MYLIP - myosin regulatory light chain interacting protein Gene

Homo sapiens

Also known as MIR; IDOL

Gene ID: 29116 | Gene type: protein coding

About MYLIP

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:16,129,086-16,163,887 (from NCBI)

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 42.5), bone marrow (RPKM 32.5) and 23 other tissues.

Summary

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory LIGHT chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with Myosin regulatory LIGHT chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]

MYLIP Products(1)

mRNA	Protein	Name
NM_013262.4	NP_037394.2	E3 ubiquitin-protein ligase MYLIP

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	10593918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12826659	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21685362	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	14550572	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	10593918	GOA
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	10593918	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	14550572	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYLIP Protein Structure

FERM_N

FERM_M

zf-C3HC4_3

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MYLIP

E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor

Related Diseases

Diseases

Alias

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08922	MYLIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYLIP	VGNC	VGNC:75000
Mus musculus	MYLIP	MGD	MGI:2388271
Bos taurus	MYLIP	VGNC	VGNC:31805
Felis catus	MYLIP	VGNC	VGNC:63680
Rattus norvegicus	MYLIP	RGD	RGD:1305761
Canis familiaris	MYLIP	VGNC	VGNC:43548

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