ZFPM1 - zinc finger protein, FOG family member 1 Gene

Homo sapiens

Also known as FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A

Gene ID: 161882 | Gene type: protein coding

About ZFPM1

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,451,769-88,537,031 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues and 1 paralogue. Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

ZFPM1 Products(1)

mRNA	Protein	Name
NM_153813.3	NP_722520.2	zinc finger protein ZFPM1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11675338	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12483298	GOA
enables transcription corepressor activity	IGI IGI: Inferred from genetic interaction	15920471	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	21646796	GOA
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15920471	GOA
involved in platelet formation	IGI IGI: Inferred from genetic interaction	11675338	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	21646796	GOA
involved in regulation of definitive erythrocyte differentiation	IDA IDA: Inferred from direct assay	15920471	GOA
involved in regulation of definitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17207461	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15920471	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	15920471	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFPM1 Protein Structure

zf-C2H2_6

zf-H2C2_2

zf-C2H2_6

0
200
400
600
800
1006 a.a.

Protein Preferred Names

Protein Names

zinc finger protein ZFPM1

FOG-1

ZFPM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZFPM1	Q8IX07	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	21988832
Intra	ZFPM1	Q8IX07	RBBP4	Homo sapiens	Q09028	Pull Down	21047798

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Thrombocytopenia 1

Xlt	THC1
Thrombocytopenia, X-Linked	Thrombocytopenia, X-Linked, Intermittent
X-Linked Thrombocytopenia	X-Linked Thrombocytopenia With Normal Platelets
Thc	Thrombocytopenia, X-Linked, 1
Thrombocytopenia X-Linked	Thrombocytopenia X-Linked 1

Congenital Dyserythropoietic Anemia

Congenital Dyshaematopoietic Anaemia	Dyserythropoietic Anemia, Congenital
Cda	Anemia, Dyserythropoietic, Congenital
Anemia Dyserythropoietic Congenital	Cda - [Congenital Dyserythropoietic Anaemia]
Dyserythropoietic Dyshaematopoietic Congenital Anaemia	Dyshaematopoietic Anaemia
Dyserythropoietic Anaemia

Thrombocytopenia With Beta-Thalassemia, X-Linked

XLTT	Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome	Gata1-Related X-Linked Cytopenia
X-Linked Thrombocytopenia With Beta-Thalassemia	Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Retinitis Pigmentosa 56

RP56	Maculopathy, Impg2-Related
MACLP-IMPG2	Retinitis Pigmentosa, Type 56

Cutaneous Porphyria

Porphyria, Erythropoietic

Erythropoietic Porphyria

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Myelofibrosis

Primary Myelofibrosis	Agnogenic Myeloid Metaplasia
Idiopathic Myelofibrosis	Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia	Osteomyelofibrosis
Megakaryocytic Myelosclerosis	Myelosclerosis
Chronic Idiopathic Myelofibrosis	Myelofibrosis, Idiopathic
Myelofibrosis With Myeloid Metaplasia, Somatic	Myelofibrosis, Somatic
Aleukemic Myelosis	Bone Marrow Fibrosis
MYELOF	MMM
Agnogenic Myeloid Metaplasia With Myelofibrosis	Ammm
Myelosclerosis With Myeloid Metaplasia	Myelofibrosis Nos

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis	Transient Myeloproliferative Syndrome
Transient Myeloproliferative Disease	Mst
Tam	Leukemia, Transient, Of Down Syndrome
Tmd	Leukemia, Transient
Transient Leukemia	Transient Leukemia Of Down Syndrome

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16048	ZFPM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZFPM1	VGNC	VGNC:53486
Mus musculus	ZFPM1	MGD	MGI:1095400
Bos taurus	ZFPM1	VGNC	VGNC:58429
Rattus norvegicus	ZFPM1	RGD	RGD:1582810
Macaca mulatta	ZFPM1	VGNC	VGNC:104765

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