2. Gene
  3. AP2A2 - adaptor related protein complex 2 subunit alpha 2 Gene

AP2A2 - adaptor related protein complex 2 subunit alpha 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HIP9; HYPJ; ADTAB; HIP-9; CLAPA2

Gene ID: 161 | Gene type: protein coding

About AP2A2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:925,870-1,012,240 (from NCBI)

This gene has 36 transcripts (splice variants), 1 gene allele, 196 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 30.8), brain (RPKM 22.0) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]

AP2A2 Products(2)

mRNA Protein Name
NM_001242837.2 NP_001229766.1 AP-2 complex subunit alpha-2 isoform 1
NM_012305.4 NP_036437.1 AP-2 complex subunit alpha-2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15598649 GOA
Biological Process GO Annotation Evidence Reference Source
involved in clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
23676497 GOA
involved in clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
22262466 GOA
Cellular Component GO Annotation Evidence Reference Source
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
23676497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AP2A2 Protein Structure

Adaptin_N

Adaptin_N: Adaptin N terminal region (31 - 587)

Alpha_adaptinC2

Alpha_adaptinC2: Adaptin C-terminal domain (713 - 818)

Alpha_adaptin_C

Alpha_adaptin_C: Alpha adaptin AP2, C-terminal domain (826 - 934)

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  • 939 a.a.
Protein Preferred Names Protein Names

AP-2 complex subunit alpha-2

100 kDa coated vesicle protein C

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00785 AP2A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AP2A2 VGNC VGNC:69963
Mus musculus AP2A2 MGD MGI:101920
Rattus norvegicus AP2A2 RGD RGD:71015
Canis familiaris AP2A2 VGNC VGNC:37959
Bos taurus AP2A2 VGNC VGNC:25984
Felis catus AP2A2 VGNC VGNC:67725