CRYZ - crystallin zeta Gene

Homo sapiens

Gene ID: 1429 | Gene type: protein coding

About CRYZ

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:74,705,486-74,733,050 (from NCBI)

This gene has 7 transcripts (splice variants), 230 orthologues and 17 paralogues. Broad expression in kidney (RPKM 99.6), liver (RPKM 48.8) and 23 other tissues.

Summary

Crystallins are separated into two classes: taxon-specific, or Enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

CRYZ Products(4)

mRNA	Protein	Name
NM_001130042.2	NP_001123514.1	quinone oxidoreductase isoform a
NM_001130043.2	NP_001123515.1	quinone oxidoreductase isoform b
NM_001134759.2	NP_001128231.1	quinone oxidoreductase isoform c
NM_001889.4	NP_001880.2	quinone oxidoreductase isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables NADH binding	IDA IDA: Inferred from direct assay	17497241	GOA
enables NADPH binding	IDA IDA: Inferred from direct assay	17497241	GOA
enables NADPH:quinone reductase activity	IDA IDA: Inferred from direct assay	17497241	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	17497241	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein homotetramerization	IPI IPI: Inferred from physical interaction	17497241	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	17497241	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17497241	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRYZ Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

quinone oxidoreductase

NADPH:quinone reductase

Related Diseases

Diseases

Alias

Septic Myocarditis

Geotrichosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03219	CRYZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CRYZ	VGNC	VGNC:82528
Mus musculus	CRYZ	MGD	MGI:88527
Rattus norvegicus	CRYZ	RGD	RGD:1311639
Bos taurus	CRYZ	VGNC	VGNC:27746

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