ZNF827 - zinc finger protein 827 Gene

Homo sapiens

Gene ID: 152485 | Gene type: protein coding

About ZNF827

Cytogenetic location: 4q31.21-q31.22 Genomic coordinates (GRCh38): 4:145,757,627-145,938,823 (from NCBI)

This gene has 22 transcripts (splice variants), 236 orthologues and 36 paralogues. Ubiquitous expression in prostate (RPKM 4.9), thyroid (RPKM 2.3) and 23 other tissues.

Summary

Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF827 Products(3)

mRNA	Protein	Name
NM_001306215.2	NP_001293144.1	zinc finger protein 827 isoform 1
NM_001410850.1	NP_001397779.1	zinc finger protein 827 isoform 3
NM_178835.5	NP_849157.2	zinc finger protein 827 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NuRD complex binding	IDA IDA: Inferred from direct assay	25150861	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25150861	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	25150861	GOA
involved in establishment of protein localization to telomere	IMP IMP: Inferred from mutant phenotype	25150861	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	33174841	GOA
involved in negative regulation of shelterin complex assembly	IMP IMP: Inferred from mutant phenotype	25150861	GOA
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	25150861	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	33174841	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	25150861	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	33174841	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF827 Protein Structure

zf-H2C2_2

zf-C2H2

zf-H2C2_5

zf-C2H2_4

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400
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800
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1081 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 827

ZNF827 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF827	Q17R98	MTA2	Homo sapiens	O94776	Anti Bait CoIP	25150861
Intra	ZNF827	Q17R98	HDAC2	Homo sapiens	Q92769	Anti Bait CoIP	25150861
Intra	ZNF827	Q17R98	RBBP7	Homo sapiens	Q16576	Anti Bait CoIP	25150861
Intra	ZNF827	Q17R98	CHD4	Homo sapiens	Q14839	Anti Bait CoIP	25150861
Intra	ZNF827	Q17R98	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	ZNF827	Q17R98	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	ZNF827	Q17R98	GATAD2B	Homo sapiens	Q8WXI9	Anti Bait CoIP	25150861

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16177	ZNF827 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZNF827	MGD	MGI:2444807
Bos taurus	ZNF827	VGNC	VGNC:55765
Macaca mulatta	ZNF827	VGNC	VGNC:100288
Rattus norvegicus	ZNF827	RGD	RGD:1560620
Felis catus	ZNF827	VGNC	VGNC:80125
Canis familiaris	ZNF827	VGNC	VGNC:106620

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