1. Gene
  2. Hck - hemopoietic cell kinase Gene

Hck - hemopoietic cell kinase Gene

Mus musculus

Also known as Bmk

Gene ID: 15162 | Gene type: protein coding

About Hck

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may play a role in the innate immune response and the STAT5 signaling pathway. Alternative translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq, Feb 2010]

Hck Products(2)

mRNA Protein Name
NM_001172117.1 NP_001165588.1 tyrosine-protein kinase HCK isoform p56Hck
NM_010407.4 NP_034537.2 tyrosine-protein kinase HCK isoform p59Hck
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12235133 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within defense response to Gram-positive bacterium IGI
IGI: Inferred from genetic interaction
8125254 MGI
acts upstream of or within phagocytosis IMP
IMP: Inferred from mutant phenotype
8125254 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase HCK

B cell/myeloid kinase

hematopoietic cell kinase

p56-HCK/p59-HCK

Hck Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross Hck P08103 WAS Homo sapiens P42768
Anti Tag CoIP
12235133
Cross Hck P08103 WAS Homo sapiens P42768
Protein Kinase Assay
12235133
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Hck NCBI NCBI:3055