2. Gene
  3. Hpd - 4-hydroxyphenylpyruvic acid dioxygenase Gene

Hpd - 4-hydroxyphenylpyruvic acid dioxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Fla; Flp; Laf; Hppd; 4HPPD

Gene ID: 15445 | Gene type: protein coding

About Hpd

Summary

Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to act upstream of or within L-phenylalanine catabolic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. Is expressed in alimentary system; liver; musculature; and respiratory system. Used to study tyrosinemia type III. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Orthologous to human HPD (4-hydroxyphenylpyruvate dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Hpd Products(1)

mRNA Protein Name
NM_008277.3 NP_032303.1 4-hydroxyphenylpyruvate dioxygenase
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
31537781 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

4-hydroxyphenylpyruvate dioxygenase

4-hydroxyphenylpyruvic acid oxidase

F liver antigen

F protein

HPPDase

f Alloantigen

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131183 PROTAC PD-1/PD-L1 degrader-1 Inhibitor 99.52% Unkown
HY-P2477 Human PD-L1 inhibitor IV Inhibitor 99.68% Unkown
HY-P2478A Human PD-L1 inhibitor V TFA Inhibitor / Unkown
HY-135767 Bicyclopyrone Inhibitor / Unkown
HY-P2474 Human PD-L1 inhibitor I 98.93% Unkown
HY-P2478 Human PD-L1 inhibitor V Inhibitor 99.04% Unkown
HY-130625 PD-1/PD-L1-IN 6 Inhibitor / Unkown
HY-155740 PD-1/PD-L1-IN-32 Inhibitor / Unkown
HY-168080 PD-1/PD-L1-IN-51 Inhibitor / Unkown
HY-RS06335 HPD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpd NCBI NCBI:3242
Canis familiaris Hpd NCBI NCBI:610778
Macaca fascicularis Hpd NCBI NCBI:102132519
Rattus norvegicus Hpd NCBI NCBI:29531
Macaca mulatta Hpd NCBI NCBI:700940