ARC - activity regulated cytoskeleton associated protein Gene

Homo sapiens

Also known as hArc; Arg3.1

Gene ID: 23237 | Gene type: protein coding

About ARC

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,611,049-142,614,479 (from NCBI)

This gene has 2 transcripts (splice variants) and 104 orthologues. Biased expression in adrenal (RPKM 5.5), brain (RPKM 5.4) and 9 other tissues.

Summary

Predicted to enable mRNA binding activity. Involved in cell migration; Cytoskeleton organization; and regulation of cell morphogenesis. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARC Products(2)

mRNA	Protein	Name
NM_001412852.1	NP_001399781.1	activity-regulated cytoskeleton-associated protein
NM_015193.5	NP_056008.1	activity-regulated cytoskeleton-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	33175445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	33175445	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21834987	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21834987	GOA
located in virus-like capsid	IDA IDA: Inferred from direct assay	33175445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

activity-regulated cytoskeleton-associated protein

ARC/ARG3.1

ARC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARC	Q7LC44	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Retrograde Amnesia

Amnesia, Retrograde

Amphetamine Abuse

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Amnestic Disorder

Amnesia	Amnestic Syndrome
Korsakoff'S Psychosis Or Syndrome	Amnesic Syndrome
Amnestic Disorder In Conditions Classified Elsewhere	Korsakoff Psychosis Or Syndrome, Nonalcoholic
Nonalcoholic Organic Amnesic Syndrome	Organic Amnesic Syndrome

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10064	Ticagrelor	Antagonist	99.98%	Yes
HY-147080	Avacincaptad pegol sodium	Inhibitor	98.53%	Unkown
HY-B0678	Metaxalone		99.77%	Unkown
HY-19638	Cangrelor	Antagonist	/	Unkown
HY-B0678R	Metaxalone (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147079	Egaptivon pegol	Inhibitor	92.75%	Phase 2
HY-153480	ARC19499	Inhibitor	93.65%	Phase 1
HY-19845	Ordopidine	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13248	AR-C155858	Inhibitor	99.62%	Unkown
HY-110126	AR-C118925XX	Antagonist	≥99.0%	Unkown
HY-12709A	ARC 239 dihydrochloride	Antagonist	99.57%	Unkown
HY-126112	Mephenoxalone		98.57%	Unkown
HY-12122A	AR-C102222 hydrochloride	Inhibitor	99.83%	Unkown
HY-N2673	5-Heptadecylresorcinol	Activator	99.83%	Unkown
HY-153785	NH2-C6-ARC186 sodium	Inhibitor	92.50%	Unkown
HY-153098	ARC186	Inhibitor	94.13%	Unkown
HY-153480A	ARC19499 sodium	Inhibitor	93.65%	Unkown
HY-153098A	ARC186 sodium	Inhibitor	94.13%	Unkown
HY-119996A	AR-C141990 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-12709	ARC 239		99.71%	Unkown
HY-77734	AR-C133913XX		99.76%	Unkown
HY-108633	BYK 49187	Inhibitor	/	Unkown
HY-108665	AR-C66096 tetrasodium	Antagonist	/	Unkown
HY-119996	AR-C141990		/	Unkown
HY-124270	Sibenadet hydrochloride	Agonist	/	Unkown
HY-146769	Antimalarial agent 11	Inhibitor	/	Unkown
HY-147079A	Egaptivon pegol sodium	Inhibitor	92.75%	Unkown
HY-153492A	Olpasiran sodium	Inhibitor	/	Unkown
HY-153610	ARC7		99.57%	Unkown
HY-153611	ARC12		≥99.0%	Unkown
HY-78542S	Deshydroxyethoxy Ticagrelor-d7		/	Unkown
HY-B0678S	Metaxalone-d3		≥98.0%	Unkown
HY-B0678S1	Metaxalone-d6		/	Unkown
HY-RS00890	ARC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114602	AR-C117977	Inhibitor	/	Unkown
HY-118942	Topovale	Inhibitor	/	Unkown
HY-12122	AR-C102222	Inhibitor	/	Unkown
HY-122048	AR-C67085		/	Unkown
HY-148826	Rovunaptabin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARC	VGNC	VGNC:26056
Macaca mulatta	ARC	VGNC	VGNC:69998
Rattus norvegicus	ARC	RGD	RGD:62037
Felis catus	ARC	VGNC	VGNC:105871
Mus musculus	ARC	MGD	MGI:88067
Macaca fascicularis	ARC	NCBI	NCBI:102130416
Canis lupus familiaris	ARC	NCBI
Others	ARC	NCBI

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