KANK4 - KN motif and ankyrin repeat domains 4 Gene

Homo sapiens

Also known as ANKRD38; dJ1078M7.1

Gene ID: 163782 | Gene type: protein coding

About KANK4

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,236,165-62,319,434 (from NCBI)

This gene has 4 transcripts (splice variants), 296 orthologues and 3 paralogues. Biased expression in fat (RPKM 7.4), placenta (RPKM 5.9) and 10 other tissues.

Summary

Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

KANK4 Products(2)

mRNA	Protein	Name
NM_001320269.2	NP_001307198.1	KN motif and ankyrin repeat domain-containing protein 4 isoform 2
NM_181712.5	NP_859063.3	KN motif and ankyrin repeat domain-containing protein 4 isoform 1

KANK4 Protein Structure

KN_motif

Ank_2

0
200
400
600
800
995 a.a.

Protein Preferred Names

Protein Names

KN motif and ankyrin repeat domain-containing protein 4

ankyrin repeat domain 38

Related Diseases

Diseases

Alias

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea	Chandler Syndrome
CHED	Chandler'S Syndrome
Endothelial Corneal Dystrophy	Ched2
Maumenee Corneal Dystrophy	Corneal Dystrophy, Congenital Hereditary Endothelial
Dystrophy Of Corneal Endothelium	Corneal Endothelial Dystrophy 2
Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly	Ched2, Formerly
Corneal Endothelial Dystrophy, Autosomal Recessive	Endothelial Dystrophy
Posterior Membrane Corneal Dystrophy	Corneal Endothelial Dystrophy Type 2
Congenital Hereditary Endothelial Dystrophy Of The Cornea	Congenital Hereditary Endothelial Dystrophy Type Ii
Autosomal Recessive Ched	Autosomal Recessive Congenital Hereditary Endothelial Dystrophy
Chedii	Congenital Hereditary Endothelial Dystrophy Type 2
Infantile Hereditary Endothelial Dystrophy	Congenital Hereditary Endothelial Corneal Dystrophy
Corneal Endothelial Dystrophy 2, Autosomal Recessive	Iridocorneal Endothelial Syndrome
Dystrophy, Corneal, Endothelial	Corneal Endothelial Dystrophy 1, Autosomal Dominant

Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome	CDPD
Harboyan Syndrome	Cdpd1
Corneal Dystrophy And Sensorineural Deafness	Corneal Endothelial Dystrophy And Perceptive Deafness
Corneal Dystrophy With Progressive Deafness	Congenital Corneal Dystrophy, Progressive Sensorineural Deafness
Corneal Dystrophy With Progressive Hearing Loss	Corneal Dystrophy-Perceptive Hearing Loss Syndrome
Dystrophy, Corneal, Endothelial, And Perceptive Deafness

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Hypertensive Encephalopathy

Encephalopathy, Hypertensive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07066	KANK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KANK4	VGNC	VGNC:55243
Canis familiaris	KANK4	VGNC	VGNC:42203
Mus musculus	KANK4	MGD	MGI:3043381
Rattus norvegicus	KANK4	RGD	RGD:1307635
Felis catus	KANK4	VGNC	VGNC:63017
Macaca mulatta	KANK4	VGNC	VGNC:73916

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