2. Gene
  3. AP2A2 - adaptor related protein complex 2 subunit alpha 2 Gene

AP2A2 - adaptor related protein complex 2 subunit alpha 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HIP9; HYPJ; ADTAB; HIP-9; CLAPA2

Gene ID: 161 | Gene type: protein coding

About AP2A2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:925,870-1,012,240 (from NCBI)

This gene has 36 transcripts (splice variants), 1 gene allele, 196 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 30.8), brain (RPKM 22.0) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]

AP2A2 Products(2)

mRNA Protein Name
NM_001242837.2 NP_001229766.1 AP-2 complex subunit alpha-2 isoform 1
NM_012305.4 NP_036437.1 AP-2 complex subunit alpha-2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15598649 GOA
Biological Process GO Annotation Evidence Reference Source
involved in clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
23676497 GOA
involved in clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
22262466 GOA
Cellular Component GO Annotation Evidence Reference Source
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
23676497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AP2A2 Protein Structure

Adaptin_N

Adaptin_N: Adaptin N terminal region (31 - 587)

Alpha_adaptinC2

Alpha_adaptinC2: Adaptin C-terminal domain (713 - 818)

Alpha_adaptin_C

Alpha_adaptin_C: Alpha adaptin AP2, C-terminal domain (826 - 934)

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  • 800
  • 939 a.a.
Protein Preferred Names Protein Names

AP-2 complex subunit alpha-2

100 kDa coated vesicle protein C

AP2A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
AP2A2 O94973 P0DTD1-PRO_0000449628 SARS-CoV-2 P0DTD1-PRO_0000449628
Y2H Array
36217030
Intra
AP2A2 O94973 AAGAB Homo sapiens Q6PD74
Y2H Prey Pooling
32296183
Intra
AP2A2 O94973 AAGAB Homo sapiens Q6PD74
Validated Y2H
32296183
Intra
AP2A2 O94973 AAGAB Homo sapiens Q6PD74
Y2H Array
32296183
Cross
AP2A2 O94973 Kcnj11 Mus musculus Q61743
Pull Down
16902404
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00785 AP2A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-159879 AAK1-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AP2A2 VGNC VGNC:69963
Mus musculus AP2A2 MGD MGI:101920
Rattus norvegicus AP2A2 RGD RGD:71015
Canis familiaris AP2A2 VGNC VGNC:37959
Bos taurus AP2A2 VGNC VGNC:25984
Felis catus AP2A2 VGNC VGNC:67725