HIC1 - HIC ZBTB transcriptional repressor 1 Gene

Homo sapiens

Also known as hic-1; ZBTB29; ZNF901

Gene ID: 3090 | Gene type: protein coding

About HIC1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,055,103-2,063,241 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in fat (RPKM 8.9), endometrium (RPKM 4.9) and 19 other tissues.

Summary

This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]

HIC1 Products(2)

mRNA	Protein	Name
NM_001098202.1	NP_001091672.1	hypermethylated in cancer 1 protein isoform 2
NM_006497.4	NP_006488.2	hypermethylated in cancer 1 protein isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15231840	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15231840	GOA
enables histone deacetylase binding	IDA IDA: Inferred from direct assay	12052894	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12052894	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15231840	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	16269335	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	16724116	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12052894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIC1 Protein Structure

BTB

zf-C2H2_4

zf-C2H2

zf-H2C2_2

0
200
400
600
733 a.a.

Protein Preferred Names

Protein Names

hypermethylated in cancer 1 protein

hypermethylated in cancer 1

HIC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	HIC1	Q14526	Ctbp2	Mus musculus	P56546	Y2H	16762039
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Y2H	12052894
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Pull Down	12052894
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Anti Bait CoIP	16762039
Cross	HIC1	Q14526	Ctbp1	Mus musculus	O88712	Y2H	16762039
Intra	HIC1	Q14526	ARID1A	Homo sapiens	O14497	Y2H	19486893
Intra	HIC1	Q14526	CTBP2	Homo sapiens	P56545	Y2H	19486893
Intra	HIC1	Q14526	CTBP1	Homo sapiens	Q13363	Y2H	19486893
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Imaging	16724116
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Pull Down	16724116
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Anti Bait CoIP	16724116
Intra	HIC1	Q14526	TCF7L2	Homo sapiens	Q9NQB0	Anti Tag CoIP	16724116

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Bilateral Breast Cancer

Bilateral Breast Carcinoma

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Adult Cns Pnet

Adult Central Nervous System Primitive Neuroectodermal Tumor

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W540188A	Calcium mesoxalate trihydrate		≥98.0%	Unkown
HY-RS06165	HIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HIC1	VGNC	VGNC:99076
Canis familiaris	HIC1	VGNC	VGNC:41683
Mus musculus	HIC1	MGD	MGI:1338010
Rattus norvegicus	HIC1	RGD	RGD:1307527
Bos taurus	HIC1	VGNC	VGNC:29845

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