Cd74 - CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Gene

Mus musculus

Also known as Ii; CLIP; DHLAG; HLADG; Ia-GAMMA

Gene ID: 16149 | Gene type: protein coding

About Cd74

Summary

Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd74 Products(2)

mRNA	Protein	Name
NM_001042605.1	NP_001036070.1	H-2 class II histocompatibility antigen gamma chain isoform 1
NM_010545.3	NP_034675.1	H-2 class II histocompatibility antigen gamma chain isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class II protein binding	IPI IPI: Inferred from physical interaction	7985028	MGI
contributes to cytokine binding	IDA IDA: Inferred from direct assay	18056708	MGI
enables cytokine receptor activity	IMP IMP: Inferred from mutant phenotype	12782713	MGI
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	18003616	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7985028	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within antigen processing and presentation	IDA IDA: Inferred from direct assay	3864916	MGI
acts upstream of or within antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	9432982	MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: Inferred from mutant phenotype	7679955	MGI
acts upstream of or within chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	7985028	MGI
acts upstream of or within chaperone cofactor-dependent protein refolding	IMP IMP: Inferred from mutant phenotype	7679955	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	8098731	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	7679955	MGI
acts upstream of or within intracellular protein transport	IDA IDA: Inferred from direct assay	11754812	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in macrophage migration inhibitory factor signaling pathway	IDA IDA: Inferred from direct assay	19413900	MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17045821	MGI
acts upstream of or within negative regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17045821	MGI
involved in negative regulation of mature B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	18056708	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	12782713	MGI
acts upstream of or within positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production	IDA IDA: Inferred from direct assay	19413900	MGI
involved in positive regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12782713	MGI
involved in positive regulation of dendritic cell antigen processing and presentation	IDA IDA: Inferred from direct assay	18003616	MGI
involved in positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	19413900	MGI
involved in positive regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	19413900	MGI
involved in positive regulation of type 2 immune response	IMP IMP: Inferred from mutant phenotype	11823488	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	7679955	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	11483509	MGI
acts upstream of or within protein-containing complex assembly	IDA IDA: Inferred from direct assay	7985028	MGI
involved in response to type II interferon	IDA IDA: Inferred from direct assay	32855215	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11854359	MGI
part of MHC class II protein complex	IDA IDA: Inferred from direct assay	7985028	MGI
part of NOS2-CD74 complex	IDA IDA: Inferred from direct assay	18003616	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	11854359	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7679955	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12417635	MGI
located in late endosome	IDA IDA: Inferred from direct assay	11483509	MGI
located in lysosome	IDA IDA: Inferred from direct assay	11483509	MGI
part of macrophage migration inhibitory factor receptor complex	IDA IDA: Inferred from direct assay	12782713	MGI
located in multivesicular body	IDA IDA: Inferred from direct assay	11854359	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	8294875	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	8098731	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

H-2 class II histocompatibility antigen gamma chain

HLA-DR-GAMMA	Ia-associated invariant chain
MHC class II-associated invariant chain	class II-associated invariant chain peptide
dinucleotide microsatellite	histocompatibility: class II antigens, gamma chain of
ia antigen-associated invariant chain	i

Recombinant Cd74 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72710	CD74 Protein, Mouse (160a.a, HEK293, His)	P04441-2 (Q56-L215)	≥95%
HY-P78262	CD74 Protein, Mouse (224a.a, HEK293, His)	P04441-1 (Q56-L279)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99731	Milatuzumab	Inhibitor	99.39%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1826	CLIP (86-100)		98.49%	Unkown
HY-N2245	Schisandrone	Inhibitor	99.85%	Unkown
HY-N15169	BG-136	Activator	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990728	Bezetabart	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd74	NCBI	NCBI:972

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