2. Gene
  3. CD74 - CD74 molecule Gene

CD74 - CD74 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as II; p33; CLIP; DHLAG; HLADG; Ia-GAMMA

Gene ID: 972 | Gene type: protein coding

About CD74

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,401,639-150,412,910 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues and is associated with 57 phenotypes. Broad expression in spleen (RPKM 1835.3), lymph node (RPKM 1421.7) and 24 other tissues.

Summary

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

CD74 Products(5)

mRNA Protein Name
NM_001025158.3 NP_001020329.1 HLA class II histocompatibility antigen gamma chain isoform c
NM_001025159.3 NP_001020330.1 HLA class II histocompatibility antigen gamma chain isoform a
NM_001364083.3 NP_001351012.1 HLA class II histocompatibility antigen gamma chain isoform d
NM_001364084.3 NP_001351013.1 HLA class II histocompatibility antigen gamma chain isoform e
NM_004355.4 NP_004346.1 HLA class II histocompatibility antigen gamma chain isoform b

CD74 Protein Structure

MHC2-interact

MHC2-interact: CLIP, MHC2 interacting (17 - 129)

MHCassoc_trimer

MHCassoc_trimer: Class II MHC-associated invariant chain trimerisation domain (136 - 207)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (221 - 271)

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  • 296 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen gamma chain

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Recombinant CD74 Proteins

Cat. No. Product Name Accession Purity
HY-P72931 CD74 Protein, Human (HEK293, His) NP_004346.1 (Q73-M232) ≥95%

Related Diseases

Diseases Alias
Mucinous Lung Adenocarcinoma
Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma

Mucin-Secreting Adenocarcinoma

Mucin-Secreting Carcinoma

Mucous Carcinoma

Pseudomyxoma Peritonei With Unknown Primary Site

Adenocarcinoma, Mucinous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99731 Milatuzumab Inhibitor 99.39% Phase 2

Orthologs Information

Species Symbol Source ID
Canis familiaris CD74 VGNC VGNC:38972
Bos taurus CD74 VGNC VGNC:52227
Macaca mulatta CD74 VGNC VGNC:70779
Rattus norvegicus CD74 RGD RGD:2313
Felis catus CD74 VGNC VGNC:60638
Mus musculus CD74 MGD MGI:96534
Others CD74 NCBI