2. Gene
  3. KANK4 - KN motif and ankyrin repeat domains 4 Gene

KANK4 - KN motif and ankyrin repeat domains 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ANKRD38; dJ1078M7.1

Gene ID: 163782 | Gene type: protein coding

About KANK4

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,236,165-62,319,434 (from NCBI)

This gene has 4 transcripts (splice variants), 296 orthologues and 3 paralogues. Biased expression in fat (RPKM 7.4), placenta (RPKM 5.9) and 10 other tissues.

Summary

Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

KANK4 Products(2)

mRNA Protein Name
NM_001320269.2 NP_001307198.1 KN motif and ankyrin repeat domain-containing protein 4 isoform 2
NM_181712.5 NP_859063.3 KN motif and ankyrin repeat domain-containing protein 4 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25961457 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KANK4 Protein Structure

KN_motif

KN_motif: KN motif (24 - 62)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (815 - 864)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (870 - 951)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 995 a.a.
Protein Preferred Names Protein Names

KN motif and ankyrin repeat domain-containing protein 4

ankyrin repeat domain 38

KANK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KANK4 Q5T7N3 CUL5 Homo sapiens Q93034
Validated Y2H
32296183
Intra
KANK4 Q5T7N3 MYLIP Homo sapiens Q8WY64
Validated Y2H
32296183
Intra
KANK4 Q5T7N3 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea

Chandler Syndrome

CHED

Chandler'S Syndrome

Endothelial Corneal Dystrophy

Ched2

Maumenee Corneal Dystrophy

Corneal Dystrophy, Congenital Hereditary Endothelial

Dystrophy Of Corneal Endothelium

Corneal Endothelial Dystrophy 2

Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly

Ched2, Formerly

Corneal Endothelial Dystrophy, Autosomal Recessive

Endothelial Dystrophy

Posterior Membrane Corneal Dystrophy

Corneal Endothelial Dystrophy Type 2

Congenital Hereditary Endothelial Dystrophy Of The Cornea

Congenital Hereditary Endothelial Dystrophy Type Ii

Autosomal Recessive Ched

Autosomal Recessive Congenital Hereditary Endothelial Dystrophy

Chedii

Congenital Hereditary Endothelial Dystrophy Type 2

Infantile Hereditary Endothelial Dystrophy

Congenital Hereditary Endothelial Corneal Dystrophy

Corneal Endothelial Dystrophy 2, Autosomal Recessive

Iridocorneal Endothelial Syndrome

Dystrophy, Corneal, Endothelial

Corneal Endothelial Dystrophy 1, Autosomal Dominant
Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome

CDPD

Harboyan Syndrome

Cdpd1

Corneal Dystrophy And Sensorineural Deafness

Corneal Endothelial Dystrophy And Perceptive Deafness

Corneal Dystrophy With Progressive Deafness

Congenital Corneal Dystrophy, Progressive Sensorineural Deafness

Corneal Dystrophy With Progressive Hearing Loss

Corneal Dystrophy-Perceptive Hearing Loss Syndrome

Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Hypertensive Encephalopathy

Encephalopathy, Hypertensive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07066 KANK4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KANK4 VGNC VGNC:55243
Canis familiaris KANK4 VGNC VGNC:42203
Mus musculus KANK4 MGD MGI:3043381
Rattus norvegicus KANK4 RGD RGD:1307635
Felis catus KANK4 VGNC VGNC:63017
Macaca mulatta KANK4 VGNC VGNC:73916