Tcf7l2 - transcription factor 7 like 2, T cell specific, HMG box Gene

Mus musculus

Also known as Tcf4; TCF4B; TCF4E; Tcf-4

Gene ID: 21416 | Gene type: protein coding

About Tcf7l2

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of Insulin secretion; regulation of transcription, DNA-templated; and response to glucose. Acts upstream of or within several processes, including animal organ development; negative regulation of cellular response to growth factor stimulus; and regulation of cellular biosynthetic process. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate Cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]

Tcf7l2 Products(31)

mRNA	Protein	Name
NM_001142918.2	NP_001136390.1	transcription factor 7-like 2 isoform 1
NM_001142919.2	NP_001136391.1	transcription factor 7-like 2 isoform 2
NM_001142920.2	NP_001136392.1	transcription factor 7-like 2 isoform 4
NM_001142921.2	NP_001136393.1	transcription factor 7-like 2 isoform 5
NM_001142922.2	NP_001136394.1	transcription factor 7-like 2 isoform 6
NM_001142923.2	NP_001136395.1	transcription factor 7-like 2 isoform 7
NM_001142924.2	NP_001136396.1	transcription factor 7-like 2 isoform 8
NM_001331135.1	NP_001318064.1	transcription factor 7-like 2 isoform 9
NM_001331136.1	NP_001318065.1	transcription factor 7-like 2 isoform 10
NM_001331137.1	NP_001318066.1	transcription factor 7-like 2 isoform 11
NM_001331138.1	NP_001318067.1	transcription factor 7-like 2 isoform 12
NM_001331139.1	NP_001318068.1	transcription factor 7-like 2 isoform 13
NM_001331140.1	NP_001318069.1	transcription factor 7-like 2 isoform 14
NM_001331141.1	NP_001318070.1	transcription factor 7-like 2 isoform 15
NM_001331142.1	NP_001318071.1	transcription factor 7-like 2 isoform 16
NM_001331143.1	NP_001318072.1	transcription factor 7-like 2 isoform 17
NM_001331144.1	NP_001318073.1	transcription factor 7-like 2 isoform 18
NM_001331145.1	NP_001318074.1	transcription factor 7-like 2 isoform 19
NM_001331146.1	NP_001318075.1	transcription factor 7-like 2 isoform 20
NM_001331147.1	NP_001318076.1	transcription factor 7-like 2 isoform 21
NM_001331148.1	NP_001318077.1	transcription factor 7-like 2 isoform 22
NM_001331149.1	NP_001318078.1	transcription factor 7-like 2 isoform 23
NM_001331150.1	NP_001318079.1	transcription factor 7-like 2 isoform 24
NM_001412695.1	NP_001399624.1	transcription factor 7-like 2 isoform 10
NM_001412705.1	NP_001399634.1	transcription factor 7-like 2 isoform 25
NM_001412706.1	NP_001399635.1	transcription factor 7-like 2 isoform 26
NM_001412707.1	NP_001399636.1	transcription factor 7-like 2 isoform 27
NM_001412708.1	NP_001399637.1	transcription factor 7-like 2 isoform 28
NM_001412710.1	NP_001399639.1	transcription factor 7-like 2 isoform 29
NM_001412711.1	NP_001399640.1	transcription factor 7-like 2 isoform 5
NM_009333.4	NP_033359.2	transcription factor 7-like 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20044351	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20044351	MGI
enables beta-catenin binding	IDA IDA: Inferred from direct assay	9784592	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	9488439	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17727834	MGI
enables chromatin binding	IGI IGI: Inferred from genetic interaction	23824574	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9488439	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20044351	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within bone mineralization	IGI IGI: Inferred from genetic interaction	19213727	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	9488439	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17699607	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	10937998	MGI
acts upstream of or within cellular response to starvation	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IGI IGI: Inferred from genetic interaction	15057272	MGI
acts upstream of or within embryonic genitalia morphogenesis	IGI IGI: Inferred from genetic interaction	15057272	MGI
acts upstream of or within embryonic hindgut morphogenesis	IGI IGI: Inferred from genetic interaction	15057272	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19251639	MGI
acts upstream of or within face morphogenesis	IGI IGI: Inferred from genetic interaction	17699607	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23028378	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within glycogen metabolic process	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	27996060	MGI
acts upstream of or within insulin metabolic process	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within intracellular glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23028378	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within myoblast fate commitment	IMP IMP: Inferred from mutant phenotype	10937998	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	10937998	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	15057272	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	17699607	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	19741146	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	17919533	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19168596	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17919533	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19251639	MGI
acts upstream of or within positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	23260145	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	19168596	MGI
acts upstream of or within positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20044351	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21335239	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15778706	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	23260145	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12861022	MGI
acts upstream of or within regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	23028378	MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19168596	MGI
acts upstream of or within regulation of myelination	IMP IMP: Inferred from mutant phenotype	19503085	MGI
acts upstream of or within regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19503085	MGI
acts upstream of or within regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	21177349	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19168596	MGI
involved in response to glucose	IMP IMP: Inferred from mutant phenotype	19168596	MGI
acts upstream of or within secretory granule localization	IMP IMP: Inferred from mutant phenotype	19168596	MGI
acts upstream of or within skin development	IGI IGI: Inferred from genetic interaction	19718027	MGI
acts upstream of or within somatic stem cell population maintenance	IGI IGI: Inferred from genetic interaction	19718027	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	9697701	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of catenin-TCF7L2 complex	IDA IDA: Inferred from direct assay	9488439	MGI
located in cytosol	IDA IDA: Inferred from direct assay	15578569	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9697701	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12861022	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor 7-like 2

HMG box transcription factor 4	HMG box transcription factor TCF7L2
T-cell-specific transcription factor 4

Tcf7l2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tcf7l2	Q924A0	Hic1	Mus musculus	Q9R1Y5	Anti Bait CoIP	16724116
Intra	Tcf7l2	Q924A0	Hic1	Mus musculus	Q9R1Y5	Anti Tag CoIP	16724116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W010995	2,5-Dimethylcelecoxib	Inhibitor	99.57%	Unkown
HY-N3628	Coronarin A	Inhibitor	≥98.0%	Unkown
HY-RS14310	TCF7L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf7l2	NCBI	NCBI:6934

Name
Email *

	Sorry, but the email address you supplied was invalid.