HDAC2 - histone deacetylase 2 Gene

Homo sapiens

Also known as HD2; RPD3; YAF1; KDAC2

Gene ID: 3066 | Gene type: protein coding

About HDAC2

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:113,933,028-113,971,148 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 14.8), endometrium (RPKM 10.6) and 25 other tissues.

Summary

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

HDAC2 Products(4)

mRNA	Protein	Name
NR_033441.2
NR_073443.2
NM_001527.4	NP_001518.3	histone deacetylase 2
XM_047418692.1	XP_047274648.1	histone deacetylase 2 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	17785205	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17827154	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11062478	GOA
enables histone binding	IDA IDA: Inferred from direct assay	19276356	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	16642021	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	28046085	GOA
enables histone decrotonylase activity	IDA IDA: Inferred from direct assay	28497810	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9150135	GOA
enables protein de-2-hydroxyisobutyrylase activity	IDA IDA: Inferred from direct assay	29192674	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	19041327	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in heterochromatin formation	IMP IMP: Inferred from mutant phenotype	19372552	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19041327	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19041327	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	19276356	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18347167	GOA
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	19041327	GOA
acts upstream of positive regulation of signaling receptor activity	IMP IMP: Inferred from mutant phenotype	18316616	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19041327	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	20075857	GOA
part of NuRD complex	IDA IDA: Inferred from direct assay	17827154	GOA
part of Sin3-type complex	IDA IDA: Inferred from direct assay	14966270	GOA
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	25150861	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24970816	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	9651585	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18347167	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	28046085	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC2 Protein Structure

Hist_deacetyl

0
100
200
300
400
488 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 2

YY1-associated factor 1	protein deacylase HDAC2
transcriptional regulator homolog RPD3

HDAC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	HDAC2	Q92769	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Pull Down	33060197
Intra	HDAC2	Q92769	ZNF516	Homo sapiens	Q92618	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Crosslink	26949739
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	22416134
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	9150135
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Crosslink	26949739
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Pull Down	16254079
Intra	HDAC2	Q92769	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	SUV39H1	Homo sapiens	O43463	Pull Down	12711603
Intra	HDAC2	Q92769	MYC	Homo sapiens	P01106	Display Tech	20195357
Intra	HDAC2	Q92769	BCL11B	Homo sapiens	Q9C0K0	Anti Tag CoIP	17245431
Intra	HDAC2	Q92769	BCL11B	Homo sapiens	Q9C0K0	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Crosslink	26949739
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	35271311
Intra	HDAC2	Q92769	MTA1	Homo sapiens	Q13330	Anti Bait CoIP	20651739
Intra	HDAC2	Q92769	BRMS1	Homo sapiens	Q9HCU9	Anti Bait CoIP	21258344
Intra	HDAC2	Q92769	BRMS1	Homo sapiens	Q9HCU9	Anti Tag CoIP	16919237
Intra	HDAC2	Q92769	BRMS1	Homo sapiens	Q9HCU9	Anti Tag CoIP	23752268
Intra	HDAC2	Q92769	SRA1	Homo sapiens	Q9HD15	Anti Bait CoIP	20398657
Intra	HDAC2	Q92769	DAXX	Homo sapiens	Q9UER7	CoIP	12140263
Intra	HDAC2	Q92769	MBD1	Homo sapiens	Q9UIS9	Pull Down	12711603
Cross	HDAC2	Q92769	K8	Human herpesvirus 8	Q2HR82	Anti Bait CoIP	22416134
Intra	HDAC2	Q92769	RFX5	Homo sapiens	P48382	Anti Bait CoIP	16464847
Intra	HDAC2	Q92769	RFX5	Homo sapiens	P48382	Anti Tag CoIP	16464847

Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80699	HDAC2 Antibody (YA742)	WB, ICC/IF	Human, Mouse, Rat, Monkey

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Primary Hyperoxaluria

Hyperoxaluria, Primary	Oxalosis
Hyperoxaluria	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10	Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures
Optic Atrophy 10	Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson-Gilford Disease
Hutchinson Gilford Progeria Syndrome	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Otopalatodigital Syndrome, Type I

Otopalatodigital Syndrome Type 1	Taybi Syndrome
OPD1	Opd Syndrome 1
Oto-Palato-Digital Syndrome Type 1	Opd I Syndrome
Oto-Palato-Digital Syndrome, Type I	Otopalatodigital Syndrome Type I
Opd Syndrome	Cranioorodigital Syndrome
Faciopalatoosseous Syndrome	Fpo
Opd Syndrome, Type 1	Otopalatodigital Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10221	Vorinostat	Inhibitor	99.95%	Yes
HY-10585	Valproic acid	Inhibitor	98.88%	Unkown
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-109015	Tucidinostat	Inhibitor	98.60%	Unkown
HY-10585A	Valproic acid sodium	Inhibitor	98.14%	Unkown
HY-12164	Mocetinostat	Inhibitor	99.68%	Yes
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes
HY-10585B	Valproic acid (sodium)(2:1)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12163	Entinostat	Inhibitor	99.82%	Phase 3
HY-50934	Tacedinaline	Inhibitor	99.32%	Phase 3
HY-10990	Abexinostat	Inhibitor	98.63%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.81%	Phase 2
HY-100748	Zabadinostat	Inhibitor	99.81%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.42%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1
HY-15994	Citarinostat	Inhibitor	99.30%	Phase 1
HY-124295	MPT0E028	Inhibitor	99.40%	Phase 1

Pre-clinical Phase

Bioactive Molecules (113)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-N0931	Santacruzamate A	Inhibitor	99.04%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-19327	ACY-738	Inhibitor	99.92%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-19618	BRD3308	Inhibitor	98.82%	Unkown
HY-100719	BRD-6929	Inhibitor	99.04%	Unkown
HY-104008	ACY-957	Inhibitor	99.66%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-111400	SR-4370	Inhibitor	99.95%	Unkown
HY-18976	UF010		99.84%	Unkown
HY-19328	ACY-775	Inhibitor	99.69%	Unkown
HY-100871	WT-161	Inhibitor	98.36%	Unkown
HY-18712	BG45	Inhibitor	99.96%	Unkown
HY-19348	Pimelic Diphenylamide 106	Inhibitor	98.54%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-116818	Crebinostat	Inhibitor	99.79%	Unkown
HY-10585R	Valproic acid (Standard)	Inhibitor	/	Unkown
HY-117709	BRD6688	Inhibitor	98.90%	Unkown
HY-100384	NKL 22	Inhibitor	97.27%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-124053	BRD2492	Inhibitor	99.18%	Unkown
HY-117583	cis-BG47	Inhibitor	98.02%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-146346	HD-TAC7	Inhibitor	98.75%	Unkown
HY-18700	BRD73954	Inhibitor	≥98.0%	Unkown
HY-102083	BRD4884	Inhibitor	≥99.0%	Unkown
HY-156422	KPZ560	Inhibitor	99.72%	Unkown
HY-131708A	FNDR-20123	Inhibitor	98.08%	Unkown
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	/	Unkown
HY-151261	HDAC6-IN-13	Inhibitor	98.08%	Unkown
HY-152174	HDAC-IN-52	Inhibitor	99.46%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-128582	PI3K/HDAC-IN-1	Inhibitor	/	Unkown
HY-151464	SHP2/HDAC-IN-1	Inhibitor	/	Unkown
HY-131708	FNDR-20123 free base	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-143497	HDAC1/2 and CDK2-IN-1	Inhibitor	/	Unkown
HY-161783	HDAC6-IN-45	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-147873	NMDAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-169938	LSD1/HDAC-IN-2	Inhibitor	/	Unkown
HY-162955	LSD1/HDAC-IN-1	Inhibitor	/	Unkown
HY-152146	HDAC-IN-50	Inhibitor	/	Unkown
HY-154855	HDAC-IN-56	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-145852	Top/HDAC-IN-2	Inhibitor	/	Unkown
HY-151248	HDAC2-IN-1	Inhibitor	/	Unkown
HY-133147	HDAC3/6-IN-2	Inhibitor	/	Unkown
HY-144297	HDAC1-IN-3	Inhibitor	/	Unkown
HY-149946	HDAC-IN-57	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-159171	sEH/HDAC6-IN-2	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-150577	HDAC-IN-45	Inhibitor	/	Unkown
HY-144654	HDAC/Top-IN-1	Inhibitor	/	Unkown
HY-144293	HDAC-IN-31	Inhibitor	/	Unkown
HY-161667	GSK-3β/HDAC-IN-1	Inhibitor	/	Unkown
HY-144395	HDAC6-IN-4	Inhibitor	/	Unkown
HY-149029	TH-6	Inhibitor	95.00%	Unkown
HY-163282	NB512	Inhibitor	/	Unkown
HY-151569	SAHA-OH	Inhibitor	/	Unkown
HY-157481	HDAC1-IN-6	Inhibitor	/	Unkown
HY-143324	A2AAR/HDAC-IN-1	Inhibitor	/	Unkown
HY-162769	HDAC3-IN-5	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-147840	HDAC-IN-41	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-162910	HDAC-IN-79	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-146392	HDAC-IN-39	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-162487	HDAC-IN-72	Inhibitor	/	Unkown
HY-143877	NN-390	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-169226	HDAC6-IN-51	Inhibitor	/	Unkown
HY-146276	CDK/HDAC-IN-2	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-152173	HDAC-IN-51	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-163834	HDAC6-IN-47	Inhibitor	/	Unkown
HY-144292	HDAC-IN-30	Inhibitor	/	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-161524	HDAC6-IN-43	Inhibitor	/	Unkown
HY-146160	PARP-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-162319	Tubulin/HDAC-IN-4	Inhibitor	/	Unkown
HY-115941	HDAC-IN-9	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-144332	PHD2/HDACs-IN-1	Inhibitor	/	Unkown
HY-117374	HDAC3-IN-1	Inhibitor	/	Unkown
HY-163207	sEH/HDAC6-IN-1	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-109015S	Tucidinostat-d4	Inhibitor	/	Unkown
HY-125645	M122	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown
HY-124337	BG48	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-19754	CRA-026440	Inhibitor	/	Unkown
HY-119316A	CM-545	Inhibitor	/	Unkown
HY-117583A	BG47	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HDAC2	RGD	RGD:619976
Canis familiaris	HDAC2	VGNC	VGNC:49101
Mus musculus	HDAC2	MGD	MGI:1097691
Bos taurus	HDAC2	VGNC	VGNC:50610
Felis catus	HDAC2	VGNC	VGNC:97454
Macaca mulatta	HDAC2	VGNC	VGNC:73358

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