FOLR1 - folate receptor alpha Gene

Homo sapiens

Also known as FBP; FOLR; NCFTD; FRalpha

Gene ID: 2348 | Gene type: protein coding

About FOLR1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,189,709-72,196,323 (from NCBI)

This gene has 5 transcripts (splice variants), 222 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in lung (RPKM 83.5), kidney (RPKM 59.8) and 4 other tissues.

Summary

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

FOLR1 Products(4)

mRNA	Protein	Name
NM_000802.3	NP_000793.1	folate receptor alpha precursor
NM_016724.3	NP_057936.1	folate receptor alpha precursor
NM_016725.3	NP_057937.1	folate receptor alpha precursor
NM_016729.3	NP_057941.1	folate receptor alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables folic acid binding	IDA IDA: Inferred from direct assay	2527252	GOA
enables folic acid receptor activity	IMP IMP: Inferred from mutant phenotype	8033114	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to folic acid	IDA IDA: Inferred from direct assay	14722620	GOA
involved in folic acid transport	IMP IMP: Inferred from mutant phenotype	8033114	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10787414	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10787414	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	2527252	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23243496	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOLR1 Protein Structure

Folate_rec

0
100
200
257 a.a.

Protein Preferred Names

Protein Names

folate receptor alpha

FR-alpha

FOLR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOLR1	P15328	SLC35F6	Homo sapiens	Q8N357	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FOLR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70296	FOLR1 Protein, Human (HEK293, His)	P15328 (R25-S234)	≥95%
HY-P72371	FOLR1 Protein, Human (Biotinylated, HEK293, His-Avi)	P15328 (R25-S234)	≥95%
HY-P78445	FOLR1 Protein, Human (HEK293, His-Avi)	P15328 (R25-M233)	≥95%

FOLR1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81354	Folate Binding Protein Antibody (YA1099)	IHC-P	Human

Related Diseases

Diseases

Alias

Neurodegeneration Due To Cerebral Folate Transport Deficiency

Cerebral Folate Transport Deficiency	Cerebral Folate Deficiency
NCFTD	Cerebral Folate Deficiency Syndrome
Folr1 Deficiency	Neurodegenerative Syndrome Due To Cerebral Folate Transport Deficiency

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Myelomeningocele

Meningomyelocele

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Choriocarcinoma Of The Testis

Testicular Choriocarcinoma

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption	Congenital Defect Of Folate Absorption
Congenital Folate Malabsorption	Folic Acid Transport Defect
HFM

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube

Leukodystrophy

Leukodystrophies

Serine Deficiency

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Epilepsy, Pyridoxine-Dependent

Pyridoxine-Dependent Epilepsy	PDE
Pyridoxine Dependency With Seizures	Vitamin B6-Dependent Seizures
EPD	Aasa Dehydrogenase Deficiency
Antiquitin Deficiency	Pyridoxine Dependency
Glutamate Decarboxylase Deficiency	Pyridoxine-Dependent Seizures
Deficiency Of Glutamate Decarboxylase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132258A	Mirvetuximab soravtansine (solution)		99.71%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99225	Mirvetuximab		99.88%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05029	FOLR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990935	Opugotamig		/	Unkown
HY-P990941	Rinatabart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FOLR1	VGNC	VGNC:102889
Macaca mulatta	FOLR1	VGNC	VGNC:72689
Rattus norvegicus	FOLR1	RGD	RGD:71032
Mus musculus	FOLR1	MGD	MGI:95568
Canis familiaris	FOLR1	NCBI
Macaca fascicularis	FOLR1	NCBI	NCBI:102132305
Others	FOLR1	NCBI

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