MYLIP - myosin regulatory light chain interacting protein Gene

Homo sapiens

Also known as MIR; IDOL

Gene ID: 29116 | Gene type: protein coding

About MYLIP

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:16,129,086-16,163,887 (from NCBI)

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 42.5), bone marrow (RPKM 32.5) and 23 other tissues.

Summary

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with Myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]

MYLIP Products(1)

mRNA	Protein	Name
NM_013262.4	NP_037394.2	E3 ubiquitin-protein ligase MYLIP

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	10593918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12826659	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21685362	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14550572	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10593918	GOA
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	10593918	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14550572	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYLIP Protein Structure

FERM_N

FERM_M

zf-C3HC4_3

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MYLIP

E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor

MYLIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MYLIP	Q8WY64	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	MYLIP	Q8WY64	NR1D2	Homo sapiens	Q6NSM0	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	NR1D2	Homo sapiens	Q6NSM0	Y2H Array	32296183
Intra	MYLIP	Q8WY64	CNPY2	Homo sapiens	Q9Y2B0	Pull Down	12826659
Intra	MYLIP	Q8WY64	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	MYLIP	Q8WY64	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	MYLIP	Q8WY64	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	MYLIP	Q8WY64	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	MYLIP	Q8WY64	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	MYLIP	Q8WY64	PAX9	Homo sapiens	P55771	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	PAX9	Homo sapiens	P55771	Y2H Array	32296183
Intra	MYLIP	Q8WY64	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	MYLIP	Q8WY64	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	MYLIP	Q8WY64	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	NHLRC4	Homo sapiens	P0CG21	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	NHLRC4	Homo sapiens	P0CG21	Y2H Array	32296183
Intra	MYLIP	Q8WY64	FAM217B	Homo sapiens	Q9NTX9	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	FAM217B	Homo sapiens	Q9NTX9	Y2H Array	32296183
Intra	MYLIP	Q8WY64	FAM217B	Homo sapiens	Q9NTX9	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	MYLIP	Q8WY64	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	MYLIP	Q8WY64	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	MYLIP	Q8WY64	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	MYLIP	Q8WY64	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	MYLIP	Q8WY64	LNX2	Homo sapiens	Q8N448	Y2H	21516116
Intra	MYLIP	Q8WY64	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	MYLIP	Q8WY64	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	MYLIP	Q8WY64	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	MYLIP	Q8WY64	ZBTB18	Homo sapiens	Q99592	Y2H Array	32296183
Intra	MYLIP	Q8WY64	ZBTB18	Homo sapiens	Q99592	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	ZBTB18	Homo sapiens	Q99592	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	RASSF5	Homo sapiens	Q8WWW0	Validated Y2H	25416956
Intra	MYLIP	Q8WY64	RASSF5	Homo sapiens	Q8WWW0	Y2H Prey Pooling	25416956
Intra	MYLIP	Q8WY64	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	MYLIP	Q8WY64	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	MYLIP	Q8WY64	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	MYLIP	Q8WY64	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	MYLIP	Q8WY64	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	MYLIP	Q8WY64	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	MYLIP	Q8WY64	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MYLIP	Q8WY64	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MYLIP	Q8WY64	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MYLIP	Q8WY64	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
Intra	MYLIP	Q8WY64	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
Intra	MYLIP	Q8WY64	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
Intra	MYLIP	Q8WY64	ZBTB16	Homo sapiens	Q05516	Y2H Array	32296183
Intra	MYLIP	Q8WY64	ZBTB16	Homo sapiens	Q05516	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	INO80B	Homo sapiens	Q9C086	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	INO80B	Homo sapiens	Q9C086	Y2H Array	32296183
Intra	MYLIP	Q8WY64	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	MYLIP	Q8WY64	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
Intra	MYLIP	Q8WY64	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	MYLIP	Q8WY64	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08922	MYLIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYLIP	VGNC	VGNC:75000
Mus musculus	MYLIP	MGD	MGI:2388271
Bos taurus	MYLIP	VGNC	VGNC:31805
Felis catus	MYLIP	VGNC	VGNC:63680
Rattus norvegicus	MYLIP	RGD	RGD:1305761
Canis familiaris	MYLIP	VGNC	VGNC:43548

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