2. Gene
  3. Folr1 - folate receptor 1 (adult) Gene

Folr1 - folate receptor 1 (adult) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as FBP1; Folbp1; Folbp-1

Gene ID: 14275 | Gene type: protein coding

About Folr1

Summary

Predicted to enable carboxylic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in circulatory system development; nervous system development; and regulation of signal transduction. Acts upstream of or within folic acid metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Predicted to be anchored component of plasma membrane. Predicted to be anchored component of external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Folr1 Products(16)

mRNA Protein Name
NM_001252552.2 NP_001239481.1 folate receptor alpha precursor
NM_001252553.2 NP_001239482.1 folate receptor alpha precursor
NM_001252554.2 NP_001239483.1 folate receptor alpha precursor
NM_001412428.1 NP_001399357.1 folate receptor alpha precursor
NM_001412429.1 NP_001399358.1 folate receptor alpha precursor
NM_001412430.1 NP_001399359.1 folate receptor alpha precursor
NM_001412431.1 NP_001399360.1 folate receptor alpha precursor
NM_001412432.1 NP_001399361.1 folate receptor alpha precursor
NM_001412433.1 NP_001399362.1 folate receptor alpha precursor
NM_001412434.1 NP_001399363.1 folate receptor alpha precursor
NM_001412435.1 NP_001399364.1 folate receptor alpha precursor
NM_001412436.1 NP_001399365.1 folate receptor alpha precursor
NM_001412437.1 NP_001399366.1 folate receptor alpha precursor
NM_001412438.1 NP_001399367.1 folate receptor alpha precursor
NM_001412439.1 NP_001399368.1 folate receptor alpha precursor
NM_008034.4 NP_032060.2 folate receptor alpha precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in anterior neural tube closure IMP
IMP: Inferred from mutant phenotype
17286298 MGI
involved in axon regeneration IMP
IMP: Inferred from mutant phenotype
20424322 MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
17286298 MGI
acts upstream of or within folic acid metabolic process IMP
IMP: Inferred from mutant phenotype
12854656 MGI
involved in heart looping IMP
IMP: Inferred from mutant phenotype
17286298 MGI
involved in neural crest cell migration involved in heart formation IMP
IMP: Inferred from mutant phenotype
17286298 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: Inferred from mutant phenotype
17286298 MGI
involved in regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
21649587 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21649587 MGI
involved in response to axon injury IMP
IMP: Inferred from mutant phenotype
20424322 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

folate receptor alpha

FR-alpha

folate-binding protein 1

Recombinant Folr1 Proteins

Cat. No. Product Name Accession Purity
HY-P70344 FOLR1 Protein, Mouse (HEK293, His) P35846 (T25-S232) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132258A Mirvetuximab soravtansine (solution) / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99225 Mirvetuximab 99.76% Phase 3
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05029 FOLR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Folr1 NCBI NCBI:2348
Canis familiaris Folr1 NCBI
Macaca fascicularis Folr1 NCBI NCBI:102132305
Rattus norvegicus Folr1 NCBI NCBI:171049
Macaca mulatta Folr1 NCBI NCBI:718388