DACH1 - dachshund family transcription factor 1 Gene

Homo sapiens

Also known as DACH

Gene ID: 1602 | Gene type: protein coding

About DACH1

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:71,437,966-71,867,204 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 3.2), gall bladder (RPKM 2.4) and 21 other tissues.

Summary

This gene encodes a chromatin-associated protein that associates with Other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic Cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

DACH1 Products(4)

mRNA	Protein	Name
NM_001366712.1	NP_001353641.1	dachshund homolog 1 isoform d
NM_004392.7	NP_004383.4	dachshund homolog 1 isoform c
NM_080759.6	NP_542937.3	dachshund homolog 1 isoform a
NM_080760.6	NP_542938.3	dachshund homolog 1 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20956529	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20956529	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20956529	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14525983	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16980615	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21750150	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	20956529	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20956529	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	20956529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DACH1 Protein Structure

Ski_Sno

0
200
400
600
708 a.a.

Protein Preferred Names

Protein Names

dachshund homolog 1

dac homolog

DACH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DACH1	Q9UI36	NAGK	Homo sapiens	Q9UJ70	Y2H	21516116
Intra	DACH1	Q9UI36	NAGK	Homo sapiens	Q9UJ70	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colobomatous Microphthalmia

Anophthalmia-Microphthalmia Syndrome	Mac
Microphthalmia With Colobomatous Cyst	Microphthalmia-Anophthalmia-Coloboma Syndrome
Microphthalmia-Anophthalmia-Coloboma	Microphthalmia And Mental Deficiency

Granular Cell Carcinoma

Granular Cell Cancer

Granular Cell Adenocarcinoma

Supraglottis Neoplasm

Neoplasm Of Supraglottis

Supraglottic Tumor

Deafness, Autosomal Dominant 10

DFNA10	Autosomal Dominant Nonsyndromic Deafness 10
Autosomal Dominant Deafness 10	Deafness, Autosomal Dominant, 10
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 10	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 10
Deafness, Autosomal Dominant, Type 10

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Branchiootorenal Syndrome

Branchio-Oto-Renal Syndrome	Bor Syndrome
Branchiootorenal Dysplasia	Melnick-Fraser Syndrome
Branchiootorenal Spectrum Disorders	Branchio-Otorenal Dysplasia
Branchio Oto Renal Syndrome	Branchiootorenal/Branchiootic Syndrome
Bo Syndrome	Bor
Bos	Branchio-Otorenal Syndrome
Branchiootic Syndrome	Branchiootorenal Syndrome
Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03513	DACH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DACH1	MGD	MGI:1277991
Rattus norvegicus	DACH1	RGD	RGD:1592073
Bos taurus	DACH1	VGNC	VGNC:106704
Macaca mulatta	DACH1	VGNC	VGNC:71725

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