Fgfr2 - fibroblast growth factor receptor 2 Gene

Mus musculus

Also known as Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; Fgfr2b; KGFRTr

Gene ID: 14183 | Gene type: protein coding

About Fgfr2

Chromosome 7: 129,764,181-132,725,079 reverse strand.GRCm39:CM001000.3

This gene has 27 transcripts (splice variants), 219 orthologues, 53 paralogues and is associated with 278 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 15.2), lung adult (RPKM 13.2) and 25 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity. Involved in Fibroblast Growth Factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; reproductive organ Cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 Products(3)

mRNA	Protein	Name
NM_010207.2	NP_034337.2	fibroblast growth factor receptor 2 isoform IIIc
NM_201601.2	NP_963895.2	fibroblast growth factor receptor 2 isoform IIIb
NM_001347638.1	NP_001334567.1	fibroblast growth factor receptor 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	9435295	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8393815	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	17202188	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	17951031	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	12756187	MGI
acts upstream of or within bone morphogenesis	IMP IMP: Inferred from mutant phenotype	10518547	MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11731698	MGI
acts upstream of or within branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	17951031	MGI
acts upstream of or within bud elongation involved in lung branching	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of cell division	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	15509736	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within coronal suture morphogenesis	IMP IMP: Inferred from mutant phenotype	19389359	MGI
acts upstream of or within digestive tract development	IMP IMP: Inferred from mutant phenotype	15234214	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within embryonic organ morphogenesis	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within endodermal digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	21550054	MGI
acts upstream of or within epidermis morphogenesis	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15972105	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9435295	MGI
involved in fibroblast growth factor receptor signaling pathway involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	20345253	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification	IMP IMP: Inferred from mutant phenotype	16720875	MGI
involved in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	IMP IMP: Inferred from mutant phenotype	20345253	MGI
involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
involved in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	IMP IMP: Inferred from mutant phenotype	20345253	MGI
acts upstream of or within gland morphogenesis	IMP IMP: Inferred from mutant phenotype	17202188	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	17687036	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	10934262	MGI
acts upstream of or within lacrimal gland development	IMP IMP: Inferred from mutant phenotype	10821755	MGI
acts upstream of or within lateral sprouting from an epithelium	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within lens fiber cell development	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within lens fiber cell development	IMP IMP: Inferred from mutant phenotype	23136392	MGI
acts upstream of or within limb bud formation	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within lung alveolus development	IGI IGI: Inferred from genetic interaction	16989802	MGI
acts upstream of or within lung alveolus development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10518547	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within lung-associated mesenchyme development	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of or within lung-associated mesenchyme development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within mammary gland bud formation	IMP IMP: Inferred from mutant phenotype	11782400	MGI
acts upstream of or within membranous septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16687131	MGI
acts upstream of or within mesenchymal cell differentiation	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of or within mesenchymal cell differentiation involved in lung development	IGI IGI: Inferred from genetic interaction	16989802	MGI
acts upstream of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within mesenchymal cell proliferation involved in lung development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	17687036	MGI
acts upstream of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within negative regulation of mitotic nuclear division	IGI IGI: Inferred from genetic interaction	18455718	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	17418794	MGI
acts upstream of or within odontogenesis	IMP IMP: Inferred from mutant phenotype	17951031	MGI
involved in orbitofrontal cortex development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within otic vesicle formation	IMP IMP: Inferred from mutant phenotype	9435295	MGI
acts upstream of or within outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16687131	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	17202188	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16720875	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	18187602	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15972105	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21492869	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within positive regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16989802	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of urothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within prostate epithelial cord elongation	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18184727	MGI
involved in pyramidal neuron development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within regulation of morphogenesis of a branching structure	IMP IMP: Inferred from mutant phenotype	17202188	MGI
acts upstream of or within regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	12756187	MGI
acts upstream of or within regulation of smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	16989802	MGI
acts upstream of or within regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16618415	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	12666202	MGI
acts upstream of or within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	IMP IMP: Inferred from mutant phenotype	17215304	MGI
acts upstream of or within stem cell differentiation	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	14530295	MGI
acts upstream of or within synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	17418794	MGI
acts upstream of or within ureteric bud development	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of urothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15843416	MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	16687131	MGI
involved in ventricular zone neuroblast division	IMP IMP: Inferred from mutant phenotype	20410112	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in excitatory synapse	IMP IMP: Inferred from mutant phenotype	20410112	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15229180	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr2 Protein Structure

IgI_2_FGFR

IgI_3_FGFR2

PTKc_FGFR2

0
200
400
600
840 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor 2

keratinocyte growth factor receptor

Recombinant Fgfr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76339	FGFR-2 Protein, Mouse (HEK293, Fc)	E9Q5C3 (R22-E263)	≥95%
HY-P76340	FGFR-2 Protein, Mouse (HEK293, His)	E9Q5C3/AAA39377.1 (R22-E263)	≥95%
HY-P77661	FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His)	P21803-2 (P39-E263)	≥95%

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10981	Lenvatinib	Inhibitor	99.75%	Yes
HY-50904	Nintedanib	Inhibitor	99.94%	Yes
HY-18708	Erdafitinib	Inhibitor	99.66%	Unkown
HY-13311	Infigratinib	Inhibitor	99.72%	Yes
HY-109099	Pemigatinib	Inhibitor	99.84%	Yes
HY-100818	Futibatinib	Inhibitor	99.65%	Unkown
HY-11106	Nintedanib esylate	Inhibitor	99.96%	Yes
HY-10981A	Lenvatinib mesylate	Inhibitor	99.86%	Yes
HY-N0060	Ferulic acid	Inhibitor	99.97%	Yes
HY-13311A	Infigratinib phosphate	Inhibitor	99.74%	Yes

Clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13330	Fexagratinib	Inhibitor	99.85%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-15391	Lucitanib	Inhibitor	98.94%	Phase 3
HY-101568	Roblitinib	Inhibitor	99.74%	Phase 2
HY-13034	Gandotinib	Inhibitor	99.58%	Phase 2
HY-19981	Derazantinib	Inhibitor	99.28%	Phase 2
HY-10987A	ENMD-2076	Inhibitor	99.12%	Phase 2
HY-19957	Zoligratinib	Inhibitor	99.76%	Phase 2
HY-10987	ENMD-2076 Tartrate	Inhibitor	99.42%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-159642	TYRA-300	Inhibitor	/	Phase 2
HY-101466A	E7090 succinate	Inhibitor	99.17%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-13304	LY2874455	Inhibitor	98.03%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-119367	ODM-203	Inhibitor	99.91%	Phase 1
HY-19983	ASP5878	Inhibitor	99.69%	Phase 1
HY-100491	H3B-6527	Inhibitor	≥98.0%	Phase 1
HY-131908	CPL304110	Inhibitor	99.85%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99007	Aprutumab	Inhibitor	96.50%	Phase 1

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0183	Formononetin	Inhibitor	98.99%	Unkown
HY-147250	Lirafugratinib	Inhibitor	99.67%	Unkown
HY-12823	BLU9931	Inhibitor	99.97%	Unkown
HY-122704A	Surfen dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-17601	Alofanib	Inhibitor	99.90%	Unkown
HY-18602	FIIN-2	Inhibitor	99.32%	Unkown
HY-15599	SSR128129E	Inhibitor	99.85%	Unkown
HY-148779	FGFR3-IN-5	Inhibitor	99.28%	Unkown
HY-145231	FGFR2-IN-2	Inhibitor	98.25%	Unkown
HY-101466	E7090	Inhibitor	99.64%	Unkown
HY-147250A	Lirafugratinib hydrochloride	Inhibitor	98.73%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-149843	LC-MB12	Inhibitor	99.23%	Unkown
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-18603	FIIN-3	Inhibitor	99.66%	Unkown
HY-12965	S49076	Inhibitor	99.44%	Unkown
HY-131704	FGFR4-IN-5	Inhibitor	98.03%	Unkown
HY-145230	FGFR2-IN-1	Inhibitor	99.78%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-168286	FGFR-IN-16	Inhibitor	/	Unkown
HY-142921	FGFR-IN-2	Inhibitor	/	Unkown
HY-163985	PROTAC FGFR2 degrader 1	Degrader	/	Unkown
HY-162865	FGFR2-IN-3	Inhibitor	/	Unkown
HY-158248	FGFR4-IN-19	Inhibitor	/	Unkown
HY-151903S	FGFR2/3-IN-1	Inhibitor	/	Unkown
HY-147713	FGFR3-IN-1	Inhibitor	/	Unkown
HY-141685	3-Methylthienyl-carbonyl-JNJ-7706621	Inhibitor	/	Unkown
HY-N9507	Picrasidine Q	Inhibitor	/	Unkown
HY-162626	FGFR2 degrader 1	Degrader	/	Unkown
HY-101544	ARQ 069	Inhibitor	/	Unkown
HY-117595	PHM16	Inhibitor	/	Unkown
HY-148597	FGFR-IN-10	Inhibitor	/	Unkown
HY-147715	FGFR3-IN-3	Inhibitor	/	Unkown
HY-150652	FGFR-IN-8	Inhibitor	/	Unkown
HY-152104	FGFR-IN-9	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-155028	FGFR-IN-11	Inhibitor	/	Unkown
HY-15599A	SSR128129E free acid	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-122704	Surfen	Inhibitor	/	Unkown
HY-15391A	Lucitanib dihydrochloride	Inhibitor	/	Unkown
HY-164459	AZ8010	Inhibitor	/	Unkown
HY-159642G	TYRA-300 (GMP)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr2	NCBI	NCBI:2263

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