DAB2IP - DAB2 interacting protein Gene

Homo sapiens

Also known as AIP1; AIP-1; AF9Q34; DIP1/2

Gene ID: 153090 | Gene type: protein coding

About DAB2IP

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:121,567,074-121,785,530 (from NCBI)

This gene has 11 transcripts (splice variants), 238 orthologues and 10 paralogues. Ubiquitous expression in colon (RPKM 8.5), testis (RPKM 8.5) and 24 other tissues.

Summary

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

DAB2IP Products(3)

mRNA	Protein	Name
NM_001395010.1	NP_001381939.1	disabled homolog 2-interacting protein isoform 3
NM_032552.4	NP_115941.2	disabled homolog 2-interacting protein isoform 1
NM_138709.2	NP_619723.1	disabled homolog 2-interacting protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	17389591	GOA
enables SH3 domain binding	IDA IDA: Inferred from direct assay	19033661	GOA
NOT enables Toll-like receptor 4 binding	IDA IDA: Inferred from direct assay	19948740	GOA
enables death receptor binding	IPI IPI: Inferred from physical interaction	15310755	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12813029	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	17389591	GOA
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	17389591	GOA
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	12813029	GOA
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	19033661	GOA
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	19903888	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	19948740	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	19948740	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12813029	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12813029	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	18281285	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20080667	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	20080667	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	19903888	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	19903888	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	19903888	GOA
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: Inferred from physical interaction	19033661	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	19948740	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19948740	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	12813029	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	19033661	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	19903888	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12813029	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	19033661	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15310755	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19033661	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	20154697	GOA
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	19948740	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15310755	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19033661	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17389591	GOA
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	12813029	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	19903888	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	17389591	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19903888	GOA
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	18281285	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15310755	GOA
involved in protein catabolic process	IDA IDA: Inferred from direct assay	17389591	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	19903888	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19948740	GOA
involved in tube formation	IMP IMP: Inferred from mutant phenotype	19033661	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of AIP1-IRE1 complex	IDA IDA: Inferred from direct assay	18281285	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15310755	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	19948740	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15310755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAB2IP Protein Structure

RasGAP

DUF3498

0
200
400
600
800
1000
1189 a.a.

Protein Preferred Names

Protein Names

disabled homolog 2-interacting protein

ASK-interacting protein 1

Related Diseases

Diseases

Alias

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Arteriosclerosis

Arteriosclerotic Vascular Disease

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Aortic Aneurysm, Familial Abdominal, 1

Abdominal Aortic Aneurysm	Aortic Aneurysm, Familial Abdominal 1
Aneurysm, Abdominal Aortic	AAA
Aortic Aneurysm, Abdominal	AAA1
Aortic Aneurysm, Familial Abdominal	Aortic Aneurysm Abdominal
Abdominal Aortic Aneurysms	Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture
Abdomen Aneurysm	Abdominal Aorta Aneurysm
Aneurysm Of Abdominal Aorta	Aortic Abdomen Aneurysm
Aaa - [Abdominal Aortic Aneurysm]	Abdominal Aneurysm
Abdominal Aorta Aneurysm Rupture	Abdominal Aorta Aneurysm Ruptured
Abdominal Aortic Aneurysm Which Has Ruptured	Ruptured Aaa
Abdomen Aorta Aneurysm Ruptured	Abdomen Aorta Rupture
Abdomen Aortic Aneurysm Rupture	Abdomen Aneurysm Rupture
Abdomen Aortic Aneurysm Ruptured	Abdomen Aortic Rupture
Abdominal Aorta Rupture	Abdominal Aortic Rupture
Rupture Abdomen Aorta Aneurysm	Rupture Abdominal Aortic Aneurysm
Ruptured Abdomen Aneurysm	Ruptured Abdomen Aorta
Ruptured Abdomen Aortic	Ruptured Abdominal Aneurysm
Ruptured Abdominal Aorta	Ruptured Abdominal Aortic
Ruptured Aorta Abdominalis Aneurysm	False Abdomen Aorta Aneurysm Ruptured
False Abdominal Aortic Aneurysm Ruptured	False Abdominal Aorta Aneurysm Ruptured
False Abdomen Aortic Aneurysm Ruptured

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03512	DAB2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DAB2IP	RGD	RGD:621686
Mus musculus	DAB2IP	MGD	MGI:1916851
Felis catus	DAB2IP	VGNC	VGNC:61330
Bos taurus	DAB2IP	VGNC	VGNC:27866
Canis familiaris	DAB2IP	VGNC	VGNC:39760
Macaca mulatta	DAB2IP	VGNC	VGNC:71642

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