1. Gene
  2. HCK - HCK proto-oncogene, Src family tyrosine kinase Gene

HCK - HCK proto-oncogene, Src family tyrosine kinase Gene

Homo sapiens

Also known as JTK9; p59Hck; p61Hck

Gene ID: 3055 | Gene type: protein coding

About HCK

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,052,242-32,101,856 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 32 paralogues. Broad expression in appendix (RPKM 55.1), spleen (RPKM 40.9) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

HCK Products(6)

mRNA Protein Name
NM_001172129.3 NP_001165600.1 tyrosine-protein kinase HCK isoform b
NM_001172130.3 NP_001165601.1 tyrosine-protein kinase HCK isoform c
NM_001172131.3 NP_001165602.1 tyrosine-protein kinase HCK isoform d
NM_001172132.3 NP_001165603.1 tyrosine-protein kinase HCK isoform e
NM_001172133.3 NP_001165604.1 tyrosine-protein kinase HCK isoform b
NM_002110.5 NP_002101.2 tyrosine-protein kinase HCK isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipid binding EXP
EXP: Inferred from Experiment
31877324 GOA
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7859737 GOA
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
10861086 GOA
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
10092522 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
11904303 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17535448 GOA
involved in peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
10092522 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
10092522 GOA
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
10092522 GOA
involved in regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
17535448 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11904303 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
10092522 GOA
involved in regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
11904303 GOA
involved in regulation of podosome assembly IDA
IDA: Inferred from direct assay
15998323 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with actin filament IDA
IDA: Inferred from direct assay
15998323 GOA
located in caveola IDA
IDA: Inferred from direct assay
7791757 GOA
located in cytoplasmic side of plasma membrane IMP
IMP: Inferred from mutant phenotype
11904303 GOA
located in focal adhesion IMP
IMP: Inferred from mutant phenotype
11904303 GOA
located in lysosome IDA
IDA: Inferred from direct assay
15998323 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HCK Protein Structure

SH3_1

SH3_1: SH3 domain (64 - 110)

SH2

SH2: SH2 domain (124 - 206)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (242 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase HCK

hematopoietic cell kinase

HCK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HCK P08631 KRT40 Homo sapiens Q6A162 25416956
Intra
HCK P08631 KRTAP10-9 Homo sapiens P60411 25416956
Intra
HCK P08631 KRTAP10-9 Homo sapiens P60411 25416956
Intra
HCK P08631 PAK2 Homo sapiens Q13177 16374509
Intra
HCK P08631 KHDRBS1 Homo sapiens Q07666
Y2H
22641034
Intra
HCK P08631 KHDRBS1 Homo sapiens Q07666 17141806
Intra
HCK P08631 KIT Homo sapiens P10721
FPS
24728074
Intra
HCK P08631 EGFR Homo sapiens P00533 24658140
Intra
HCK P08631 EGFR Homo sapiens P00533
PLA
23397142
Intra
HCK P08631 SOS1 Homo sapiens Q07889
PLA
23397142
Intra
HCK P08631 PDCD6IP Homo sapiens Q8WUM4 22641034
Intra
HCK P08631 WAS Homo sapiens P42768 19234535
Intra
HCK P08631 WAS Homo sapiens P42768 19234535
Intra
HCK P08631 WAS Homo sapiens P42768 19234535
Intra
HCK P08631 HSP90AB1 Homo sapiens P08238 32707033
Intra
HCK P08631 HSP90AB1 Homo sapiens P08238 31980649
Intra
HCK P08631 HSP90AB1 Homo sapiens P08238 22939624
Intra
HCK P08631 NLRP12 Homo sapiens P59046 32226298
Intra
HCK P08631 MTUS2 Homo sapiens Q5JR59 25416956
Intra
HCK P08631 MTUS2 Homo sapiens Q5JR59 25416956
Intra
HCK P08631 MTUS2 Homo sapiens Q5JR59 25416956
Cross
HCK P08631 nef Human immunodeficiency virus Q90VU7 16374509
Intra
HCK P08631 ADAM15 Homo sapiens Q13444 11741929
Intra
HCK P08631 ALOX5 Homo sapiens P09917 24860872
Intra
HCK P08631 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Intra
HCK P08631 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Cross
HCK P08631 nef Human immunodeficiency virus P03406 18042718
Cross
HCK P08631 nef Human immunodeficiency virus P03406
Y2H
18042718
Cross
HCK P08631 polg_hcv77 Hepatitis C virus P27958 15784897
Cross
HCK P08631 polg_hcv77 Hepatitis C virus P27958 14993658
Cross
HCK P08631 polg_hcv77 Hepatitis C virus P27958 15784897
Cross
HCK P08631 polg_hcvj4 Hepatitis C virus O92972 14993658
Cross
HCK P08631 polg_hcvj4 Hepatitis C virus O92972 15784897
Cross
HCK P08631 vif Human immunodeficiency virus P12504 11278465
Cross: Cross-species interaction Intra: Intraspecies interaction

HCK Antibodies

Cat. No. Product Name Application Reactivity
HY-P83218 Tyrosine Protein Kinase HCK Antibody (YA2963) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Renal Pelvis Adenocarcinoma

Adenocarcinoma Of Renal Pelvis

Adenocarcinoma Of The Kidney Pelvis

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Human Immunodeficiency Virus Type 1

Aids

Hiv/Aids

Aids, Delayed/Rapid Progression To

Hiv-1, Susceptibility To

Hiv-1 Viremia, Susceptibility To

Human Immunodeficiency Virus Type 1, Susceptibility To

Hiv-1

Aids, Slow Progression To

Rapid Progression To Aids From Hiv1 Infection

Hiv1 Infection, Resistance To

Hiv1 Infection

Hiv-1 Viremia

Aids, Resistance To

Aids, Rapid Progression To

Hiv/Aids, Susceptibility To

Hiv-1, Resistance To

Hiv1, Resistance To

Hiv1

Hiv-1 Disease, Delayed Progression Of

Hiv-1 Disease, Rapid Progression Of

Hiv Infection, Resistance To

Hiv Type 1, Susceptibility To

Hiv Type 1

Hiv-1 Infection

Human Immunodeficiency Virus I Infection

Acquired Immunodeficiency Syndrome

Hiv-Infection/Aids

Cd45 Deficiency
Lung Clear Cell Carcinoma
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus HCK VGNC VGNC:29774
Rattus norvegicus HCK RGD RGD:2785
Canis familiaris HCK VGNC VGNC:41618
Mus musculus HCK MGD MGI:96052
Felis catus HCK VGNC VGNC:67542
Macaca mulatta HCK VGNC VGNC:73353
Others HCK NCBI