DAP - death associated protein Gene

Homo sapiens

Also known as DAP1

Gene ID: 1611 | Gene type: protein coding

About DAP

Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:10,679,230-10,761,234 (from NCBI)

This gene has 6 transcripts (splice variants), 167 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 62.5), urinary bladder (RPKM 56.2) and 25 other tissues.

Summary

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

DAP Products(2)

mRNA	Protein	Name
NM_001291963.2	NP_001278892.1	death-associated protein 1 isoform 1
NM_004394.3	NP_004385.1	death-associated protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables death domain binding	IPI IPI: Inferred from physical interaction	1087798	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	1087798	GOA
acts upstream of or within apoptotic process	IGI IGI: Inferred from genetic interaction	7828849	GOA
involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	1087798	GOA
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	20537536	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	1087798	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	1087798	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20537536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAP Protein Structure

DAP

0
102 a.a.

Protein Preferred Names

Protein Names

death-associated protein 1

DAP-1

DAP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82896	DAP1 Antibody (YA2641)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (61)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100714A	D-AP5	Antagonist	99.94%	Unkown
HY-P1070	Amylin, amide, human		98.02%	Unkown
HY-33046	N-Boc-dolaproine	Inhibitor	99.96%	Unkown
HY-P4931	Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2		99.87%	Unkown
HY-78931	Boc-Dap-NE		99.94%	Unkown
HY-W010922	Fmoc-Dap(Boc)-OH		99.98%	Unkown
HY-W010962	Fmoc-Dap(Alloc)-OH		99.59%	Unkown
HY-78932A	Dap-NE hydrochloride		99.98%	Unkown
HY-P1070A	Amylin, amide, human TFA		98.76%	Unkown
HY-W047799	Boc-Dap(Boc)-OH		≥95.0%	Unkown
HY-W048673	Fmoc-Phe(4-CONH2)-OH		99.35%	Unkown
HY-W008325	Boc-L-Dap-OH		≥98.0%	Unkown
HY-W046355	Fmoc-D-Dap(Boc)-OH		99.56%	Unkown
HY-164170	Photocaged DAP		98.13%	Unkown
HY-130961	Boc-Val-Dil-Dap-OH		98.52%	Unkown
HY-144022	16:0 DAP		≥98.0%	Unkown
HY-78931A	(R,S,S,R,S)-Boc-Dap-NE		/	Unkown
HY-P3120	Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2		96.30%	Unkown
HY-W014692	Boc-D-2,3-diaminopropionic acid		≥97.0%	Unkown
HY-151715	N3-D-Dap(Fmoc)-OH		99.87%	Unkown
HY-78931B	(S,S,S,S,R)-Boc-Dap-NE		/	Unkown
HY-78931C	(S,S,R,S,R)-Boc-Dap-NE		/	Unkown
HY-78931E	(R,S,R,S,R)-Boc-Dap-NE		/	Unkown
HY-78931F	(R,S,S,S,R)-Boc-Dap-NE		/	Unkown
HY-78931G	Boc-Dap-NE (GMP)		/	Unkown
HY-78932G	Dap-NE (hydrochloride) (GMP)		/	Unkown
HY-100714B	L-AP5	Antagonist	/	Unkown
HY-100781	D-AP4	Antagonist	/	Unkown
HY-118316	GSK223	Inhibitor	/	Unkown
HY-121634	DAP-81	Inhibitor	/	Unkown
HY-130956	Boc-NMe-Val-Val-Dil-Dap-OH		/	Unkown
HY-130975	Boc-Val-Dil-Dap-Phe-OMe		/	Unkown
HY-130976	N-Boc-Val-Dil-Dap-Doe		/	Unkown
HY-143700	18:0 DAP		/	Unkown
HY-144020	14:0 DAP		/	Unkown
HY-151640	Fmoc-DAP-N3		/	Unkown
HY-154981	Mal-L-Dap(Boc)-OSu		/	Unkown
HY-160795	Boc-NMeVal-Val-Dil-Dap		/	Unkown
HY-164787	N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine	Inhibitor	/	Unkown
HY-P1274	ShK-Dap22	Inhibitor	/	Unkown
HY-P3098	Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2		/	Unkown
HY-P3477	Mca-PLA-Nva-Dap(Dnp)-AR-NH2		/	Unkown
HY-P4905	Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2	Inhibitor	/	Unkown
HY-P5524	C12-iE-DAP	Agonist	/	Unkown
HY-RS03525	DAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03526	DAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W109214	Fmoc-L-Dap(Boc,Me)-OH		/	Unkown
HY-W337644	Fmoc-L-Homoarg(Et)2-OH hydrochloride		/	Unkown
HY-107719	D-AP7		/	Unkown
HY-151736	N3-L-Dap(Boc)-OH		/	Unkown
HY-151780	Fmoc-L-Dap(Pentynoyl)-OH		/	Unkown
HY-151781	Fmoc-L-Dap(Poc)-OH		/	Unkown
HY-151849	Z-L-Dap(N3)-OH		/	Unkown
HY-162819	Apoptosis inducer 26	Inducer	/	Unkown
HY-164867	Fmoc-L-Dap(NBSD)-OH		/	Unkown
HY-78932	Dap-NE		/	Unkown
HY-78932C	(2S,3R)-Dap-NE hydrochloride	Inhibitor	/	Unkown
HY-78932D	(2R,3R)-Dap-NE hydrochloride		/	Unkown
HY-P4931A	Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA		/	Unkown
HY-P5523	iE-DAP	Agonist	/	Unkown
HY-W250408	Fmoc-NMe-Val-Val-Dil-Dap-OH		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DAP	RGD	RGD:620641
Bos taurus	DAP	VGNC	VGNC:50122
Macaca mulatta	DAP	VGNC	VGNC:71730
Mus musculus	DAP	MGD	MGI:1918190
Others	DAP	NCBI

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