2. Gene
  3. Cd74 - CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Gene

Cd74 - CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ii; CLIP; DHLAG; HLADG; Ia-GAMMA

Gene ID: 16149 | Gene type: protein coding

About Cd74

Summary

Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd74 Products(2)

mRNA Protein Name
NM_001042605.1 NP_001036070.1 H-2 class II histocompatibility antigen gamma chain isoform 1
NM_010545.3 NP_034675.1 H-2 class II histocompatibility antigen gamma chain isoform 2
Protein Preferred Names Protein Names

H-2 class II histocompatibility antigen gamma chain

HLA-DR-GAMMA

Ia-associated invariant chain

MHC class II-associated invariant chain

class II-associated invariant chain peptide

dinucleotide microsatellite

histocompatibility: class II antigens, gamma chain of

ia antigen-associated invariant chain

i

Recombinant Cd74 Proteins

Cat. No. Product Name Accession Purity
HY-P72710 CD74 Protein, Mouse (160a.a, HEK293, His) P04441-2 (Q56-L215) ≥95%
HY-P78262 CD74 Protein, Mouse (224a.a, HEK293, His) P04441-1 (Q56-L279) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99731 Milatuzumab Inhibitor 99.39% Phase 2

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd74 NCBI NCBI:972