ADSS2 - adenylosuccinate synthase 2 Gene

Homo sapiens

Also known as ADEH; ADSS; ADSS 2

Gene ID: 159 | Gene type: protein coding

About ADSS2

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:244,408,494-244,452,060 (from NCBI)

This gene has 3 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 31.2), thyroid (RPKM 14.9) and 25 other tissues.

Summary

This gene encodes the Enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

ADSS2 Products(2)

mRNA	Protein	Name
NM_001126.5	NP_001117.2	adenylosuccinate synthetase isozyme 2 isoform 1
NM_001365073.2	NP_001352002.1	adenylosuccinate synthetase isozyme 2 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylosuccinate synthase activity	IDA IDA: Inferred from direct assay	2004783	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 'de novo' AMP biosynthetic process	IDA IDA: Inferred from direct assay	27590927	GOA
involved in AMP biosynthetic process	IDA IDA: Inferred from direct assay	2004783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADSS2 Protein Structure

Adenylsucc_synt

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

adenylosuccinate synthetase isozyme 2

AMPSase 2

ADSS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADSS2	P30520	ADSS1	Homo sapiens	Q8N142	Anti Tag CoIP	33961781
Intra	ADSS2	P30520	ADSS1	Homo sapiens	Q8N142	Anti Tag CoIP	28514442
Intra	ADSS2	P30520	SMYD1	Homo sapiens	Q8NB12	Anti Tag CoIP	23455924
Intra	ADSS2	P30520	SMYD1	Homo sapiens	Q8NB12	Y2H	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

ADSS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82266	AdSS 2 Antibody (YA2011)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Eczema Herpeticum

Herpes Simplex Dermatitis	Herpes Simplex Eyelid Dermatitis
Kaposi Varicelliform Eruption	Herpes Simplex Dermatitis Of Eyelid
Herpes Simplex Virus Dermatitis	Herpes Simplex Virus Eyelid Dermatitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00420	ADSS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ADSS2	VGNC	VGNC:69733
Mus musculus	ADSS2	MGD	MGI:87948
Canis familiaris	ADSS2	VGNC	VGNC:37679
Bos taurus	ADSS2	VGNC	VGNC:25700
Felis catus	ADSS2	VGNC	VGNC:59661
Rattus norvegicus	ADSS2	RGD	RGD:1310508

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