkown
HY-122704A	Surfen dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-17601	Alofanib	Inhibitor	99.90%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-15599	SSR128129E	Inhibitor	99.85%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.28%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-147250A	Lirafugratinib hydrochloride	Inhibitor	98.73%	Unkown
HY-101466	E7090	Inhibitor	99.64%	Unkown
HY-131908	CPL304110	Inhibitor	99.85%	Unkown
HY-149843	LC-MB12	Inhibitor	99.23%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-18603	FIIN-3	Inhibitor	99.66%	Unkown
HY-12965	S49076	Inhibitor	99.44%	Unkown
HY-131704	FGFR4-IN-5	Inhibitor	98.03%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-162626	FGFR2 degrader 1	Degrader	/	Unkown
HY-162865	FGFR2-IN-3	Inhibitor	/	Unkown
HY-158248	FGFR4-IN-19	Inhibitor	/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-148597	FGFR-IN-10	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-150652	FGFR-IN-8	Inhibitor	/	Unkown
HY-147715	FGFR3-IN-3	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-101544	ARQ 069	Inhibitor	/	Unkown
HY-N9507	Picrasidine Q	Inhibitor	/	Unkown
HY-163985	PROTAC FGFR2 degrader 1	Degrader	/	Unkown
HY-117595	PHM16	Inhibitor	/	Unkown
HY-145230	FGFR2-IN-1	Inhibitor	99.78%	Unkown
HY-147713	FGFR3-IN-1	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-164459	AZ8010	Inhibitor	/	Unkown
HY-15599A	SSR128129E free acid	Inhibitor	/	Unkown
HY-122704	Surfen	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-15391A	Lucitanib dihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr2	NCBI	NCBI:2263

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