FAM76B - family with sequence similarity 76 member B Gene

Homo sapiens

Gene ID: 143684 | Gene type: protein coding

About FAM76B

This gene has 13 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.3), lymph node (RPKM 9.9) and 24 other tissues.

Summary

Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

FAM76B Products(2)

mRNA	Protein	Name
NM_001330357.2	NP_001317286.1	protein FAM76B isoform 2
NM_144664.5	NP_653265.3	protein FAM76B isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	19266028	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein FAM76B

FAM76B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FAM76B	Q5HYJ3	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-11	Homo sapiens	P60412	Y2H Array	25416956
Intra	FAM76B	Q5HYJ3	KRTAP10-11	Homo sapiens	P60412	Y2H Prey Pooling	25416956
Intra	FAM76B	Q5HYJ3	KRTAP4-7	Homo sapiens	Q9BYR0	Y2H Prey Pooling	25416956
Intra	FAM76B	Q5HYJ3	KRTAP4-7	Homo sapiens	Q9BYR0	Validated Y2H	25416956
Intra	FAM76B	Q5HYJ3	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	FAM76B	Q5HYJ3	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	25416956
Intra	FAM76B	Q5HYJ3	ADO	Homo sapiens	Q96SZ5	Anti Tag CoIP	28514442
Intra	FAM76B	Q5HYJ3	ADO	Homo sapiens	Q96SZ5	Anti Tag CoIP	33961781
Intra	FAM76B	Q5HYJ3	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17	Iddm17
Insulin-Dependent Diabetes Mellitus 17	TID17
Insulin-Dependent Diabetes Mellitus-17

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Carboxypeptidase N Deficiency

Anaphylotoxin Inactivator Deficiency	Deficiency Of Carboxypeptidase B
CPND

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04719	FAM76B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FAM76B	VGNC	VGNC:62124
Bos taurus	FAM76B	VGNC	VGNC:28828
Macaca mulatta	FAM76B	VGNC	VGNC:72389
Rattus norvegicus	FAM76B	RGD	RGD:1311077
Mus musculus	FAM76B	MGD	MGI:1920076
Canis familiaris	FAM76B	VGNC	VGNC:40694

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