1. Gene
  2. Fgfr2 - fibroblast growth factor receptor 2 Gene

Fgfr2 - fibroblast growth factor receptor 2 Gene

Mus musculus

Also known as Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; Fgfr2b; KGFRTr

Gene ID: 14183 | Gene type: protein coding

About Fgfr2

Chromosome 7: 129,764,181-132,725,079 reverse strand.GRCm39:CM001000.3

This gene has 27 transcripts (splice variants), 219 orthologues, 53 paralogues and is associated with 278 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 15.2), lung adult (RPKM 13.2) and 25 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity. Involved in Fibroblast Growth Factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; reproductive organ Cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 Products(3)

mRNA Protein Name
NM_010207.2 NP_034337.2 fibroblast growth factor receptor 2 isoform IIIc
NM_201601.2 NP_963895.2 fibroblast growth factor receptor 2 isoform IIIb
NM_001347638.1 NP_001334567.1 fibroblast growth factor receptor 2 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables fibroblast growth factor binding IDA
IDA: Inferred from direct assay
9435295 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8393815 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
17202188 MGI
acts upstream of or within angiogenesis IGI
IGI: Inferred from genetic interaction
16778080 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12666202 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
17951031 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
12756187 MGI
acts upstream of or within bone morphogenesis IMP
IMP: Inferred from mutant phenotype
10518547 MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis IGI
IGI: Inferred from genetic interaction
15972105 MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15972105 MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: Inferred from mutant phenotype
9435295 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
12666202 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
11731698 MGI
acts upstream of or within branching morphogenesis of a nerve IMP
IMP: Inferred from mutant phenotype
17951031 MGI
acts upstream of or within bud elongation involved in lung branching IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18533146 MGI
acts upstream of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
15621532 MGI
acts upstream of cell division IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within cell fate commitment IDA
IDA: Inferred from direct assay
15509736 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16778080 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within cell-cell signaling IMP
IMP: Inferred from mutant phenotype
15199404 MGI
acts upstream of or within coronal suture morphogenesis IMP
IMP: Inferred from mutant phenotype
19389359 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
15234214 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
9435295 MGI
acts upstream of or within embryonic organ morphogenesis IMP
IMP: Inferred from mutant phenotype
15843416 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of or within endodermal digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
21550054 MGI
acts upstream of or within epidermis morphogenesis IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
15972105 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15199404 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IGI
IGI: Inferred from genetic interaction
15972105 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IMP
IMP: Inferred from mutant phenotype
15972105 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
24058167 MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16720875 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15621532 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9435295 MGI
involved in fibroblast growth factor receptor signaling pathway involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
20345253 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification IMP
IMP: Inferred from mutant phenotype
16720875 MGI
involved in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell IMP
IMP: Inferred from mutant phenotype
20345253 MGI
involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development IMP
IMP: Inferred from mutant phenotype
20410112 MGI
involved in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow IMP
IMP: Inferred from mutant phenotype
20345253 MGI
acts upstream of or within gland morphogenesis IMP
IMP: Inferred from mutant phenotype
17202188 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
17687036 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9435295 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
10934262 MGI
acts upstream of or within lacrimal gland development IMP
IMP: Inferred from mutant phenotype
10821755 MGI
acts upstream of or within lateral sprouting from an epithelium IMP
IMP: Inferred from mutant phenotype
12666202 MGI
acts upstream of or within lens fiber cell development IGI
IGI: Inferred from genetic interaction
18455718 MGI
acts upstream of or within lens fiber cell development IMP
IMP: Inferred from mutant phenotype
23136392 MGI
acts upstream of or within limb bud formation IMP
IMP: Inferred from mutant phenotype
9435295 MGI
acts upstream of or within lung alveolus development IGI
IGI: Inferred from genetic interaction
16989802 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
16540513 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10518547 MGI
acts upstream of or within lung lobe morphogenesis IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within lung-associated mesenchyme development IGI
IGI: Inferred from genetic interaction
18533146 MGI
acts upstream of or within lung-associated mesenchyme development IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within mammary gland bud formation IMP
IMP: Inferred from mutant phenotype
11782400 MGI
acts upstream of or within membranous septum morphogenesis IMP
IMP: Inferred from mutant phenotype
16687131 MGI
acts upstream of or within mesenchymal cell differentiation IGI
IGI: Inferred from genetic interaction
16442091 MGI
acts upstream of or within mesenchymal cell differentiation involved in lung development IGI
IGI: Inferred from genetic interaction
16989802 MGI
acts upstream of mesenchymal cell proliferation IGI
IGI: Inferred from genetic interaction
16540513 MGI
acts upstream of or within mesenchymal cell proliferation involved in lung development IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
17687036 MGI
acts upstream of mitotic nuclear division IGI
IGI: Inferred from genetic interaction
18455718 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
15843416 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
18455718 MGI
acts upstream of or within negative regulation of mitotic nuclear division IGI
IGI: Inferred from genetic interaction
18455718 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
17418794 MGI
acts upstream of or within odontogenesis IMP
IMP: Inferred from mutant phenotype
17951031 MGI
involved in orbitofrontal cortex development IMP
IMP: Inferred from mutant phenotype
20410112 MGI
acts upstream of or within organ growth IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of or within otic vesicle formation IMP
IMP: Inferred from mutant phenotype
9435295 MGI
acts upstream of or within outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
16687131 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
17202188 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18533146 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16720875 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
15621532 MGI
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
20410112 MGI
acts upstream of or within positive regulation of cell division IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18187602 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20410112 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
15972105 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15199404 MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21492869 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IGI
IGI: Inferred from genetic interaction
16540513 MGI
acts upstream of or within positive regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
16540513 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16989802 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20410112 MGI
acts upstream of or within positive regulation of urothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15843416 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
IMP: Inferred from mutant phenotype
17215304 MGI
acts upstream of or within prostate epithelial cord elongation IMP
IMP: Inferred from mutant phenotype
17215304 MGI
acts upstream of or within prostate gland morphogenesis IMP
IMP: Inferred from mutant phenotype
18184727 MGI
involved in pyramidal neuron development IMP
IMP: Inferred from mutant phenotype
20410112 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
17215304 MGI
acts upstream of or within regulation of morphogenesis of a branching structure IMP
IMP: Inferred from mutant phenotype
17202188 MGI
acts upstream of or within regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
12756187 MGI
acts upstream of or within regulation of smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
16989802 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
16618415 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
12666202 MGI
acts upstream of or within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development IMP
IMP: Inferred from mutant phenotype
17215304 MGI
acts upstream of or within stem cell differentiation IGI
IGI: Inferred from genetic interaction
16442091 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
16540513 MGI
acts upstream of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
14530295 MGI
acts upstream of or within synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
17418794 MGI
acts upstream of or within ureteric bud development IGI
IGI: Inferred from genetic interaction
16442091 MGI
acts upstream of urothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15843416 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
16687131 MGI
involved in ventricular zone neuroblast division IMP
IMP: Inferred from mutant phenotype
20410112 MGI
Cellular Component GO Annotation Evidence Reference Source
located in excitatory synapse IMP
IMP: Inferred from mutant phenotype
20410112 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15229180 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr2 Protein Structure

Ig

Ig: cl11960 (49 - 142)

Ig

Ig: cd00096 (76 - 80)

Ig

Ig: cd00096 (87 - 91)

Ig

Ig: cd00096 (108 - 112)

Ig

Ig: cd00096 (122 - 127)

Ig

Ig: cd00096 (135 - 138)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (172 - 175)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (172 - 266)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (183 - 188)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (192 - 200)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (206 - 211)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (214 - 216)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (225 - 228)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (232 - 237)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (246 - 253)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (256 - 266)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (274 - 378)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (274 - 277)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (281 - 285)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (293 - 300)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (304 - 311)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (326 - 331)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (343 - 348)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (356 - 364)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (367 - 375)

PTKc_FGFR2

PTKc_FGFR2: cd05101 (474 - 786)

  • 0
  • 200
  • 400
  • 600
  • 840 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor receptor 2

keratinocyte growth factor receptor

Recombinant Fgfr2 Proteins

Cat. No. Product Name Accession Purity
HY-P76339 FGFR-2 Protein, Mouse (HEK293, Fc) E9Q5C3 (R22-E263) ≥95%
HY-P76340 FGFR-2 Protein, Mouse (HEK293, His) E9Q5C3/AAA39377.1 (R22-E263) ≥95%
HY-P77661 FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His) P21803-2 (P39-E263) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgfr2 NCBI NCBI:2263