CSRP2 - cysteine and glycine rich protein 2 Gene

Homo sapiens

Also known as CRP2; LMO5; SmLIM

Gene ID: 1466 | Gene type: protein coding

About CSRP2

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,858,709-76,879,019 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 37.2), placenta (RPKM 35.3) and 23 other tissues.

Summary

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CSRP2 Products(9)

mRNA	Protein	Name
NM_001300965.2	NP_001287894.1	cysteine and glycine-rich protein 2 isoform b
NM_001321.3	NP_001312.1	cysteine and glycine-rich protein 2 isoform b
NM_001413535.1	NP_001400464.1	cysteine and glycine-rich protein 2 isoform b
NM_001413537.1	NP_001400466.1	cysteine and glycine-rich protein 2 isoform b
NM_001413538.1	NP_001400467.1	cysteine and glycine-rich protein 2 isoform b
NM_001413539.1	NP_001400468.1	cysteine and glycine-rich protein 2 isoform a
NM_001413540.1	NP_001400469.1	cysteine and glycine-rich protein 2 isoform c
NM_001413541.1	NP_001400470.1	cysteine and glycine-rich protein 2 isoform d
NM_001413542.1	NP_001400471.1	cysteine and glycine-rich protein 2 isoform e

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSRP2 Protein Structure

LIM

0
100
193 a.a.

Protein Preferred Names

Protein Names

cysteine and glycine-rich protein 2

LIM domain only 5, smooth muscle

CSRP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CSRP2	Q16527	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	CSRP2	Q16527	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	CSRP2	Q16527	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	CSRP2	Q16527	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	CSRP2	Q16527	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	CSRP2	Q16527	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	CSRP2	Q16527	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	CSRP2	Q16527	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	CSRP2	Q16527	ARC	Homo sapiens	Q7LC44	Validated Y2H	32296183
Intra	CSRP2	Q16527	ARC	Homo sapiens	Q7LC44	Y2H Prey Pooling	32296183
Intra	CSRP2	Q16527	ARC	Homo sapiens	Q7LC44	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 8q21.11 Deletion Syndrome

8q21.11 Microdeletion Syndrome	Del(8)(Q21.11)
Deletion 8q21.11	Monosomy 8q21.11

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03259	CSRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CSRP2	VGNC	VGNC:71528
Rattus norvegicus	CSRP2	RGD	RGD:61950
Bos taurus	CSRP2	VGNC	VGNC:27774
Felis catus	CSRP2	VGNC	VGNC:83862
Mus musculus	CSRP2	MGD	MGI:1202907

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