KLB - klotho beta Gene

Homo sapiens

Also known as BKL

Gene ID: 152831 | Gene type: protein coding

About KLB

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,406,930-39,451,533 (from NCBI)

This gene has 1 transcript (splice variant), 202 orthologues and 4 paralogues. Biased expression in fat (RPKM 16.3), liver (RPKM 5.1) and 2 other tissues.

Summary

Enables Fibroblast Growth Factor binding activity and Fibroblast Growth Factor receptor binding activity. Predicted to be involved in Fibroblast Growth Factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by Fibroblast Growth Factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

KLB Products(1)

mRNA	Protein	Name
NM_175737.4	NP_783864.1	beta-klotho

KLB Protein Structure

Glyco_hydro_1

0
200
400
600
800
1044 a.a.

Protein Preferred Names

Protein Names

beta-klotho

b-Klotho

Recombinant KLB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77972	Klotho beta Protein, Human (HEK293, His)	Q86Z14 (M30-T983)	≥95%

Related Diseases

Diseases

Alias

Functional Diarrhea

Functional Diarrhoea

Outlet Dysfunction Constipation

Epilepsy, Idiopathic Generalized 4

EIG4	Epilepsy, Idiopathic Generalized, Susceptibility To 4
Idiopathic Generalized Epilepsy 4	Epilepsy, Idiopathic Generalized, Susceptibility To, 4
Epilepsy, Idiopathic Generalized Locus On Chromosome 10	Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10

Hypogonadotropic Hypogonadism 23 With Or Without Anosmia

Fertile Eunuch Syndrome	Pasqualini Syndrome
HH23	46,Xy Disorder Of Sex Development Due To Lhb Deficiency
46,Xy Disorder Of Sex Development Due To Luteinizing Hormone Subunit Beta Deficiency	46,Xy Dsd Due To Lhb Deficiency
46,Xy Dsd Due To Luteinizing Hormone Subunit Beta Deficiency	Leydig Cell Hypoplasia Due To Lhb Deficiency
Leydig Cell Hypoplasia Due To Luteinizing Hormone Subunit Beta Deficiency	Eunuchoidism With Spermatogenesis, Normal Fsh And Low Or Normal Interstitial Cell-Stimulating Hormone
Hypogonadism, Hypogonadotropic, Type 23, With/Without Anosmia

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis	Encephalitis, Tick-Borne
Central European Encephalitis	Far Eastern Tbe
Russian Spring-Summer Encephalitis	Taiga Encephalitis
West-Siberian Encephalitis	Western European Tick-Borne Encephalitis
Tbe	Encephalitis Tick-Borne
Encephalitis, Central European	Encephalitis, Far Eastern Russian

Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy	Gravidic Intrahepatic Cholestasis
Pregnancy-Related Cholestasis	Icp
Pregnancy Related Cholestasis	Cholestasis, Intrahepatic Of Pregnancy
Familial Intrahepatic Cholestasis Of Pregnancy	Familial Recurrent Intrahepatic Cholestasis Of Pregnancy
Ricp	Obstetric Cholestasis

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07325	KLB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KLB	VGNC	VGNC:73835
Felis catus	KLB	VGNC	VGNC:63126
Bos taurus	KLB	VGNC	VGNC:30622
Canis familiaris	KLB	VGNC	VGNC:42426
Mus musculus	KLB	MGD	MGI:1932466
Rattus norvegicus	KLB	RGD	RGD:1308227
Others	KLB	NCBI

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