SMYD1 - SET and MYND domain containing 1 Gene

Homo sapiens

Also known as BOP; KMT3D; ZMYND18; ZMYND22

Gene ID: 150572 | Gene type: protein coding

About SMYD1

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,067,825-88,113,384 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 5 paralogues. Restricted expression toward heart (RPKM 63.9).

Summary

Predicted to enable histone-lysine N-methyltransferase activity. Involved in positive regulation of myoblast differentiation and positive regulation of myotube differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SMYD1 Products(2)

mRNA	Protein	Name
NM_001330364.2	NP_001317293.1	histone-lysine N-methyltransferase SMYD1 isoform 2
NM_198274.4	NP_938015.1	histone-lysine N-methyltransferase SMYD1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	19783823	GOA
involved in positive regulation of myotube differentiation	IDA IDA: Inferred from direct assay	19783823	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMYD1 Protein Structure

SET

zf-MYND

0
100
200
300
400
490 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase SMYD1

CD8 beta opposite

SMYD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMYD1	Q8NB12	HOMEZ	Homo sapiens	Q8IX15-3	Validated Y2H	25416956
Intra	SMYD1	Q8NB12	DVL1	Homo sapiens	Q86TH3	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	DVL1	Homo sapiens	Q86TH3	Y2H Array	32296183
Intra	SMYD1	Q8NB12	SNX11	Homo sapiens	Q9Y5W9	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	SNX11	Homo sapiens	Q9Y5W9	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	SNX11	Homo sapiens	Q9Y5W9	Y2H Array	32296183
Intra	SMYD1	Q8NB12	ADSS2	Homo sapiens	P30520	TAP	24981860
Intra	SMYD1	Q8NB12	ADSS2	Homo sapiens	P30520	Anti Tag CoIP	33961781
Intra	SMYD1	Q8NB12	ADSS2	Homo sapiens	P30520	Anti Tag CoIP	28514442
Intra	SMYD1	Q8NB12	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	SMYD1	Q8NB12	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	KIF16B	Homo sapiens	Q96L93-6	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	KIF16B	Homo sapiens	Q96L93-6	Y2H Array	32296183
Intra	SMYD1	Q8NB12	KIF16B	Homo sapiens	Q96L93-6	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	PATZ1	Homo sapiens	Q9HBE1-4	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	PATZ1	Homo sapiens	Q9HBE1-4	Y2H Array	32296183
Intra	SMYD1	Q8NB12	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	SMYD1	Q8NB12	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	SMYD1	Q8NB12	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	RSPH6A	Homo sapiens	Q9H0K4	Y2H Array	32296183
Intra	SMYD1	Q8NB12	RSPH6A	Homo sapiens	Q9H0K4	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	RSPH6A	Homo sapiens	Q9H0K4	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	CIMIP2A	Homo sapiens	Q6J272	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	CIMIP2A	Homo sapiens	Q6J272	Y2H Array	32296183
Intra	SMYD1	Q8NB12	MYH7B	Homo sapiens	A7E2Y1-2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	MYH7B	Homo sapiens	A7E2Y1-2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	FAM86C1P	Homo sapiens	Q9NVL1-2	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	FAM83A	Homo sapiens	Q86UY5	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	FAM83A	Homo sapiens	Q86UY5	Y2H Array	32296183
Intra	SMYD1	Q8NB12	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	SMYD1	Q8NB12	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SMYD1	Q8NB12	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	TBRG1	Homo sapiens	Q3YBR2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	TBRG1	Homo sapiens	Q3YBR2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	MYH7B	Homo sapiens	A7E2Y1	Y2H	23455924
Intra	SMYD1	Q8NB12	UTP14A	Homo sapiens	Q9BVJ6	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	UTP14A	Homo sapiens	Q9BVJ6	Y2H Array	32296183
Intra	SMYD1	Q8NB12	UTP14A	Homo sapiens	Q9BVJ6	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	NEFL	Homo sapiens	P07196	Y2H Array	32296183
Intra	SMYD1	Q8NB12	NEFL	Homo sapiens	P07196	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	ZBTB44	Homo sapiens	Q8NCP5	Validated Y2H	25416956
Intra	SMYD1	Q8NB12	ZBTB44	Homo sapiens	Q8NCP5	Y2H Prey Pooling	25416956
Intra	SMYD1	Q8NB12	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	BHLHE40	Homo sapiens	O14503	Y2H Array	32296183
Intra	SMYD1	Q8NB12	CFAP68	Homo sapiens	Q9H5F2	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	SMYD1	Q8NB12	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	ZBTB3	Homo sapiens	Q9H5J0	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	ZBTB3	Homo sapiens	Q9H5J0	Y2H Array	32296183
Intra	SMYD1	Q8NB12	ZBTB3	Homo sapiens	Q9H5J0	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	SMYD1	Q8NB12	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	SMYD1	Q8NB12	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	HDHD3	Homo sapiens	Q9BSH5	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	HDHD3	Homo sapiens	Q9BSH5	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	HDHD3	Homo sapiens	Q9BSH5	Y2H Array	32296183
Intra	SMYD1	Q8NB12	FAM204A	Homo sapiens	Q9H8W3	Validated Y2H	32296183
Intra	SMYD1	Q8NB12	FAM204A	Homo sapiens	Q9H8W3	Y2H Prey Pooling	32296183
Intra	SMYD1	Q8NB12	FAM204A	Homo sapiens	Q9H8W3	Y2H Array	32296183
Intra	SMYD1	Q8NB12	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	SMYD1	Q8NB12	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SMYD1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80895	SMYD1 Antibody (YA672)	WB	Rat

Related Diseases

Diseases

Alias

Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat

Epiphyseal Dysplasia, Multiple, 1

EDM1	Multiple Epiphyseal Dysplasia 1
Multiple Epiphyseal Dysplasia Type 1	Med1
Multiple Epiphyseal Dysplasia Comp-Related	Polyepiphyseal Dysplasia Type 1
Multiple Epiphyseal Dysplasia, Comp-Related	Epiphyseal Dysplasia Multiple 1
Epiphyseal Dysplasia, Multiple 1	Dysplasia, Epiphyseal, Multiple, Type 1

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13461	SMYD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SMYD1	VGNC	VGNC:46581
Bos taurus	SMYD1	VGNC	VGNC:35042
Macaca mulatta	SMYD1	VGNC	VGNC:77751
Rattus norvegicus	SMYD1	RGD	RGD:1305105
Felis catus	SMYD1	VGNC	VGNC:81223
Mus musculus	SMYD1	MGD	MGI:104790

Name
Email *

	Sorry, but the email address you supplied was invalid.