1. Gene
  2. SRARP - steroid receptor associated and regulated protein Gene

SRARP - steroid receptor associated and regulated protein Gene

Homo sapiens

Also known as ERRF; C1orf64

Gene ID: 149563 | Gene type: protein coding

About SRARP

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,004,236-16,008,807 (from NCBI)

This gene has 1 transcript (splice variant) and 78 orthologues. Biased expression in endometrium (RPKM 2.9), salivary gland (RPKM 2.4) and 4 other tissues.

Summary

Enables Estrogen Receptor binding activity. Involved in positive regulation of intracellular Estrogen Receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SRARP Products(1)

mRNA Protein Name
NM_178840.4 NP_849162.1 steroid receptor-associated and regulated protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
27125460 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27125460 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22341523 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22341523 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRARP Protein Structure

DUF4654

DUF4654: Domain of unknown function (DUF4654) (32 - 169)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

steroid receptor-associated and regulated protein

ER-related factor

SRARP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SRARP Q8NEQ6 SLC4A2 Homo sapiens P04920 33961781
Intra
SRARP Q8NEQ6 WFS1 Homo sapiens O76024 32814053
Intra
SRARP Q8NEQ6 WFS1 Homo sapiens O76024 32814053
Intra
SRARP Q8NEQ6 WFS1 Homo sapiens O76024 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphocele

Lymph Cyst

Lymphocele Adverse Event

Peyronie'S Disease

Induratio Penis Plastica

Peyronie Disease

Peyronies Disease

Peyronie'S Fibromatosis

Penile Induration

Balanitis Xerotica Obliterans

Urethral Stricture

Ankylurethria

Urethral Stenosis

Urethral Contracture

Urethral Obstruction

Meatal Stenosis Nos

Constriction Of Urethra

Contraction Of Urethra

Stricture Of Urinary Meatus

Urethral Obliteration

Urethral Narrowing

Pinpoint Meatus

Pinhole Meatus Nos

Urethral Occlusion

Laryngomalacia

Congenital Laryngomalacia

Congenital Laryngeal Stridor

Laryngomalacia Congenital

Floppy Epiglottis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus SRARP VGNC VGNC:107639
Rattus norvegicus SRARP RGD RGD:1566083
Canis familiaris SRARP VGNC VGNC:46789
Mus musculus SRARP MGD MGI:2685540
Macaca mulatta SRARP VGNC VGNC:78008
Bos taurus SRARP VGNC VGNC:35267