SPINDOC - spindlin interactor and repressor of chromatin binding Gene

Homo sapiens

Also known as C11orf84; SPIN-DOC

Gene ID: 144097 | Gene type: protein coding

About SPINDOC

This gene has 3 transcripts (splice variants) and 93 orthologues. Broad expression in testis (RPKM 9.7), placenta (RPKM 7.2) and 23 other tissues.

Summary

Involved in negative regulation of transcription, DNA-templated. [provided by Alliance of Genome Resources, Apr 2022]

SPINDOC Products(1)

mRNA	Protein	Name
NM_138471.3	NP_612480.1	spindlin interactor and repressor of chromatin-binding protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IDA IDA: Inferred from direct assay	34737271	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	34737271	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	29061846	GOA
involved in regulation of protein ADP-ribosylation	IDA IDA: Inferred from direct assay	34737271	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	29061846	GOA
is active in site of DNA damage	IDA IDA: Inferred from direct assay	34737271	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

spindlin interactor and repressor of chromatin-binding protein

SPIN1 docking protein

SPINDOC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPINDOC	Q9BUA3	UQCRC1	Homo sapiens	P31930	Validated Y2H	32814053
Intra	SPINDOC	Q9BUA3	UQCRC1	Homo sapiens	P31930	Y2H Array	32814053
Intra	SPINDOC	Q9BUA3	UQCRC1	Homo sapiens	P31930	Y2H Pooling	32814053
Intra	SPINDOC	Q9BUA3	SPIN3	Homo sapiens	Q5JUX0	Anti Tag CoIP	33961781
Intra	SPINDOC	Q9BUA3	SPIN3	Homo sapiens	Q5JUX0	Anti Tag CoIP	28514442
Intra	SPINDOC	Q9BUA3	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	SPINDOC	Q9BUA3	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chondroid Lipoma

Soft Tissue Chondroma

Extraskeletal Chondroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13678	SPINDOC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPINDOC	MGD	MGI:2147611
Rattus norvegicus	SPINDOC	RGD	RGD:1308106
Bos taurus	SPINDOC	VGNC	VGNC:50753
Felis catus	SPINDOC	VGNC	VGNC:65639
Macaca mulatta	SPINDOC	VGNC	VGNC:77987

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