Hic1 - hypermethylated in cancer 1 Gene

Mus musculus

Also known as HIC-1

Gene ID: 15248 | Gene type: protein coding

About Hic1

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hic1 Products(2)

mRNA	Protein	Name
NM_001098203.1	NP_001091673.1	hypermethylated in cancer 1 protein isoform 2
NM_010430.3	NP_034560.3	hypermethylated in cancer 1 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16269335	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	16269335	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16269335	MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	16269335	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	16269335	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hypermethylated in cancer 1 protein

Hic1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hic1	Q9R1Y5	Sirt1	Mus musculus	Q923E4	Anti Bait CoIP	16269335
Intra	Hic1	Q9R1Y5	Tcf7l2	Mus musculus	Q924A0	Anti Bait CoIP	16724116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W540188A	Calcium mesoxalate trihydrate		≥98.0%	Unkown
HY-RS06165	HIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hic1	NCBI	NCBI:3090

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