2. Gene
  3. DCTD - dCMP deaminase Gene

DCTD - dCMP deaminase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 1635 | Gene type: protein coding

About DCTD

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:182,890,091-182,917,611 (from NCBI)

This gene has 17 transcripts (splice variants), 245 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 37.0), adrenal (RPKM 19.8) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for Thymidylate Synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DCTD Products(9)

mRNA Protein Name
NM_001012732.2 NP_001012750.1 deoxycytidylate deaminase isoform a
NM_001351743.2 NP_001338672.1 deoxycytidylate deaminase isoform b
NM_001351744.2 NP_001338673.1 deoxycytidylate deaminase isoform b
NM_001351745.2 NP_001338674.1 deoxycytidylate deaminase isoform b
NM_001351747.2 NP_001338676.1 deoxycytidylate deaminase isoform b
NM_001351748.2 NP_001338677.1 deoxycytidylate deaminase isoform b
NM_001351750.2 NP_001338679.1 deoxycytidylate deaminase isoform b
NM_001351753.2 NP_001338682.1 deoxycytidylate deaminase isoform b
NM_001921.3 NP_001912.2 deoxycytidylate deaminase isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity IDA
IDA: Inferred from direct assay
33833118 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in nucleoside salvage IMP
IMP: Inferred from mutant phenotype
33833118 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCTD Protein Structure

dCMP_cyt_deam_1

dCMP_cyt_deam_1: Cytidine and deoxycytidylate deaminase zinc-binding region (14 - 128)

  • 0
  • 100
  • 178 a.a.
Protein Preferred Names Protein Names

deoxycytidylate deaminase

Related Diseases

Diseases Alias
Granulomatosis With Polyangiitis

GPA

Wegener Granulomatosis

Wegener Granulomatosis, Formerly

Midline Granulomatosis

Wg, Formerly

Necrotizing Respiratory Granulomatosis

Wg

Wegeners Granulomatosis

Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03592 DCTD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DCTD VGNC VGNC:71750
Canis familiaris DCTD VGNC VGNC:39815
Bos taurus DCTD VGNC VGNC:27927
Mus musculus DCTD MGD MGI:2444529
Felis catus DCTD VGNC VGNC:107325
Rattus norvegicus DCTD RGD RGD:1359671