HCK - HCK proto-oncogene, Src family tyrosine kinase Gene

Homo sapiens

Also known as JTK9; p59Hck; p61Hck

Gene ID: 3055 | Gene type: protein coding

About HCK

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,052,242-32,101,856 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 32 paralogues. Broad expression in appendix (RPKM 55.1), spleen (RPKM 40.9) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

HCK Products(6)

mRNA	Protein	Name
NM_001172129.3	NP_001165600.1	tyrosine-protein kinase HCK isoform b
NM_001172130.3	NP_001165601.1	tyrosine-protein kinase HCK isoform c
NM_001172131.3	NP_001165602.1	tyrosine-protein kinase HCK isoform d
NM_001172132.3	NP_001165603.1	tyrosine-protein kinase HCK isoform e
NM_001172133.3	NP_001165604.1	tyrosine-protein kinase HCK isoform b
NM_002110.5	NP_002101.2	tyrosine-protein kinase HCK isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lipid binding	EXP EXP: Inferred from Experiment	31877324	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7859737	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	10861086	GOA
enables protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	10092522	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	11904303	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17535448	GOA
involved in peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17535448	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11904303	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	10092522	GOA
involved in regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	11904303	GOA
involved in regulation of podosome assembly	IDA IDA: Inferred from direct assay	15998323	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	15998323	GOA
located in caveola	IDA IDA: Inferred from direct assay	7791757	GOA
located in cytoplasmic side of plasma membrane	IMP IMP: Inferred from mutant phenotype	11904303	GOA
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	11904303	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15998323	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase HCK

hematopoietic cell kinase

HCK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HCK	P08631	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	HCK	P08631	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	HCK	P08631	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	HCK	P08631	PAK2	Homo sapiens	Q13177	Phage Display	16374509
Intra	HCK	P08631	KHDRBS1	Homo sapiens	Q07666	Y2H	22641034
Intra	HCK	P08631	KHDRBS1	Homo sapiens	Q07666	Fluorescence Spectr	17141806
Intra	HCK	P08631	KIT	Homo sapiens	P10721	FPS	24728074
Intra	HCK	P08631	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	HCK	P08631	EGFR	Homo sapiens	P00533	PLA	23397142
Intra	HCK	P08631	SOS1	Homo sapiens	Q07889	PLA	23397142
Intra	HCK	P08631	PDCD6IP	Homo sapiens	Q8WUM4	Pull Down	22641034
Intra	HCK	P08631	WAS	Homo sapiens	P42768	Far-WB	19234535
Intra	HCK	P08631	WAS	Homo sapiens	P42768	Anti Bait CoIP	19234535
Intra	HCK	P08631	WAS	Homo sapiens	P42768	Pull Down	19234535
Intra	HCK	P08631	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	HCK	P08631	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	HCK	P08631	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	HCK	P08631	NLRP12	Homo sapiens	P59046	Anti Bait CoIP	32226298
Intra	HCK	P08631	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	HCK	P08631	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	HCK	P08631	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Cross	HCK	P08631	nef	Human immunodeficiency virus	Q90VU7	Phage Display	16374509
Intra	HCK	P08631	ADAM15	Homo sapiens	Q13444	Pull Down	11741929
Intra	HCK	P08631	ALOX5	Homo sapiens	P09917	Protein Kinase Assay	24860872
Intra	HCK	P08631	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	HCK	P08631	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Cross	HCK	P08631	nef	Human immunodeficiency virus	P03406	Pull Down	18042718
Cross	HCK	P08631	nef	Human immunodeficiency virus	P03406	Y2H	18042718
Cross	HCK	P08631	polg_hcv77	Hepatitis C virus	P27958	ELISA	15784897
Cross	HCK	P08631	polg_hcv77	Hepatitis C virus	P27958	Pull Down	14993658
Cross	HCK	P08631	polg_hcv77	Hepatitis C virus	P27958	Pull Down	15784897
Cross	HCK	P08631	polg_hcvj4	Hepatitis C virus	O92972	Pull Down	14993658
Cross	HCK	P08631	polg_hcvj4	Hepatitis C virus	O92972	ELISA	15784897
Cross	HCK	P08631	vif	Human immunodeficiency virus	P12504	Pull Down	11278465

Cross: Cross-species interaction Intra: Intraspecies interaction

HCK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83218	Tyrosine Protein Kinase HCK Antibody (YA2963)	WB, ICC/IF, IP	Human

Related Diseases

Diseases

Alias

Renal Pelvis Adenocarcinoma

Adenocarcinoma Of Renal Pelvis

Adenocarcinoma Of The Kidney Pelvis

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Cd45 Deficiency

Lung Clear Cell Carcinoma

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112852	TL02-59		99.84%	Unkown
HY-139147	iHCK-37	Inhibitor	99.52%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.80%	Unkown
HY-155657	BT424	Inhibitor	98.81%	Unkown
HY-P3279	EPQpYEEIPIYL	Activator	99.62%	Unkown
HY-D1694	LysoTracker Yellow HCK 123		98.51%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-120595	JNJ-49095397	Inhibitor	99.85%	Unkown
HY-15805	KIN-8194	Inhibitor	98.01%	Unkown
HY-125028	Hck-IN-1	Inhibitor	98.53%	Unkown
HY-123450	S116836		99.65%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-112852A	TL02-59 dihydrochloride		/	Unkown
HY-135216	Antiproliferative agent-54	Inhibitor	/	Unkown
HY-138562	HIV-1 Nef-IN-1	Inhibitor	98.60%	Unkown
HY-147314	HIV-IN-6	Inhibitor	98.35%	Unkown
HY-15268	PP487	Inhibitor	/	Unkown
HY-RS06044	HCK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HCK	VGNC	VGNC:29774
Rattus norvegicus	HCK	RGD	RGD:2785
Canis familiaris	HCK	VGNC	VGNC:41618
Mus musculus	HCK	MGD	MGI:96052
Felis catus	HCK	VGNC	VGNC:67542
Macaca mulatta	HCK	VGNC	VGNC:73353
Others	HCK	NCBI

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