NFAM1 - NFAT activating protein with ITAM motif 1 Gene

Homo sapiens

Also known as CNAIP

Gene ID: 150372 | Gene type: protein coding

About NFAM1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,380,407-42,437,986 (from NCBI)

This gene has 2 transcripts (splice variants) and 97 orthologues. Broad expression in bone marrow (RPKM 10.9), appendix (RPKM 7.1) and 16 other tissues.

Summary

The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]

NFAM1 Products(3)

mRNA	Protein	Name
NM_001318323.3	NP_001305252.1	NFAT activation molecule 1 isoform 2 precursor
NM_001371362.1	NP_001358291.1	NFAT activation molecule 1 isoform 3
NM_145912.8	NP_666017.1	NFAT activation molecule 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	12615919	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcineurin-NFAT signaling cascade	IDA IDA: Inferred from direct assay	12615919	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12615919	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	12615919	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	12615919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NFAT activation molecule 1

calcineurin/NFAT-activating ITAM-containing protein

NFAM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFAM1	Q8NET5	BCL11A	Homo sapiens	Q9H165-2	Validated Y2H	32296183
Intra	NFAM1	Q8NET5	BCL11A	Homo sapiens	Q9H165-2	Y2H Prey Pooling	32296183
Intra	NFAM1	Q8NET5	BCL11A	Homo sapiens	Q9H165-2	Y2H Array	32296183
Intra	NFAM1	Q8NET5	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	NFAM1	Q8NET5	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	NFAM1	Q8NET5	HSPA14	Homo sapiens	Q0VDF9	Anti Tag CoIP	33961781
Intra	NFAM1	Q8NET5	HSPA14	Homo sapiens	Q0VDF9	Anti Tag CoIP	28514442
Intra	NFAM1	Q8NET5	MAL2	Homo sapiens	Q969L2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Klippel-Feil Syndrome 4

Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria	Polymicrogyria, Bilateral Perisylvian
Pmgx	Perisylvian Syndrome, Congenital Bilateral
Cbps	Congenital Bilateral Perisylvian Syndrome
Perisylvian Syndrome	BPPX
Bpp

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09235	NFAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NFAM1	VGNC	VGNC:82493
Rattus norvegicus	NFAM1	RGD	RGD:1308316
Mus musculus	NFAM1	MGD	MGI:1921289
Bos taurus	NFAM1	VGNC	VGNC:32027
Macaca mulatta	NFAM1	VGNC	VGNC:75279
Canis familiaris	NFAM1	VGNC	VGNC:43763

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