2. Gene
  3. Il13ra2 - interleukin 13 receptor, alpha 2 Gene

Il13ra2 - interleukin 13 receptor, alpha 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD213a2; IL-13R-alpha-2

Gene ID: 16165 | Gene type: protein coding

About Il13ra2

Summary

This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Il13ra2 Products(2)

mRNA Protein Name
NM_001306059.1 NP_001292988.1 interleukin-13 receptor subunit alpha-2 isoform 2 precursor
NM_008356.4 NP_032382.1 interleukin-13 receptor subunit alpha-2 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23972995 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
15944273 MGI
acts upstream of or within negative regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
15944273 MGI
acts upstream of or within negative regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
15944273 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-13 receptor subunit alpha-2

Il13ra2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Il13ra2 O88786 Il13 Mus musculus P20109
Anti Bait CoIP
23972995
Intra
Il13ra2 O88786 Chi3l1 Mus musculus Q61362
Anti Bait CoIP
23972995
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il13ra2 Proteins

Cat. No. Product Name Accession Purity
HY-P75830 IL-13R alpha 2 Protein, Mouse (HEK293, Fc) O88786-1 (L22-K334) ≥95%
HY-P75831 IL-13R alpha 2 Protein, Mouse (HEK293, His-Fc) O88786-1 (L22-K334) ≥95%
HY-P75832 IL-13R alpha 2 Protein, Mouse (HEK293, His) O88786-1/NP_032382.1 (L22-K334) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10292 NOTA-Pep-1L / Unkown
HY-RS06689 IL13RA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il13ra2 NCBI NCBI:3598
Rattus norvegicus Il13ra2 NCBI NCBI:171060