2. Gene
  3. MAL2 - mal, T cell differentiation protein 2 Gene

MAL2 - mal, T cell differentiation protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 114569 | Gene type: protein coding

About MAL2

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,208,363-119,245,673 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues and 14 paralogues. Broad expression in esophagus (RPKM 140.3), thyroid (RPKM 100.0) and 16 other tissues.

Summary

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]

MAL2 Products(1)

mRNA Protein Name
NM_052886.3 NP_443118.1 protein MAL2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12963375 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane raft IDA
IDA: Inferred from direct assay
23264465 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAL2 Protein Structure

MARVEL

MARVEL: Membrane-associating domain (32 - 168)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

protein MAL2

MAL proteolipid protein 2

MAL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MAL2 Q969L2 SH3GL1 Homo sapiens Q6FGM0
Validated Y2H
25416956
Intra MAL2 Q969L2 SH3GL1 Homo sapiens Q6FGM0
Y2H Array
25416956
Intra MAL2 Q969L2 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra MAL2 Q969L2 PBX3 Homo sapiens Q5JS98
Y2H Array
25416956
Intra MAL2 Q969L2 PBX3 Homo sapiens Q5JS98
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 VARS2 Homo sapiens Q5ST30-3
Validated Y2H
25416956
Intra MAL2 Q969L2 TUBB Homo sapiens Q5SU16
Validated Y2H
25416956
Intra MAL2 Q969L2 TUBB Homo sapiens Q5SU16
Y2H Array
25416956
Intra MAL2 Q969L2 PTPN9 Homo sapiens Q6IQ43
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 FAM3A Homo sapiens Q9BU27
Validated Y2H
25416956
Intra MAL2 Q969L2 POLL Homo sapiens Q9UGP5-2
Validated Y2H
32296183
Intra MAL2 Q969L2 TARS2 Homo sapiens Q9BW92
Validated Y2H
32296183
Intra MAL2 Q969L2 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra MAL2 Q969L2 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra MAL2 Q969L2 NFAM1 Homo sapiens Q8NET5
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 NFAM1 Homo sapiens Q8NET5
Y2H Array
32296183
Intra MAL2 Q969L2 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra MAL2 Q969L2 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra MAL2 Q969L2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra MAL2 Q969L2 PITPNC1 Homo sapiens Q9UKF7-2
Validated Y2H
32296183
Intra MAL2 Q969L2 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra MAL2 Q969L2 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra MAL2 Q969L2 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra MAL2 Q969L2 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra MAL2 Q969L2 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra MAL2 Q969L2 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra MAL2 Q969L2 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 SUCLA2 Homo sapiens Q9P2R7
Validated Y2H
32296183
Intra MAL2 Q969L2 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32296183
Intra MAL2 Q969L2 CD68 Homo sapiens P34810
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 CD68 Homo sapiens P34810
Y2H Array
32296183
Intra MAL2 Q969L2 ARFIP2 Homo sapiens P53365
Validated Y2H
25416956
Intra MAL2 Q969L2 ARFIP2 Homo sapiens P53365
Y2H Array
25416956
Intra MAL2 Q969L2 ARFIP2 Homo sapiens P53365
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra MAL2 Q969L2 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra MAL2 Q969L2 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra MAL2 Q969L2 TBRG4 Homo sapiens Q969Z0
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Intra MAL2 Q969L2 MIEF1 Homo sapiens Q9NQG6
Validated Y2H
32296183
Intra MAL2 Q969L2 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra MAL2 Q969L2 PTPN9 Homo sapiens P43378
Y2H Array
31515488
Intra MAL2 Q969L2 GAD1 Homo sapiens Q99259
Validated Y2H
32296183
Intra MAL2 Q969L2 RAB37 Homo sapiens Q96AX2
Validated Y2H
25416956
Intra MAL2 Q969L2 RAB37 Homo sapiens Q96AX2
Y2H Array
25416956
Intra MAL2 Q969L2 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra MAL2 Q969L2 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra MAL2 Q969L2 MTERF3 Homo sapiens Q96E29
Validated Y2H
32296183
Intra MAL2 Q969L2 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra MAL2 Q969L2 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra MAL2 Q969L2 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra MAL2 Q969L2 GAD2 Homo sapiens Q05329
Y2H Prey Pooling
25416956
Intra MAL2 Q969L2 GAD2 Homo sapiens Q05329
Y2H Array
25416956
Intra MAL2 Q969L2 HSFX1 Homo sapiens Q9UBD0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Parasagittal Meningioma
Cerebral Convexity Meningioma

Cerebral Hemispheric Convexity Meningioma
Foster-Kennedy Syndrome

Disorder Of The Optic Nerve

Optic Nerve Diseases

Disease Of Optic Cranial Nerve

Disease Of Optic Nerve

Disease Of Second Cranial Nerve

Disorder Of Optic Cranial Nerve

Disorder Of Second Cranial Nerve

Disorders Of 2nd Nerve
Anterior Cranial Fossa Meningioma

Meningioma Of The Anterior Fossa
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-116683 116-9e Inhibitor 98.55% Unkown
HY-RS07992 MAL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAL2 VGNC VGNC:84015
Mus musculus MAL2 MGD MGI:2146021
Canis familiaris MAL2 VGNC VGNC:54900
Felis catus MAL2 VGNC VGNC:99808
Bos taurus MAL2 VGNC VGNC:54901
Rattus norvegicus MAL2 RGD RGD:735066