2. Gene
  3. TICAM1 - TIR domain containing adaptor molecule 1 Gene

TICAM1 - TIR domain containing adaptor molecule 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1

Gene ID: 148022 | Gene type: protein coding

About TICAM1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,815,932-4,831,712 (from NCBI)

This gene has 1 transcript (splice variant), 103 orthologues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 10.4), duodenum (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with Toll-like Receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an Antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]

TICAM1 Products(4)

mRNA Protein Name
NM_001385678.1 NP_001372607.1 TIR domain-containing adapter molecule 1 isoform 2
NM_001385679.1 NP_001372608.1 TIR domain-containing adapter molecule 1 isoform 3
NM_001385680.1 NP_001372609.1 TIR domain-containing adapter molecule 1 isoform 4
NM_182919.4 NP_891549.1 TIR domain-containing adapter molecule 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
12471095 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14982987 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
14530355 GOA
Biological Process GO Annotation Evidence Reference Source
involved in TRIF-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25636800 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
14982987 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
28049150 GOA
acts upstream of or within response to exogenous dsRNA IMP
IMP: Inferred from mutant phenotype
21266579 GOA
involved in toll-like receptor 3 signaling pathway IDA
IDA: Inferred from direct assay
12471095 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
12471095 GOA
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
12471095 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in early endosome IDA
IDA: Inferred from direct assay
17982077 GOA
is active in endosome IDA
IDA: Inferred from direct assay
18222170 GOA
is active in endosome membrane IDA
IDA: Inferred from direct assay
18222170 GOA
part of ripoptosome IDA
IDA: Inferred from direct assay
21737330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TICAM1 Protein Structure

RHIM

RHIM: RIP homotypic interaction motif (646 - 698)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
Protein Preferred Names Protein Names

TIR domain-containing adapter molecule 1

TIR domain containing adaptor inducing interferon-beta

Related Diseases

Diseases Alias
Encephalopathy, Acute, Infection-Induced 6

Herpes Simplex Encephalitis, Susceptibility To, 4

IIAE6

Herpes Simplex Encephalitis 4

Encephalopathy, Acute, Infection-Induced , Susceptibility To, 6

Encephalopathy, Acute, Infection-Induced, 6, Herpes-Specific

Encephalopathy, Acute, Infection-Induced, 6

Hse4
Herpes Simplex Encephalitis

Hse

Hsv Encephalitis

Hsve

Herpes Simplex Meningo-Encephalitis

Herpes Simplex Neuroinvasion

Herpes Simplex Virus Encephalitis

Herpetic Encephalitis

Herpes Encephalitis

Herpes Simplex Virus 1 Encephalitis
Hepatitis A

Viral Hepatitis A

Viral Hepatitis, Type A
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Ross River Fever

Ross River Virus Disease

Ross River Virus Infection
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14517 TICAM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TICAM1 VGNC VGNC:55000
Mus musculus TICAM1 MGD MGI:2147032
Macaca mulatta TICAM1 VGNC VGNC:79134
Rattus norvegicus TICAM1 RGD RGD:1590868
Felis catus TICAM1 VGNC VGNC:102714
Bos taurus TICAM1 VGNC VGNC:52887